Just had the absolute pleasure of delivering a seminar / talk at the University of Birmingham about our drug discovery work - highlighting inhibitors of BLM as a therapeutic target in cancer.

Very pleased to have contributed to this paper, from Ochs/Blackford and colleagues, just published in Cell [!]

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · 2mo ago

[NEW PAPERs] Parallel studies from Ochs/Blackford + collaborators, including Antony Oliver from the GDSC [in Cell] - and Durocher + collaborators [in Mol. Cell] describing the role of DDIAS in binding and protecting single-stranded DNA during mitosis. doi.org/10.1016/j.ce..., doi.org/10.1016/j.mo...

Rather early start! Brighton > Sheffield for #SMBio 2026. Looking forward to hearing new and exciting ways to use single molecule data.

Very pleased to have been part of the team! Early access to article accepted for publication in Nature Communications. www.nature.com/articles/s41...

Heading to Cambridge for the annual Genome Stability Network meeting. Glad I’m on a train, as it’s grim outside!

Enjoying a little rest and recuperation in Rejkyavik, Iceland.

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · last yr.

#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF

A bit like buses... Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · last yr.

#NEW_PAPER The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

Many congratulations to Dr. Will Foster on succesfully defending his PhD thesis on Greatwall Kinase (GWL); co-supervissed by Tony Oliver and Helfrid Hochegger.

Snowy campus #nofilter

Well, I’ve joined BlueSky… (at long last) and look forward to posting some stuff on here soonest. Meanwhile @gdsc-sussex.bsky.social have also made the transition!