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Arrosan Rajalingam

@arrosan.bsky.social

Doctoral Student | Hajime Murakami Lab @aberdeenuni | Meiosis | Mitotic recombination | axis proteins | @CheveningFCDO @GenSocUK @BiochemSoc

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Hajime Murakami@alhajijoker.bsky.social · 4w ago

Happy to share the first preprint from our lab, led by @arrosan.bsky.social, in collaboration with @ccb-lab.bsky.social. We identify a conserved cohesin-interacting motif in Red1 required for its recruitment, DSB formation, and Mek1 activation. www.biorxiv.org/content/10.6... #meiosis #recombination

Cohesin–axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation

Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

biorxiv.org

Arrosan Rajalingam@arrosan.bsky.social · 10mo ago

I remember presenting this paper from @hunterlab.bsky.social in our journal club a year ago, when it was still on bioRxiv. I’m delighted to see it now published in Nature! www.nature.com/articles/s41... #Cohesion #Development #Genomicinstability #Meiosis

Protecting double Holliday junctions ensures crossing over during meiosis - Nature

Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.

nature.com