Phage display identifies macrocyclic peptides that bind the TRF2TRFH domain

Cancer cells are reliant on the DNA-binding protein TRF2 to suppress telomeric instability and thus maintain viability. In this work, we use phage display

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Poly(vinylpyrrolidone) bottlebrush and comb polymers using denatured albumin backbones for potential DNA delivery

We aimed to generate a bottlebrush polymer in which water-soluble poly(vinylpyrrolidone) (PVP) branches were grafted onto denatured bovine serum albumin (B

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The synthesis of sulfonyl fluoride functionalised tetrasubstituted thiophenes using a diversity oriented clicking approach

This work showcases the synthesis of highly functionalised thiophenes bearing a sulfur-fluoride warhead through the diversity-oriented clickable hub 2-subs

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A novel ratiometric fluorescent sensor based on terpyridine derivatives for Zn2+ in aqueous solution

We designed and synthesized a new fluorescent probe G based on 4-bromobenzaldehyde, CH3I and 4-vinylpyridine. Probe G formed a 1 : 1 complex with Zn2+ that

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Advances in transmembrane anion transport by discrete molecular carriers

Life is sustained at the cellular level by maintaining a fine balance of ions across phospholipid membranes. Transmembrane anion transport by small molecul

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Bayesian approaches to assigning the source of an odour detected by an electronic nose

The 18th century cleric Thomas Bayes gave his name to an elegant statement of the probability of an event – in this case identification of an odour – given

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Synthesis and Protein Engineering Applications of Cyclotides

Cyclotides are a group of cysteine-rich peptides derived from plants. Their exceptional stability based on their head-to-tail cyclized backbone and cystine

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Photocycloadditions of benzene derivatives and their systematic application to organic synthesis

In intramolecular reactions of benzene derivatives with alkenes, meta or [2 + 3] photocycloadditions take place in competition with ortho or [2 + 2] additi

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Ru/MgO-catalysed selective aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid

Biomass offers a sustainable alternative source of carbon to existing fossil resources that underpin the global chemical industry – on which we rely for fu

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Blue Betadine assay: a safe, low-cost test for antioxidant activity

Antioxidants, such as those in customarily used plants, are vital to health and nutrition, but testing them often requires expensive or hazardous chemicals

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Peptide thioamides: exploiting a single-atom substitution

This Cornforth Review presents a personal perspective of the Hutton group’s foray into the reactivity of peptide thioamides, highlighting our group’s explo

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Flow-based assembly of nucleic acid-loaded polymer nanoparticles

Treatment of diseases using nucleic acid-based approaches is of increasing importance. However, these drugs need to be delivered in nanoparticles to ensure

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Novel nano-ZnO/alginate films with potential antibacterial properties

The preparation of nano-ZnO/alginate films with strong antibacterial activity that can be used as a new type of wound healing agent in the future is report

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Disclosure of the hydrogen evolution mechanism on [FeFe]-hydrogenases-inspired molecular catalysts – a DFT study

Theoretical calculations on the hydrogen evolution process by [FeFe]-hydrogenases-inspired molecular catalysts were linked with experimental catalytic perf

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A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter

One peptide, two topological stereoisoforms: cysteine-rich peptides are thought to have a defined number of folds depending on the number of cysteine resid

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A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter

One peptide, two topological stereoisoforms: cysteine-rich peptides are thought to have a defined number of folds depending on the number of cysteine resid

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A single stable topological stereoisomer of a two disulfide conotoxin mimetic demonstrates full potency on the human norepinephrine transporter

One peptide, two topological stereoisoforms: cysteine-rich peptides are thought to have a defined number of folds depending on the number of cysteine resid

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Using Indigenous and traditional medicine knowledge in research and development for drug discovery: hypothetical case vignettes

Graphical abstract showing two research and development pathways: one informed by non-codified Indigenous Knowledge and one informed by codified Traditiona

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closo-Borate aryliodonium zwitterions: convenient intermediates for functional closo-borane derivatives and molecular materials

This review summarizes the formation, structure, stability and reactions of aryliodonium zwitterions of closo-borate anions. The zwitterions are formed by

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Centring Wiannamatta (mother place): the story of the environmental persistence of tri-butyl phosphate within a legacy waste site

This paper examines how a chemical from past industrial waste has persisted at a legacy waste site near Sydney. It shows that small amounts remain, but mos

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Heavy metal concentrations in the tissues of kākahi, Echyridella menziesii (Gray, 1843), and water from wadable depths in Lake Tarawera, Aotearoa–New Zealand

This study identified that concentrations of heavy metals vary spatially within Lake Tarawera, with greater concentrations in areas of higher water flow, p

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openGDE/bayadjamara: an open-source 3D-printable gas diffusion electrochemical reactor platform

This paper introduces our development of a customisable 3D-printed platform for electrochemical reactors, including demonstrative data and detailed build i

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Using Indigenous and traditional medicine knowledge in research and development for drug discovery: hypothetical case vignettes

Graphical abstract showing two research and development pathways: one informed by non-codified Indigenous Knowledge and one informed by codified Traditiona

connectsci.au

openGDE/bayadjamara: an open-source 3D-printable gas diffusion electrochemical reactor platform

This paper introduces our development of a customisable 3D-printed platform for electrochemical reactors, including demonstrative data and detailed build i

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Flow-based assembly of nucleic acid-loaded polymer nanoparticles

Treatment of diseases using nucleic acid-based approaches is of increasing importance. However, these drugs need to be delivered in nanoparticles to ensure

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Chemical constituents of lawang root oil

Lawang oil is a traditional medicine that is applied topically to reduce soreness associated with swollen joints. Spectroscopic analysis of commercial root

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Synergistic effects of size and nitrogen doping in modulating the optical and electronic properties of biphenylene quantum dots: a theoretical study

A comprehensive DFT and TDDFT study explores size and nitrogen doping synergistic effects in biphenylene quantum dots (BPQDs). Edge and surface doping indu

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