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APS Support UK

@apssupportuk.bsky.social

APS Support UK is dedicated to raising awareness of antiphospholipid syndrome (APS), supporting anyone affected by the condition and furthering research.

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APS Support UK@apssupportuk.bsky.social · 4d ago

Cryptogenic stroke/TIA + persistent aPL (n=47): recurrent ischaemic stroke incidence 0.045/person-year with weak vs 0.169 with strong positivity (HR 3.93; p=.03). Retrospective single-centre study; larger prospective studies needed. pubmed.ncbi.nlm.nih.gov/42668533/

Management and outcomes in patients with cryptogenic stroke and weakly positive antiphospholipid antibodies - PubMed

Most patients with cryptogenic stroke and weakly positive aPLs received antiplatelet agents. Patients with weakly positive aPLs had a lower incidence of recurrent stroke compared with patients with strongly positive aPLs, despite less intensive antithrombotic therapy.

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 6d ago

UK multicentre retrospective study of 897 patients with unprovoked VTE: APS was diagnosed in 11.7%. Universal aPL testing identified more #APS than selective testing (15.8% vs 5.8%). Clinical features alone poorly predicted APS. Prospective studies are needed: www.jthjournal.org/article/S153...

Prevalence and outcomes of antiphospholipid syndrome after unprovoked venous thromboembolism: a multicenter real-world data analysis

Guidance for antiphospholipid antibody (aPL) testing after unprovoked venous thromboembolism (VTE) is inconsistent. Real-world data on the prevalence and outcomes of antiphospholipid syndrome (APS) in...

jthjournal.org

APS Support UK@apssupportuk.bsky.social · 7d ago

New meta-analysis of 24 studies evaluating the 2023 ACR/EULAR APS criteria: pooled sensitivity 74%, specificity 99%. Sensitivity was lower in obstetric APS (20–31%) vs thrombotic #APS (82%), reinforcing their role as classification, not diagnostic, criteria: pubmed.ncbi.nlm.nih.gov/42615990

Classification performance of the 2023 ACR/EULAR antiphospholipid syndrome criteria: a systematic review and meta-analysis - PubMed

The 2023 ACR/EULAR APS classification criteria exhibit consistently excellent specificity but reduced and phenotype-dependent sensitivity. These findings reinforce the intended role of the criteria for classification rather than clinical diagnosis and highlight important limitations in specific APS …

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2w ago

New #APS research combines bulk & single-cell transcriptomics, CMap screening and molecular docking. Type I interferon signalling and myeloid-like B-cell reprogramming emerged as candidate therapeutic axes. Hypothesis-generating; clinical validation needed: pubmed.ncbi.nlm.nih.gov/42647509/

Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome - PubMed

Antiphospholipid syndrome (APS) lacks disease-modifying targeted therapies, and its molecular heterogeneity remains poorly characterized. We employed an integrative systems pharmacology approach combining weighted gene co-expression network analysis (WGCNA), single-cell RNA sequencing, Connectivity …

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 3w ago

New research highlights lengthy waits for #autoimmune and rheumatological diagnoses in Wales, with the Welsh sample reporting an average wait of around 11 years. APS isn’t specifically discussed, but the wider issue of earlier diagnosis matters. pembrokeshire-herald.com/136625/patie... #NHSWales

Patients in Wales waiting years for autoimmune diagnosis

Study led by Swansea University says long delays, limited specialist access and referral barriers are leaving some patients worse off than those elsewhere in the UK PEOPLE in Wales with autoimmune and...

pembrokeshire-herald.com

APS Support UK@apssupportuk.bsky.social · 4w ago

IVIG was used as bridging strategy in a patient with high-risk #AntiphospholipidSyndrome, infected cutaneous ulceration & severe thrombocytopenia. Platelets recovered & ulcers healed over 5 months. A single case, but an interesting risk-adapted approach: pubmed.ncbi.nlm.nih.gov/42582285

Case Report: IVIG as a bridging strategy in high-risk antiphospholipid syndrome with infected cutaneous ulceration and thrombocytopenia - PubMed

This case supports the feasibility of IVIG as a bridging immunomodulatory strategy in high-risk APS cutaneous disease where standard therapies are contraindicated by concurrent infection and thrombocy...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · last mo.

Meta-analysis: retinal toxicity linked to #hydroxychloroquine was uncommon in the first 5 years but rose with longer use and higher doses. Screening can detect changes before vision is affected. Do not alter treatment without clinical advice. www.medpagetoday.com/rheumatology... #APS #Retinopathy

Retinopathy Risk With Long-Term HCQ Treatment Detailed in Meta-Analysis

Eye damage remains uncommon after 15 years, but certain factors increase the risk

medpagetoday.com

APS Support UK@apssupportuk.bsky.social · last mo.

New mini review: what is known about #AntiphospholipidAntibodies and #AtrialFibrillation? It also outlines the ongoing TaPL-AF study, examining aPL prevalence, outcomes and anticoagulant effectiveness. Study design, not results: pubmed.ncbi.nlm.nih.gov/42349513

Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design - PubMed

Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies that target phospholipids and phospholipid-binding proteins, and are identified clinically by anticardiolipin, anti-β2-gly...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · last mo.

A study of 1.25m immune cells found 1,000+ genetic switches that behaved differently by biological sex—new clues to sex differences in #autoimmune risk and a case for inclusive research. scitechdaily.com/scientists-u...

Scientists Uncover Hidden Biological Differences Between Men and Women’s Immune Systems

A massive single-cell study has revealed hidden genetic differences in male and female immune systems that may shape disease risk in unexpected ways.

scitechdaily.com

APS Support UK@apssupportuk.bsky.social · last mo.

@eular.org: in 1,494 rheumatology visits, missing disease-activity records drove ~90% of treat-to-target non-adherence—highlighting a gap between guidance and care: www.news-medical.net/news/2026060... #Rheumatology #EULAR

Real-world study exposes suboptimal adherence to treat-to-target rheumatic strategies

EULAR - The European Alliance of Associations for Rheumatology - acknowledges the role of diverse real-world data to complement knowledge from randomized controlled trials.

news-medical.net

APS Support UK@apssupportuk.bsky.social · last mo.

Study of 985 asymptomatic aPL carriers: low-dose aspirin use was associated with better thrombosis-free survival, with no clear increase in serious bleeding. Retrospective data cannot prove causation: pubmed.ncbi.nlm.nih.gov/42391704/ #AntiphospholipidSyndrome #Thrombosis #Aspirin

Effectiveness and safety of primary thromboprophylaxis in antiphospholipid antibody carriers by serological 2023 ACR/EULAR domains - PubMed

Low-dose aspirin may lower thrombotic risk without increasing bleeding in asymptomatic aPL carriers, even in those with <3 laboratory points. P2Y12 inhibitors demonstrated reduced efficacy and an incr...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · last mo.

New research suggests some people diagnosed with #ObstetricAPS may experience a first #thrombosis years later. This small retrospective study cannot predict individual risk, but supports long-term, individualised follow-up: pubmed.ncbi.nlm.nih.gov/42333063/ #APSResearch #AntiphospholipidSyndrome

Longitudinal observation of thrombotic events in patients with obstetric antiphospholipid syndrome - PubMed

ObjectiveWe aimed to investigate the long-term thrombotic outcomes in patients with obstetric antiphospholipid syndrome (OAPS) who initially presented without thrombosis and to identify clinical featu...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

New case report: a patient with #CatastrophicAntiphospholipidSyndrome, diffuse alveolar haemorrhage and multiorgan involvement survived following intensive multidisciplinary care. The authors highlight early recognition and rapid treatment. pubmed.ncbi.nlm.nih.gov/42340866/ #APS #Thrombosis

Survival After Catastrophic Antiphospholipid Syndrome With Diffuse Alveolar Hemorrhage - PubMed

Antiphospholipid syndrome is a systemic autoimmune disorder characterized by thrombotic events in the presence of antiphospholipid antibodies including lupus anticoagulant, anticardiolipin, and anti-β...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

New research in primary #Sjögren disease found that CD4+ T cells may activate fibroblasts, amplifying inflammation. The work was mainly in mice, with supporting human tissue findings. Sjögren’s can occur alongside APS, but APS was not studied. www.eurekalert.org/news-release... #AutoimmuneDisorders

Immune cell–fibroblast crosstalk may be the key trigger of autoimmune diseases

Sj&ouml;gren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients&rsquo; quality of life. While CD4+ T cells are key drivers of immune-mediated tissue damage and...

eurekalert.org

APS Support UK@apssupportuk.bsky.social · 2mo ago

New meta-analysis of 51 studies (34,623 people): #APS was associated with an approximately 2–3-fold higher risk of recurrent #VTE after anticoagulation stopped. APS remains an acquired thrombophilia associated with VTE, not an inherited thrombophilia. pubmed.ncbi.nlm.nih.gov/42448302/ #Thrombosis

Recurrent VTE in patients with thrombophilia after stopping anticoagulation - A systematic review and meta-analysis - PubMed

The role of thrombophilia in clinical decision making regarding secondary venous thromboembolism (VTE) prevention is still uncertain. Therefore, we aimed to investigate the association between heredit...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

At last: a long-term #ObstetricAPS study. Over a median 17-year follow-up, 15.7% of 114 participants with obstetric APS developed thrombotic APS. The authors highlight follow-up after pregnancy and the need for prevention research. pubmed.ncbi.nlm.nih.gov/42433136/ #APSResearch

Thrombotic Antiphospholipid Syndrome: A Long Term Follow-up of Patients With Recurrent Pregnancy Loss and Antiphospholipid Antibodies From the APS 1994 Study - PubMed

Patients with RPL and aPL who exhibit the identified risk factors should undergo subsequent follow-up after pregnancy. Further research is required to investigate the potential for thrombosis preventi...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

New case report: NBTE, a rare APS-related heart-valve complication, caused severe mitral narrowing, heart failure & stroke. The authors highlight echocardiography and multidisciplinary care; symptoms and scan findings improved at 6 months. pubmed.ncbi.nlm.nih.gov/42394726/ #AntiphospholipidSyndrome

Nonbacterial thrombotic endocarditis in antiphospholipid syndrome, presenting with severe mitral stenosis, heart failure, and stroke: case report - PubMed

NBTE should be considered in APS patients presenting with cardiac murmurs and embolic events. TTE is essential for diagnosis. This case underscores the importance of prompt identification and a multid...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

We're delighted to support Megan Preece and Catherine Ducker from @imperialcollegeldn.bsky.social with APS Support UK travel grants to attend #ISTH2026 in Paris (11–15 July). We wish them every success and look forward to hearing about the congress: www.isthcongress.org #APSResearch

ISTH Congress | Thrombosis and Hemostasis Conference

The Congress is the premier international medical and scientific conference for experts in the fields of thrombosis, hemostasis and vascular biology. Join us July 11-15 in Washington, D.C., for this m...

isthcongress.org

APS Support UK@apssupportuk.bsky.social · 2mo ago

New study: Borrelia infection may trigger transient aPL/antilipid antibodies, as can happen in some cancers/other illnesses. APS requires persistently positive tests + clinical features. pubmed.ncbi.nlm.nih.gov/42402029/

Antiphospholipid antibodies in acute and post-treatment Lyme disease - PubMed

Acute Lyme disease is caused by a <i>Borrelia</i> infection and typically responds to antibiotic treatment, but post-infectious chronic symptoms are common. The precise origin of these post-treatment ...

pubmed.ncbi.nlm.nih.gov

APS Support UK@apssupportuk.bsky.social · 2mo ago

#ObstetricAPS is increasingly understood as a distinct, multifactorial subtype—not solely placental #thrombosis. It highlights trophoblast dysfunction, inflammation and decidual changes as key areas for future research: www.sciencedirect.com/science/arti... #AntiphospholipidSyndrome

Obstetric antiphospholipid syndrome: Advances in pathogenesis

The publication of the 2023 ACR-EULAR classification criteria for antiphospholipid syndrome (APS) has shifted the understanding of APS from a “one-siz…

sciencedirect.com

APS Support UK@apssupportuk.bsky.social · 2mo ago

New #APS research: ultrasound-measured common femoral vein wall thickness was higher in APS patients than controls or chronic non-inflammatory #DVT patients. Authors suggest VWT may be a useful adjunct when diagnosis is uncertain. Abstract: pubmed.ncbi.nlm.nih.gov/42370504/ #thrombosis

Common femoral vein wall thickness in antiphospholipid syndrome: a potential imaging biomarker - PubMed

In patients with uncertain APS diagnosis based on clinical manifestations and/or aPL positivity, measurement of VWT by ultrasonography may serve as a useful adjunctive tool in the diagnostic process.

pubmed.ncbi.nlm.nih.gov