🔥off the press Health-related quality of life in participants with advanced biliary tract cancer from the phase III KEYNOTE-966 study @JHepatology doi.org/10.1016/j.jh... 👉Health-related quality of life maintained after adding pembrolizumab to GemCis @myESMO @EASLedu @ILCAnews @curecc

🔥off the press Liposomal irinotecan for previously treated pts with BTC: A pooled analysis of NIFTY & NALIRICC @JHepatology 🔎🇩🇪&🇰🇷 co-production 👉sig. ORR & PFS benefit 👉trend for OS 🤔Is there a role for Irino in BTC? 😅decide for yourself... @myESMO @EASLedu @ILCAnews @cure

🔥Nivolumab and Ipilimuma approved by EMA for advanced hepatocellular carcinoma 🔥 👇https://ec.europa.eu/health/documents/community-register/html/h1014.htm 👉great news for our patients > more options in 1st line 😅amazing: approval in 🇪🇺by EMA before 🇺🇸by FDA @myESMO @EASLedu @ILCAnews #livertwitter

🔥off the press Precision surgery for hepatocellular carcinoma @LancetGastroHep doi.org/10.1016/S246... 👉the field is moving to precision medicine 👉Our thoughts on current strategies & future opportunities > team work is key for personalized therapy @myESMO

A phase III randomised study of first-line NUC-1031/ cisplatin vs GemCis in advanced biliary tract cancer @JHepatology doi.org/10.1016/j.jh... 👉mOS 9.2 vs 12.6 mo 👉Early toxicity & liver injury in exp. arm 😨Not only 🚫, but even detrimental @myESMO @EASLedu @ILCAnews

🔥off the press Recent advances in systemic therapy for advanced biliary tractcancer: A systematic review & meta-analysis usingreconstructed RCT survival data @JHEP_Reports 👇now online available doi.org/10.1016/j.jh... 👉very modest progress 🧐we need biomarker & better 💊 @myESMO @EASLedu

Next-Generation Sequencing–Based MSI Scoring Predicts Benefit in Mismatch Repair–Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D @CCR_AACR doi.org/10.1158/1078... 👉not all MSI tumors respond to ICI 👉NGS & RNA seq can help to identify responders @myESMO

Neoadjuvant mFOLFOX With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer @Annals_Oncology doi.org/10.1200/JCO-... 🔎10-yr Follow-Up of FOWARC trial 🧐neoadjuvant mFOLFOX6 is a therapeutic option in LARC

🔥off the press New systemic treatment paradigms in advanced biliary tract cancer and variations in patient access across Europe @LancetRH_Europe doi.org/10.1016/j.la... 👉there are striking disparities in access to innovative💊& molecular testing 🧐we urgently need a more harmonised path forward

Tremelimumab & durvalumab as neoadjuvant or non-operative management strategy for MSI GC/GEJ cancer @Annals_Oncology doi.org/10.1016/j.an... 🔎 INFINITY study by GONO 👉17 pts > 13 cCR > non-operative management > only 1 recurrence 🧐W&W in GC/GEC ... exciting @myESMO

Pembrolizumab versus chemotherapy in MSI colorectal cancer @Annals_Oncology doi.org/10.1016/j.an... 🔎5-yr follow wo KEYNOTE-177 👉mPFS 16.5 vs 8.2 mo 👉mOS 77.5 vs 36.7 mo (37% cross over) 👉5-year OS rate: 54.8s% v 44.2% 🧐we need biomarker .. Nivo/Ipi vs pembro @myESMO

Clinicogenomic landscape of #PDAC identifies KRAS mutant dosage as prognostic of overall survival @NatureMedicine doi.org/10.1038/s415... 👉Very comprehensive analysis on the impact of KRAS 👉Key for understanding de novo and acquired resistance to RAS 💊 @myESMO

🔥off the press: Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up @Annals_Oncology doi.org/10.1016/j.an... 👉get the lastest update on HCC management 👉Multiple options > MDT is key @myESMO @EASLedu @ILCAnews #livertwitter

Advances in liquid biopsy: From exploration to practical application @Cancer_Cell doi.org/10.1016/j.cc... 👏Excellent review on liquid biopsy 👉LP will be key for disease monitoring and to understand resistence mechanisms @myESMO

Liver metastases do not predict resistance to the addition of atezolizumab to FOLFOXIRI + bevacizumab in proficient MMR mCRC @ESMO_Open doi.org/10.1016/j.es... 🔎 Post-hoc AtezoTRIBE study 👉LM prognostic, not predictive 🧐Do we need to rethink LM & ICI efficacy in mCRC? @myESMO

Long-term outcomes in patients with advanced intrahepatic cholangiocarcinoma treated with hepatic arterial infusion chemotherapy @JNCI_Now doi.org/10.1093/jnci... 🔎🇺🇸RWD, >200pts 👉HAI with CTx can offer long-term durable disease control: mOS >20mo @myESMO @EASLedu @ILCAnews #livertwitter

🔥hot off the press @ESMO_Open doi.org/10.1016/j.es... ESMO Clinical Practice Guideline interim update on the treatment of locally advanced oesophageal and oesophagogastric junction adenocarcinoma and metastatic squamous-cell carcinoma 👉get the latest update on management @myESMO

Atezolizumab Plus CTx With or Without Bevacizumab in BTC 🔎 Clinical & Biomarker Data From Phs II IMbrave151 Trial @JCO_ASCO 👉ORR 26 vs 26% 👉mPFS 8.3 vs 7.9 mo 👉mOS 14.9 vs 14.6 mo 👉High VEGFA may be a predictive biomarker 🧐❌trail, not sure whether to proceed...

Trial of Gemcitabine, Cisplatin & Nab-Paclitaxel vs Gemcitabine/ Cisplatin in BTC @JCO_ASCO doi.org/10.1200/JCO-... 🔎SWOG S1815 phs III 👉ORR 31 vs 21 % 👉mPFS 7.5 vs 6.3 mo 👉mOS 14 vs 13.6 mo 🧐🚫 trial, maybe an option subgroups such locally advanced or gallbladder

Mismatch repair andMSI phenotypes across solid tumors: A comprehensive cBioPortal study on prevalence & prognostic impact European Journal of Cancer doi.org/10.1016/j.ej... 🔎🗺️RWD, 23.893 pts 👉MMR-m status not associated with MSI in 48.9 % of cases 🧐need of comprehensive testing

Baseline Liquid Biopsy in Relation to Tissue-Based Parameters in mCRC @JCO_ASCO doi.org/10.1200/JCO.... 🔎FIRE-4 (AIO-KRK-0114) Study 👉LB allows detection of RAS/ BRAF must in pt deemed RASwt on basis of tissue > behave like RAS/BRAF muts... 🧐Better to know..supports LB...…

Combined Analyses of ctDNA &Immunoscore in Stage III Colon Cancer 🔎Post Hoc of PRODIGE-GERCOR IDEA-France/ HORG-IDEA-Greece Trials @JCO_ASCO doi.org/10.1200/JCO.... 👉ctDNA in 19.7% of pts > independent prognostic 🖍️ 👉IS additional prognostic info in 80% 🧐Time for implantation in clinical practice..

fficacy of Zenocutuzumab in NRG1 Fusion–Positive Cancer @NEJM doi.org/10.1056/NEJM... 🔎Ph2-2, 204 pts, 12 tumor types 👉 bispecific antibody against HER2 & HER3, 👉ORR 30%, DoR 11.1 mo, mPFS 6.8 mo 👉ORR 40% in #PDAC, 20% in BTC 🧐Effective.. @myESMO @EASLedu @ILCAnews

Claudin 18.2-targeting antibody–drug conjugate CMG901 in patients with advanced GC/GEJ cancer @lancet oncology doi.org/10.1016/ S1470-2045(24)00636-3 🔎 KYM901 phs 1 trial 👉ORR 29%, DCR 68% 👉SAE ≥3 68% 👉first CLDN18.2- specific ADC 🧐Phs 3 ongoing...

Thermal ablation versus surgical resection of small-size colorectal liver metastases @TheLancetOncol doi.org/10.1016/S147... 🔎COLLISION phs 3 non-inferiority trial, 300 pts 👉 stopped early 👉SAE 7 vs 20% 👉Similar OS and local control 🧐Both are effective treatment options

🔥off the press Pfizer’s BRAFTOVI® Combination Regimen Significantly Improved Progression-Free Survival and Overall Survival in Phase 3 BREAKWATER Trial 👉Just published in Nature Medicine 👉now press release: both end points positive. 🧐Practice changing.... @myesmo

Tiragolumab in combination with atezolizumab and bevacizumab in advanced or metastatic HCC @TheLancetOncol doi.org/10.1016/S147... 🔎 MORPHEUS-Liver phs 1b–2, 59 pts 👉ORR 43% vs 11% 👉mPFS 12.3 vs 4.2 mo 👉mOS 28.9 vs 15.1 mo 🧐anti-TIGIT looks really promising @myESMO @EASLedu @ILCAnews

🔥off the press Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data @JHEP_Reports doi.org/10.1016/j.jh... 👉Many trials in 1st line BTC, but not much progress 🤨we need to do better @myESMO @EASLedu

Utility of methylated DNA markers for the diagnosis of malignant biliary strictures doi.org/10.1097/HEP.... @HEP_Journal 👉identification of malignant biliary strictures is challenging 👉Bile can be valuable for NGS & methylated DNA markers @myESMO @EASLedu @ILCAnews #livertwitter @curecc

The impact of neoadjuvant therapy in patients with left-sided resectable #PDAC @Annals_Oncology doi.org/10.1016/j.an... 🔎international multicenter study2,282 pts 👉Neoadj. CTx improves OS for left-sided PDAC 👉higher benefit in pts w/ large tumors & high CA19-9 🧐We need prospective studies @myESMO