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Anthony Schuller

@aschuller17.bsky.social

Director of Biology @ Interdict Bio | Previously @ Nogales Lab (Berkeley), Schwartz Lab (MIT), Green Lab (Johns Hopkins) | Drug discovery, ribosomes, protein & RNA biochemistry, cryo-EM, cryo-ET.

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Anthony Schuller@aschuller17.bsky.social · 5mo ago

Incredibly proud of our small but mighty team at Interdict Bio as we bring the interdictor modality closer to the clinic! Check out our first publication that lays the foundation for context-dependent translation modulators as a therapeutic approach for cancer! www.nature.com/articles/s41...

Context-dependent translation inhibition as a cancer therapeutic modality - Nature Communications

Robust protein synthesis by the ribosome is required for rapid cancer growth. Here authors present interdictors, small molecule inhibitors of protein synthesis with context-dependent activity that inh...

nature.com

Anthony Schuller@aschuller17.bsky.social · 2y ago

Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers! #ribosome #interdictor Check out the preprint here: www.biorxiv.org/content/10.1...

Context-dependent translation inhibition as a novel oncology therapeutic modality

Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

biorxiv.org