New ADPKD #basicresearch identifies the PTH–Pth1r–primary cilia pathway as a driver of kidney cyst growth. Blocking Pth1r reduced cyst progression in mouse models, while cinacalcet lowered PTH levels and cyst burden, highlighting a promising new therapeutic target. #ASNJASN kidney.pub/JASN1170?...

Let's talk about sex. A fascinating review in #ASNCJASN highlights that potassium (K⁺) regulation is not one-size-fits-all. Evolution has shaped distinct physiological strategies in women and men to maintain electrolyte balance and meet the demands of reproduction. kidney.pub/CJASN1154...

The August issue of #ASNKidneyNews is now online! Explore the second of a two-part special section on Innovation in Medical Education, catch up on notable business activities, and dive into a new case with Detective Nephron. Read the issue: kidney.pub/KN1808-01... @kdjhaveri.bsky.social

APOL1 risk variants (G1/G2) form membrane pores that increase Ca²⁺ influx and kidney cell damage. The APOL1 inhibitor VX-147 and the M1 (N264K) variant reduced Ca²⁺ entry and improved cell survival, highlighting potential therapies for APOL1 kidney disease. #ASNJASN kidney.pub/JASN1159?...

Hemodialysis triggers significant glucose fluctuations, with levels falling during treatment and rebounding afterward in patients with and without diabetes. A new study in #ASNCJASN highlights dialysis as a major stressor on glucose regulation and homeostasis. kidney.pub/CJASN1119...

People with CKD want treatments that help them live, work, socialize, and spend time with family. SONG-LP is a reliable, validated tool that measures life participation—an outcome that matters most to patients. #ASNKidney360 #CKD #PatientCenteredCare kidney.pub/KID1247?u...

August issue of JASN is now available online! Topics covered include: - Calorie Restriction in a Mouse Model of UMOD-Related Kidney Disease - Community/EMR Approach to APOL1 Screening for RCT in APOL1-Mediated Kidney Disease kidney.pub/JASN-0826... #ASNJASN Cover by Ha et al.

Contact JASN Editor-in-Chief by August 6 with your late-breaking clinical trial for expedited consideration and peer review. If accepted, your article will publish online simultaneously with #KidneyWk. Learn more: bit.ly/JASNLBCT?utm_...

Nephrologists are uniquely positioned to prevent recurrent kidney stones by identifying and managing the metabolic drivers of stone disease. Yet many graduating fellows report low confidence in nephrolithiasis management. Read the full article in #ASNKidneyNews: kidney.pub/KN1807-17...

Is it time for clinicians to rethink “fistula first” for every older dialysis patient? The best access may be the one that aligns with the patient’s health, priorities, and quality of life, according to new research published in #ASNJASN. kidney.pub/JASN1160?... @hswapnil.bsky.social

A history of pregnancy complications alone may not predict worse kidney outcomes in living kidney donors, according to study in #ASNKidney360. Should we rethink excluding otherwise healthy women from donation based primarily on adverse pregnancy history? kidney.pub/KID1277?u...

#BasicResearch study in #ASNJASN shows that blocking gut microbial TMAO production reversed key features of established CKD in mice, further implicating the gut-kidney axis as a promising therapeutic target. kidney.pub/JASN1171?...

Latest ASN Kidney Translation podcast explores advances in Cardiovascular-Kidney-Metabolic syndrome, including building a cardio-nephrology service (Kidney360), cardiorenal benefits of SGLT2 inhibitors & GLP-1 receptor agonists (JASN), & PREVENT risk prediction (CJASN) kidney.pub/KTPOD0629...

The future of kidney medicine is shifting toward prevention. A new #ASNCJASN article highlights why CKM-focused training is essential, preparing fellows to use emerging therapies, collaborate across specialties, and improve kidney, heart, and metabolic health outcomes. kidney.pub/CJASN1132...

New eGFR slope sample size formula for CKD trials highlights that measurement frequency, trial duration, expected slope difference, and dropout patterns interact strongly. Frequent measurements matter most in short trials, while small effects require longer studies. kidney.pub/JASN1157?... #ASNJASN

As use of peritoneal dialysis (PD) continues to grow in the US, education remains a critical bottleneck—for both patients and nephrology trainees. Improving PD proficiency will require innovation in how we teach and train. Read the full article in #ASNKidneyNews: kidney.pub/KN1807-16...

#ASNKidney360 review: Could post-transplant anti-GBM nephritis be the Achilles’ heel of kidney transplantation in Alport syndrome, affecting ~5% of patients and causing rapid allograft loss with recurrence after re-transplantation? kidney.pub/KID1310?u...

CKD-associated osteoporosis reflects impaired bone quality and turnover, not just low BMD. Diagnosis requires integrating PTH, bone turnover markers, and imaging, while treatment in advanced CKD and transplant recipients remains challenging. kidney.pub/KID1303?u... #ASNKidney360

PTH signaling through the ciliary receptor Pth1r promotes cyst growth in ADPKD. Pth1r is upregulated early in disease, and its deletion or PTH lowering with cinacalcet reduces cyst burden, highlighting the PTH-Pth1r-cilia pathway as a potential therapeutic target. kidney.pub/JASN1170?... #ASNJASN

Now more than ever, glomerular disease education needs to lead nephrology training. Read more in #ASNKidneyNews: kidney.pub/KN1807-15...

A negative study, but an important lesson: Measuring kidney tubular secretion years before hospitalization did not predict who developed AKI during acute heart failure. Are we relying too heavily on novel biomarkers when better AKI prediction tools are needed? #ASNKidney360 kidney.pub/KID1263?u...

How do we prepare the next generation of nephrologists for an increasingly complex field? Individualized fellowship tracks offer a way to balance broad clinical training with focused expertise, mentorship, and career development. Read more in #ASNKidneyNews: kidney.pub/KN1807-20...

Expand the reach of your late-breaking clinical trials and submit the manuscript to JASN for rapid consideration, peer review, and potential concurrent online publication with #KidneyWk. ➡️ kidney.pub/LBCT2026?...

New study in #ASNCJASN shows muscle cramps remain a major burden for hemodialysis patients. Among 420 patients, 62% reported cramps at least once and 13% experienced frequent cramps, underscoring the need for strategies to reduce both frequent and occasional cramping. kidney.pub/CJASN1106...

Let's talk about sex. A fascinating review in #ASNCJASN highlights that potassium (K⁺) regulation is not one-size-fits-all. Evolution has shaped distinct physiological strategies in women and men to maintain electrolyte balance and meet the demands of reproduction. kidney.pub/CJASN1154...

Managing blood pressure in hemodialysis isn't as simple as treating hypertension. Clinicians face hundreds of BP readings collected before, during, and after dialysis, with varying reliability and no universally accepted BP target. Read about the challenges in #ASNKidneyNews: kidney.pub/KN1807-13...

Broader screening, earlier diagnosis, and targeted treatment of Primary aldosteronism (PA) have the potential to prevent years of cardiovascular and kidney damage in patients with hypertension according to a new #HowITreat article in #ASNCJASN. kidney.pub/CJASN1165...

Study in #ASNJASN: Adding donor urinary biomarkers (UMOD, OPN, YKL-40) to KDPI improved prediction of kidney transplant outcomes (AUC 0.80→0.86). Even rapid point-of-care testing outperformed KDPI alone, suggesting a practical way to better assess donor kidney quality. kidney.pub/JASN1183?...

Dialysis presents a compelling environment for AI integration, but translation from research settings to clinical practice has been limited. Read about recent research to bridge the gap in #ASNKidneyNews: kidney.pub/KN1807-12...

New ADPKD #basicresearch identifies the PTH–Pth1r–primary cilia pathway as a driver of kidney cyst growth. Blocking Pth1r reduced cyst progression in mouse models, while cinacalcet lowered PTH levels and cyst burden, highlighting a promising new therapeutic target. #ASNJASN kidney.pub/JASN1170?...