Office Hours: Episode 15

Explore how Dr. Craig Goergen leverages advanced biomedical imaging to bridge research and clinical applications, enhancing understanding of diseases and promoting interdisciplinary collaboration.

bmes.org

Loss of Chromosome Y and Risk of Abdominal Aortic Aneurysm

This cohort study evaluates the association between loss of chromosome Y and the incidence of aortic aneurysm based on anatomic location.

jamanetwork.com

From mummies to internal mammaries: A historical perspective on the development of cardiovascular bypass surgery

AbstractObjectives. To explore the historical development of contemporary surgical revascularization techniques.Methods. This narrative review synthesizes historical medical literature, surgical case ...

journals.bioscientifica.com

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune-evasion genes US2 and Serpin b9 into donor valve cells and...

advanced.onlinelibrary.wiley.com

Remnant virus proteins sustain vascular inflammation post coronavirus infection in mice and humans.

SARS-CoV-2 coronavirus infections are associated with long term vascular dysfunction, yet the drivers remain unclear. We hypothesized that remnant Betacoronavirus antigens remain in circulation and or...

portlandpress.com

Frontiers | Bioprosthetic heart valve degeneration: new insights into structural remodeling and calcification

Bioprosthetic heart valves (BHVs) are widely used to treat aortic valve disease, and their demand is rising. However, BHV lifespan remains limited by degener...

frontiersin.org

Frontiers | The PEDIAVALVE project – tissue-engineered pulmonary valves for paediatric valvular replacement

Current paediatric options for pulmonary heart valve (PHV) substitutes are imperfect, requiring numerous reinterventions until maturity. Substitutes with a d...

frontiersin.org

Non-invading cells that coordinate with tip cells during angiogenic sprout initiation exhibit a molecular signature driven by YAP and TAZ | American Journal of Physiology-Cell Physiology | American Ph...

Angiogenesis requires endothelial cell (EC) plasticity and differentiation into either invasive, migratory tip cells or proliferative stalk cells. Using a transcriptional analysis that distinguished t...

journals.physiology.org

Healthy bone marrow transplantation into hypertriglyceridemic rats improves cardiac reparative fibrosis post-myocardial infarction

AbstractAims. Acute myocardial infarction (AMI) triggers an immune response characterized by a dynamic interplay between the bone marrow (BM) and the ische

academic.oup.com

Cardiovascular Disease and Androgens: Clinical Trends, Potential Mechanisms, and Considerations for Engineering Solutions - Cardiovascular Engineering and Technology

This review summarizes the current understanding of androgen physiology, relationships between androgens and cardiovascular (CV) diseases, and novel engineering approaches to study the effect of andro...

link.springer.com

Patient-Specific Aortic Growth Prediction in Type B Aortic Dissection Using Finite-Element Simulation Based on the Unified Fiber Distribution (UFD) Model - Annals of Biomedical Engineering

Purpose Type B aortic dissection (TBAD) managed with optimal medical therapy (OMT) carries a 40–50% risk of progressive aneurysmal degeneration. Predicting which patients will experience significant a...

link.springer.com

Frontiers | Editorial: Future of heart valve surgery: enhancing outcomes with innovative technologies

Valvular heart disease is becoming more common as populations age, and the way we treat it has changed more in the past twenty years than in the fifty before...

frontiersin.org

sciencedirect.com

Optimizing predictive performance without sacrificing explainability: Comparing logistic regression and ensemble decision trees for abdominal aortic aneurysm repair outcomes

An abdominal aortic aneurysm (AAA) is an irreversible dilation of the terminal aorta, posing significant rupture risks. Current guidelines for surgical intervention rely on aneurysm diameter threshold...

jvsvi.org

sciencedirect.com

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy | Function | American Physiological Society

Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we descr...

journals.physiology.org

sciencedirect.com

Transcatheter aortic valve canting creates cusp-specific thrombogenic microenvironments through altered sinus hemodynamics

Transcatheter aortic valve replacement has transformed the management of aortic stenosis; however, leaflet thrombosis and hypoattenuated leaflet thickening remain major clinical concerns. Flow disturb...

jtcvsstructural.org

Thoracic aortic disease: prognostic role of gene variants and polygenic risk scores

AbstractBackground and Aims. Thoracic aortic aneurysm and dissection (TAAD) can have catastrophic health consequences. Eleven genes have strong or definiti

academic.oup.com

Mechanisms underlying rheumatic heart disease immune-mediated pathogenesis: T-cell responses, cytokine networks, and immune dysregulation as drivers of valvular injury

Acute rheumatic fever is an immune-mediated sequela of Streptococcus pyogenes (group A Streptococcus) infection, presenting with fever, arthritis, chorea, rash, and, crucially, carditis. Without effec...

thelancet.com

Sex-specific associations of the plasma-proteome with incident coronary artery disease

AbstractAims. The etiology of coronary artery Disease (CAD) appears different for men and women, yet insights into underlying sex-specific biological mecha

academic.oup.com

Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology

AbstractAims. Mitral regurgitation (MR) pathophysiology involves increased serotonin (5-HT) receptor (HTR) expression and signaling, together with reduced

academic.oup.com

High Embolic Risk with Orbital Atherectomy for Calcified Peripheral Artery Disease - Annals of Biomedical Engineering

Purpose Orbital atherectomy (OA) is used to treat heavily calcified peripheral arterial lesions, aiming to improve vessel compliance and reduce the need for high-pressure angioplasty and stenting. How...

link.springer.com

Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve Model - Cardiovascular Engineering and Technology

Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correla...

link.springer.com

jtcvsstructural.org

mdpi.com

Lipoprotein(a) carries triglyceride species associated with incident cardiovascular disease

Lipoprotein(a) [Lp(a)] is described as a low-density lipoprotein-like particle, but recent work suggests heterogeneity, including triglyceride (TG)-rich features. We investigated whether native Lp(a) ...

atherosclerosis-journal.com

Decoding Plaque Instability Through Plasma Proteomics Profiling?:

Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

jacc.org