Sometimes scientific questions drive us in a quest for unexpected concepts that require new partners. When asking "how do polyamines signal" we opened a door leading to an 8-year research project, that now leaves us with more questions than answers (as good projects should do). rdcu.be/eY5gS
Polyamine-dependent metabolic shielding regulates alternative splicing
Nature - Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing...
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