At The EQUATOR

@attheequator.bsky.social

Attaining Equity of Access to Research

From open-source platforms to industry-leading software, PBPK modelling offers a tool for every stage of drug development. Davies Otieno guided participants through the strengths and applications of platforms including Simcyp, GastroPlus, PK-Sim, MATLAB/SimBiology and mrgsolve. #PBPK #AtTheEquatorUG

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How can mathematics predict what happens to a drug inside the human body? In an engaging session, MILK PBPK scholar Joshua Kiptoo introduced participants to the core components of Physiologically Based Pharmacokinetic modelling and its growing role in transforming drug development.

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Using lamivudine as a case study, Dr. Ojara showed how combining clinical data with advanced pharmacometric modelling improves predictions of infant drug exposure, reduces uncertainty, and supports safer, evidence-based treatment decisions during breastfeeding. #WCP2026 #PBPK

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His presentation showcased how Non-Compartmental Analysis (NCA), Population Pharmacokinetic (PopPK) modelling, and Physiologically Based Pharmacokinetic (PBPK) modelling each play a complementary role in understanding medicine transfer into breastmilk & estimating infant exposure #WCP2026

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