Transplantation of Saccharomyces cerevisiae Rmd9p peptide into mammalian mitochondrial IF2 substitutes for the IF1 function in Escherichia coli

Mitochondrial translation machinery exhibits similarities with the bacterial translation apparatus. Of the three bacterial translation initiation factors (IF1, IF2 and IF3), two (IF2 and IF3) have hom...

microbiologyresearch.org

Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by Micromonospora sp. RV43

The urgent need for new antibiotics emphasizes the importance of investigating the many biosynthetic gene clusters that remain silent under standard culture conditions and of assigning functions to th...

microbiologyresearch.org

A set of genetic tools for use in Clostridioides difficile and related species

The Clostridia are a phylogenetically diverse group of anaerobic, spore-forming bacteria that include species of medical, veterinary and industrial importance. The last two decades have seen major adv...

microbiologyresearch.org

Killing of Coccidioides by drugs

Coccidioidomycosis has long been regarded as one of the most difficult mycoses to eradicate in patients with progressive infection. There are few published studies of inhibition of Coccidioides in vit...

microbiologyresearch.org

Microbial Primer: Bacterial DNA supercoiling

DNA in most bacterial cells is maintained in an underwound state. The DNA double helix responds to underwinding by adopting a minimum energy conformation through the supercoiling of the duplex, the fo...

microbiologyresearch.org

Microbe Profile: Candidozyma auris: an emergent and resilient yeast and new antifungal strategies

Candidozyma auris is an emerging opportunistic yeast that is important because of its multidrug resistance, persistence in healthcare environments and ability to cause outbreaks. Since its discovery i...

microbiologyresearch.org

Divergent and overlapping roles of homospermidine and spermidine in Sinorhizobium meliloti physiology and symbiotic performance

Unlike most rhizobia, Sinorhizobium meliloti produces spermidine (Spd) in addition to putrescine (Put) and homospermidine (HSpd) as soluble intracellular polyamines. To investigate their roles, we ana...

microbiologyresearch.org

Synergistic interactions of ruthenium-based carbon monoxide-releasing molecules and antibiotics in their effects on Escherichia coli

The emergence of antibiotic-resistant pathogenic bacteria poses a major and growing public health risk. Because antibiotics act on specific molecular targets, bacteria may evolve resistance mechanisms...

microbiologyresearch.org

D-amino acid substitution and cyclization enhance the stability and antimicrobial activity of arginine-rich peptides

Cationic peptides, particularly those rich in arginine and/or lysine residues, are usually promising antimicrobial agents effective at low concentrations in laboratory settings. However, their applica...

microbiologyresearch.org

Molecular surveillance of foodborne bacterial pathogens and resistome in food products from Hong Kong

Foodborne infections pose an increasing public health challenge worldwide. The problem has been aggravated by the dissemination of antimicrobial resistance genes among zoonotic pathogens, which result...

microbiologyresearch.org

Microbial Primer: Ancientbiotics – making modern antimicrobials from historical infection remedies

The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus...

microbiologyresearch.org

Extensive hidden prophage diversity in Enterobacter species reveals host specificity and local distribution

Bacteriophages are key drivers of bacterial evolution, particularly through their integration as prophages within host genomes. However, the diversity and host specificity of prophages in relevant pat...

microbiologyresearch.org

Sigma B regulated motility and chemotaxis in Bacillus cereus

This study describes an alternative role of the general stress response (GSR) regulated by Sigma B, via the two-component system RsbKY, which is methylated via RsbM, in motility regulation for the per...

microbiologyresearch.org

Microbe Profile: Paracoccus denitrificans - a versatile model

Paracoccus denitrificans is a metabolically versatile alphaproteobacterium first isolated in 1910 by Martinus Beijerinck. Similarities between the aerobic respiratory chain and membrane composition of...

microbiologyresearch.org

Improving a Tn7-based luciferase reporter system for promoter activity studies

Single-copy chromosomal integration systems are essential tools for stable gene expression in bacteria, minimizing variability associated with plasmid-based systems. The Tn7 transposon-based system is...

microbiologyresearch.org

Variations in carbapenem resistance associated with the VIM-1 metallo-β-lactamase across the Enterobacterales

The VIM-1 metallo-β-lactamase enzyme, encoded within class 1 integrons, is found in Gram-negative clinical isolates worldwide and has been linked to outbreaks of bacterial pathogens in nosocomial sett...

microbiologyresearch.org

Annual Conference 2026

Industry opportunities

microb.io

The glucose uptake inhibitor SgrS is induced by D-serine yet does not contribute to growth arrest in enterohaemorrhagic Escherichia coli

Bacterial pathogens sense and respond to host-derived metabolites to regulate virulence and establish successful infections. d-Serine, an amino acid abundant in some extraintestinal environments but s...

microbiologyresearch.org

Strain-dependent contribution of the AcrAB-TolC efflux pump to Klebsiella pneumoniae physiology

Klebsiella pneumoniae is a prominent opportunistic pathogen increasingly associated with multidrug resistance and virulence. One of the main mechanisms of antimicrobial resistance in K. pneumoniae is ...

microbiologyresearch.org

Animal modelling with the Francisella tularensis subspecies holarctica strain OR96-0246

Tularemia is a zoonotic disease caused by Francisella tularensis. Most human cases are caused by F. tularensis ssp. tularensis (type A) or F. tularensis ssp. holarctica (type B), with the former consi...

microbiologyresearch.org

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model

The Staphylococcus aureus type VIIb secretion system (T7SSb) is a multiprotein secretion system that secretes toxins with antibacterial activity, but which is also required for full virulence in anima...

microbiologyresearch.org

Cas9 modulates Campylobacter jejuni virulence traits inside intestinal epithelial cells

The CRISPR-associated protein 9 (Cas9) produced by disease-associated strains of Campylobacter jejuni contributes to full virulence, including immune evasion and bacterial survival inside eukaryotic c...

microbiologyresearch.org

Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimized phage isolation

Phage therapy is a promising treatment for multidrug-resistant bacterial infections. Due to their high host specificity, phages must be matched to the target clinical strains. Efficiently identifying ...

microbiologyresearch.org

Identification and functional analysis of two oligopeptide transporters supporting the growth of Lacticaseibacillus paracasei strain Shirota in milk

Oligopeptide transporters are important proteins in several lactic acid bacteria (LAB) that facilitate the transport of oligopeptides, the primary nitrogen source for growth in milk. Although the prot...

microbiologyresearch.org

Interpretation guidance for MHRA regulatory considerations for phage therapeutic products

On 4 June 2025, the MHRA published ‘Regulatory considerations for therapeutic use of bacteriophages in the UK’. This was in response to recommendations made by the House of Commons Science, Innovation...

microbiologyresearch.org

Microbial Primer: Artificial intelligence for microbiologists

Artificial intelligence (AI) and machine learning (ML) are reshaping microbiology, enabling rapid antibiotic discovery, resistance prediction and clinical diagnostics. For microbiologists, the goal is...

microbiologyresearch.org

Mutations in the Esx-3 secretion system confer resistance to multiple chemical scaffolds in Mycobacterium tuberculosis

We determined the mechanism of resistance to seven chemical series with potent activity against Mycobacterium tuberculosis. Resistant mutants were isolated against the aminothiazoles, phenylhydrazones...

microbiologyresearch.org

Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria

Cellular proliferation relies on the successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilize regulatory pathways that ensure DNA repli...

microbiologyresearch.org

Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory

Streptomyces formicae KY5 was isolated from a Tetraponera penzigi plant-ant nest. It is primarily known for its production of the formicamycins, antibiotics with potent activity against Gram-positive ...

microbiologyresearch.org

Seaweed exposure modulates Escherichia coli plasmid conjugation rate

Seaweeds are a common and diverse component of coastal ecosystems and are known to be associated with Escherichia coli due to faecal pollution. As a biotic substrate, beach-cast seaweed may affect bac...

microbiologyresearch.org