Anand Vaidya
@anandvaidya17.bsky.social
Adrenal physiology and medicine vaidya.bwh.harvard.edu
Low renin HTN and aldosterone-directed therapy www.ejinme.com/article/S095...
Low-renin hypertension in incidental adrenal adenomas and response to aldosterone-targeted therapy: a prospective study
Incidental adrenal adenomas are common, yet renin status is infrequently assessed in hypertensive patients. Emerging evidence supports a spectrum of renin-independent aldosterone excess associated wit...
ejinme.com
Primary Aldosteronism www.nature.com/articles/s41...
Primary aldosteronism - Nature Reviews Disease Primers
In this Primer, Vaidya and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with primary aldosteronism, an important cause of hypertension res...
nature.com
Re-Defining Primary Aldosteronism authors.elsevier.com/a/1mqFw2d9GI... @jaccjournals.bsky.social #JACC
"Over 80% of participants with obesity-related hypertension exhibited reproducible pathologic phenotypes of aldosteronism and/or hypercortisolism" www.jacc.org/doi/10.1016/...
Unmasking Hormonal Mechanisms of Hypertension in Obesity:
jacc.org
The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome 🔗 academic.oup.com/ajh/article/... 🔒
🧠 Dr. Vaidya’s @anandvaidya17.bsky.social practical approach to primary aldo, distilled into one clean, clinic-ready infographic: This is high-yield, no-fluff, practice-changing stuff.
www.youtube.com/watch?v=mqpl...
#515 Primary Aldosteronism, A Deep Dive: Easy on the Salt!
YouTube video by The Curbsiders Internal Medicine Podcast
youtube.com
@thecurbsiders.bsky.social · 7mo agoNew! 🎙️🩺🎧 #515 Primary Aldosteronism, A Deep Dive: Easy on the Salt! 🧂⬇️ Hypertension is everywhere and primary aldosteronism is a common (and often missed 👀) cause. Join us with @anandvaidya17.bsky.social of Brigham and Women’s Hospital
#ThrowbackThursday Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism academic.oup.com/ajh/article/... #EditorsChoice from 2022 #OpenAccess #Free
Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism
AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (
academic.oup.com
#WeekendReads from the Advance Articles section Time to retire Aldosterone Suppression Testing? academic.oup.com/ajh/advance-...
Is It Time to Retire Aldosterone Suppression Testing?
Abstract. Primary aldosteronism (PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving nonsuppressibility of aldost
academic.oup.com
Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process academic.oup.com/ejendo/artic...
Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism
AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald
academic.oup.com
To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension. www.jacc.org/doi/10.1016/...
Adrenal insufficiency is a syndrome of cortisol deficiency. This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis. ja.ma/3HKk9Jr
Don't miss the preprint from: @alice.soragnilab.com @michaelyehmd.bsky.social @anandvaidya17.bsky.social @nicolebechmann.bsky.social 🏥 @uthealthsa.bsky.social @dgsomucla.bsky.social @harvardmed.bsky.social @mdanderson.bsky.social @tudresden.bsky.social www.biorxiv.org/content/10.1...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
biorxiv.org
🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10.... Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org
NEJM.org@nejm.org · last yr.A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL
A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL
#ENDO2026 Welcomes Your Ideas | Our annual meeting will take place in Chicago, IL, June 13–16, and I’m inviting YOU to shape the program💡Submit your symposium proposal or session suggestion by Tuesday, September 2: bit.ly/4flCMjl #endocrinology @TheEndoSociety
ENDO 2026 Session Submissions
ENDO wouldn’t be possible without the insight and expertise of the Endocrine community. Your ideas are essential to building a dynamic, forward-thinking program that reflects the full breadth of our f...
bit.ly
1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...
#ThrowbackThursday Variability of Aldosterone concentration while performing AVS academic.oup.com/ajh/article/... #Free #EditorsCHoice
Subclinical Primary Aldosteronism and MACE www.ahajournals.org/doi/10.1161/...
Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study | Circulation
BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evid...
ahajournals.org
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic academic.oup.com/jcem/advance...
The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome academic.oup.com/ajh/advance-...
A pragmatic approach to evaluate for ADRENAL INSUFFICIENCY Thanks to @irinabancos.bsky.social and Jay Findling for lending their expertise!
JAMA@jama.com · last yr.Adrenal insufficiency is a syndrome of cortisol deficiency. This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis. https://ja.ma/43Zy2ui
Beautiful study. Stop the madness. Low-renin hypertension is by far and away some manifestation of primary aldosteronism pathophysiology. Even if you get caught up in names and definitions and can't accept this, it responds beautifully to MR antagonist therapy, so just do the right thing.
Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · last yr.In the @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management) #NephSky #EndoSky
In the @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management) #NephSky #EndoSky
Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0
Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...
acpjournals.org
Work smarter, not harder! A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism. Either way, aldosterone-directed therapy is very likely to provide major clinical benefits www.ahajournals.org/eprint/TUS6C...
Do patients want to be screened for primary aldosteronism: YES How much PA can be identified with a direct-to-patient approach: A LOT Can this approach be implemented nationwide: YES @JeniferBrown www.ahajournals.org/doi/10.1161/...
Subclinical primary aldosteronism + Natriuretic peptide deficiency => HYPERTENSION academic.oup.com/jcem/advance...
Interesting study looking at a direct-to-patient approach to implement primary aldosteronism screening. www.ahajournals.org/doi/10.1161/... (paywall) @jenifermbr.bsky.social @anandvaidya17.bsky.social #medsky #nephsky
Nationwide, Pragmatic, Direct-to-Patient Primary Aldosteronism Testing Program | Hypertension
BACKGROUND: Primary aldosteronism, an endocrinopathy present in ≥10% to 25% of patients with hypertension, confers excess cardiovascular risk that can be mitigated with aldosterone-directed therapy. H...
ahajournals.org