Asael Roichman
@asaelroichman.bsky.social
Postdoc in Josh Rabinowitz's lab at Princeton University, studying how diet affects cancer therapy
Now online! Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
Diet can impact anticancer drug activity. A classic example in rodents is a ketogenic diet enhancing PI3K inhibitor activity. Here, we show that phytochemicals and their microbiome derivatives, rather than macronutrient composition, underlie this phenomenon.
dlvr.it
Thrilled to share that my main postdoctoral project in Josh Rabinowitz’s lab is out today at @cp-cell.bsky.social ! We found an unexpected, diet- and microbiota-dependent mechanism that affects the anticancer activity of PI3K inhibitors. Thread below 👇
Happy to share our effort to better understand how dietary fiber impacts metabolite levels and cancer immunotherapy www.biorxiv.org/content/10.1...
Lack of consistent effect of dietary fiber on immune checkpoint blockade efficacy across diverse murine tumor models
Immune checkpoint blockade (ICB) has transformed cancer treatment, but success rates remain low in most cancers. Recent research suggest that dietary fiber enhances ICB response in melanoma patients a...
biorxiv.org
Excited to speak at #LifeSciencesSymposium2025 on March 27! 🧬🔬 Join me and leading Israeli researchers & postdocs worldwide as we explore cutting-edge science and breakthroughs. Don’t miss this online event—register now! www.scienceabroad.org.il/life-science... @ScienceAbroad
