Jon Douglas
@atranscendedman.bsky.social
Transparent to the transcendent. Building TrialPilot - https://www.trialpilot.app/ https://fnih.org/patient-engagement/patient-voices-fnih/long-covid-struggle-inspires-urgency/
UCLA, 2 blood donors plus cell models. Delta nucleocapsid bound cGAS, while SARS-CoV-2 nucleocapsid amplified TLR7/8 inflammation in macrophages. Their secretions cut coronary barrier integrity to 47%. www.science.org/doi/10.1126/...
SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages
A coronavirus protein rewires immune signaling, driving inflammation and damaging blood vessels in severe COVID-19.
science.org
Aarhus University Hospital, 50 people with Long COVID. After 1.4 years, myopathic EMG changes fell from 78% to 18%, yet 56% still had abnormal single-fiber EMG and fatigue persisted, suggesting ongoing neuromuscular dysfunction. www.sciencedirect.com/science/arti...
Persistent neuromuscular dysfunction in long COVID: A quantitative and single fiber EMG follow-up study
Persistent symptoms after SARS CoV-2 infection, often designated as "long COVID”, continue to be an ongoing health issue. Previously, we reported elec…
sciencedirect.com
Politecnico di Milano review finds COVID-19 may reshape bone itself. Human synchrotron imaging showed larger, rounder osteocyte spaces, while animal models found lasting trabecular loss, pointing to disrupted bone sensing and repair. www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
frontiersin.org
Jichi Medical University, 29,841 patients. Kawasaki disease rebounded after COVID restrictions eased, rising 166.7% in ages 5 to 9 but 26.1% in infants. This suggests different exposure routes to possible triggers. jamanetwork.com/journals/jam...
Epidemiology of Kawasaki Disease After the COVID-19 Pandemic in Japan 2023-2024
This cohort study describes the incidence of Kawasaki disease overall across 50 years and by age groups to assess whether epidemiologic patterns changed after the COVID-19 pandemic.
jamanetwork.com
Researchers found that activating PD-1 directly suppressed inflammatory T cells in rheumatoid arthritis models and reduced harmful B cell formation, revealing an immune brake that treatment may be able to restore. www.nature.com/articles/s41...
PD-1 agonism puts the brakes on pathogenic T cell responses in RA - Nature Reviews Rheumatology
PD-L2-mediated activation of PD-1 signalling in rheumatoid arthritis suppresses pro-inflammatory cytokine production and regulates pathogenic B cell responses.
nature.com
Universidade Estadual de Santa Cruz studied 50 people and found 7 blood miRNAs were elevated in mild, nonhospitalized COVID. The pattern may reflect early control of inflammation and vessel repair, but gene targets were only predicted. www.biorxiv.org/content/10.6...
Upregulation of distinct miRNAs in SARS-CoV-2 infected individuals: A differential signature of circulating miRNAs
COVID-19 exhibits a broad clinical spectrum, from asymptomatic to severe cases, underscoring the need for molecular biomarkers to support surveillance and early intervention. Here, we profiled circula...
biorxiv.org
University of Gothenburg followed 82 participants, with 59 retested at 3 years. Objective tests showed persistent deficits in attention, processing speed and working memory, while 78% still met the mental fatigue cutoff. medicaljournalssweden.se/jrm/article/...
Neuropsychological consequences three years post-covid-19 are persistent and have great impact on everyday activities | Journal of Rehabilitation Medicine
medicaljournalssweden.se
University of Alabama at Birmingham, 273 participants. An exploratory brain fog cluster had memory problems in 97%, fatigue in 96% and concentration trouble in 94%. Of 32 followed, 44% were not working, half due to COVID symptoms. www.mdpi.com/3042-8637/1/...
mdpi.com
GLP-1 medicines act beyond weight loss, engaging neural, immune, vascular and organ-specific pathways that improve glucose control, inflammation, blood pressure, heart, liver, kidney and mobility. www.cell.com/cell-metabol...
Weight-loss-independent actions of GLP-1 medicines
The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to ...
cell.com
Universiti Putra Malaysia, 24 donors. In vitro, older T2DM serum plus SARS-CoV-2 spike increased vessel leak and adhesion signals, lowered ACE2, and raised Ang II, linking vascular dysfunction to lung cell injury. analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
SARS‐CoV‐2 Spike Protein Exacerbates Endothelial Dysfunction and Promotes Lung Injury in Aging Type 2 Diabetes Mellitus Cell Culture Model
SARS-CoV-2 spike protein (SP) exacerbates diabetes-associated ED, increasing oxidative stress, adhesion molecules, and vascular permeability, leading to inflammation, cytokine release, and lung epith....
analyticalsciencejournals.onlinelibrary.wiley.com
Emory University studied 61 adults. A cough device detected SARS-CoV-2 RNA in lung droplets from 68% of COVID cases, with little upper airway contamination and higher IL-13 and TNF-alpha. www.chestpulmonary.org/article/S294...
Detection of SARS-CoV-2 RNA and Biomarkers in Device-Captured Droplets From the Lung
Our results show that the PneumoniaCheck device is a noninvasive method for successfully detecting SARS-CoV-2 and inflammatory cytokines in specimens from the lower respiratory tract in patients with ...
chestpulmonary.org
If the SAVE America Act is really about saving America, maybe it could start with the 20 million Americans living with Long COVID. www.marshall.senate.gov/newsroom/pre...
Senator Marshall: It’s Time to Get the SAVE America Act on the Senate Floor - Senator Roger Marshall
Senator Marshall: It’s Time to Get the SAVE America Act on the Senate Floor
marshall.senate.gov
Jeffrey Scharoun’s obituary remembers how he supported his brother Dan through Long COVID, staying beside him in the hospital, taking him on drives, and making room for him in his home. www.wjlyonsfuneralhome.com/obituaries/j...
Jeffrey P. Scharoun Obituary July 30, 2026 - W.J. Lyons, Jr. Funeral Home, Inc.
View Jeffrey P. Scharoun's obituary, send flowers, find service dates, and sign the guestbook.
wjlyonsfuneralhome.com
Fourth Military Medical University, 49 students followed for 4 years at high altitude showed persistently unstable connectivity between frontal and auditory brain regions, linked with poorer memory and slower reactions under chronic hypoxia. www.cell.com/iscience/ful...
Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude
Health sciences; Cognitive neuroscience
cell.com
University of Hong Kong. In nasal organoids, Pemivibart lost about 60 to 80-fold potency against XFG and KP.3.1.1, while SA55 stayed potent and topical SA55 cut viral load by over 1,000-fold. www.tandfonline.com/doi/full/10....
Organoid-based evaluation of SA55 and Pemivibart against evolving SARS-CoV-2 variants
Pemivibart, a class 1/4 monoclonal antibody (mAb), is currently the only FDA-authorized SARS-CoV-2 mAb under an Emergency Use Authorization (EUA) in clinical use. The emergence of subvariants, incl...
tandfonline.com
Researchers, 46 countries. Counterfactual modeling estimated COVID-19 cut GDP by 6.32% in 2020 and 2.87% in 2021. Higher debt and stricter measures were linked to larger losses, while vaccination was linked to smaller losses. www.nature.com/articles/s41...
The economic impact of COVID-19: losses and resilience factors - Humanities and Social Sciences Communications
Humanities and Social Sciences Communications - The economic impact of COVID-19: losses and resilience factors
nature.com
Johns Hopkins, 607 adults. Prior SARS-CoV-2 infection was linked to a greater 6-month rise in NT-proBNP, a blood marker of heart wall stress, suggesting subtle cardiac strain even after mild or symptom-free infection. www.researchsquare.com/article/rs-1...
Changes in Subclinical Biomarkers of Myocardial Injury and Inflammation and SARS-COV-2 Serological Analyses in a Cohort of Community-dwelling Adults
COVID-19 has been linked to heart-related complications in patients sick enough to be hospitalized, largely due to the strain severe illness places on the cardiovascular system. Whether milder, commun...
researchsquare.com
La Jolla Institute for Immunology, 120 people. Mapping 1.15 million lung immune cells showed disease-risk variants act in specific resident cells. An IFITM3 risk allele was linked to lower antiviral gene expression, strongest in lung NK cells. www.nature.com/articles/s41...
Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases - Nature Immunology
Schmiedel et al. present a human lung immune cell atlas linking disease-associated genetic variants to gene expression in tissue-resident immune cells.
nature.com
NYU Grossman School of Medicine researchers, using human airway cells, found nicotine raised ACE2 and TMPRSS2 while cotinine boosted cathepsin B spike cleavage. Together they additively increased SARS-CoV-2 entry. journals.asm.org/doi/10.1128/...
Nicotine and cotinine enhance SARS-CoV-2 entry through distinct but complementary mechanisms in human respiratory epithelial cells | Journal of Virology
This study highlights the potential risks of tobacco and E-cigarette use in increasing susceptibility to COVID-19. We show that the major neurostimulant in tobacco and E-cigarette, nicotine, and its m...
journals.asm.org
Dalhousie University studied 42 people with Long COVID and 14 controls. MRI found 2 brain subtypes. One had less gray matter in the cerebellum and putamen, suggesting brain fog has differing biological roots. www.biorxiv.org/content/10.6...
Neuroanatomical subtypes of Long COVID reveal distinct cognitive profiles alongside longitudinal brain changes
Background: Long COVID is characterized by persistent symptoms following SARS-CoV-2 infection, including cognitive deficits among its most disabling manifestations. However, their neurobiological basi...
biorxiv.org
University of Southern Santa Catarina, 111 ICU survivors. Low T-helper cytokine activity during acute COVID-19 was linked to poorer lung gas exchange a year later, while high activity was linked to lower airflow. www.heartandlung.org/article/S014...
Early inflammatory profiling identifies patients at risk for persistent pulmonary dysfunction after COVID-19: a cohort study
At the end of 2019, a novel coronavirus, SARS-CoV-2, emerged in China and rapidly spread worldwide, causing COVID-19. Its unprecedented impact highlighted the need to understand its pathophysiology, r...
heartandlung.org
CDC, 575 people with nonhospitalized SARS-CoV-2. Most retained high quality of life, but 38% of adults worsened in the first 2 weeks, mainly pain and limited activity. At 31 to 90 days, 16% remained worse. Vaccination reduced early decline. jheor.org/article/1631...
Estimating Impact of SARS-CoV-2 Infection on Health-Related Quality of Life Among Persons Aged 8 Years and Older, August 2020–July 2022 | Published in Journal of Health Economics and Outcomes Research
By Sheroi Johnson, Huong Q. Nguyen & 16 more. The study suggests that mild COVID-19 has minimal impact on quality of life, but factors like vaccination status, gastrointestinal symptoms, employment st...
jheor.org
University of Liverpool researchers show lab made fibrinaloid microclots have classic amyloid staining. These hard to dissolve clots can form on cell debris and may impair small vessel blood flow in Long COVID. www.cambridge.org/core/journal...
Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases | QRB Discovery | Cambridge Core
Uncovering the hidden biology of fibrinaloid microclot complexes in complex, inflammatory diseases - Volume 7
cambridge.org
Hawaiʻi State Department of Health, 38 long-term care facilities. A 10% relative rise in staff COVID-19 vaccination was linked to 2.7 fewer resident infections per 100 beds, suggesting staff vaccination may help protect residents. www.ajicjournal.org/article/S019...
Relationship between COVID-19 vaccination coverage in residents and staff and COVID-19 outcomes in long term care facilities in Hawai’i, June 2022 - May 2024
COVID-19 mortality rates among long-term care facility (LTCF) residents remain high post-pandemic, signifying this population remains highly vulnerable.
ajicjournal.org
Mie University researchers studied 24 people. ME/CFS blood vesicles were larger and carried a distinct microRNA pattern linked to nerve signaling and cell structure. The finding is promising but needs larger validation. link.springer.com/article/10.1...
Circulating extracellular vesicles-microRNAs as potential biomarkers for the identification of ME/CFS: differentiating fatigue-related conditions - Journal of Translational Medicine
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating, multi-systemic condition that has gained renewed global attention due to its clinical overlap with the growing...
link.springer.com
University of Iowa, 4 to 5 mice per time point showed brain microglia stayed inflamed for 100 days after SARS-CoV-2, despite no productive brain infection. Mitochondrial genes fell, suggesting stressed immune cells may sustain neuroPASC. www.nature.com/articles/s41...
Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis - Nature Communications
While prolonged neuroinflammation is considered a hallmark of Post Acute Sequelae of COVID-19 (PASC), its basis is poorly understood. The authors here manifest infiltration of peripheral myeloid cells...
nature.com
Rensselaer Polytechnic Institute, cells from 3 mice and 1 human donor showed SARS-CoV-2 spike effects changed with circadian timing. The main shifts were in metabolism and mitochondria, not classic cytokine responses. www.sciencedirect.com/science/arti...
Circadian immunometabolic states impart a temporal response to SARS-CoV-2 spike proteins in mammalian macrophages
Circadian rhythms, driven by 24-h molecular oscillators, or “clocks”, widely tune physiology to the daily rhythms of light and dark to enhance organis…
sciencedirect.com
Imperial College London, 45,864 workers. Unresolved Long COVID was linked to 38% lower odds of remaining in paid work and over 4 times higher odds of changing hours. People with multisystem severe symptoms fared worst. www.sciencedirect.com/science/arti...
sciencedirect.com
What would make you walk away from a Long COVID conference thinking, something is finally changing? What would you want to see, not see, and know before you left?
