An excellent piece on our CRATERs paper, now in @science.org 👇 Thanks to editor Priscilla Kelly and Science magazine for highlighting our work! In Other Journals | Science www.science.org/doi/10.1126/...

In Other Journals

Editors’ selections from the current scientific literature

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👇And happy Thanksgiving everyone!

Cell - a Cell Press journal@cp-cell.bsky.social · 9mo ago

The new issue is out 👉 www.cell.com/cell/current On the cover: Ludin et al. identify antigen-rich tumor niches, CRATERs, on the solid tumor surface, which facilitate CD8+ T cell-tumor interactions and tumor killing.

CRATERs on Cover! Thanks @cp-cell.bsky.social for choosing our study for the cover of the Nov 26th issue! A beautiful illustration by @maayanvisuals.bsky.social and @mgarbelli.bsky.social depicting CD8+ T cells descend into CRATERs on a melanoma, where they will engage with the tumor and kill it.

CRATERs have been identified as sites of increased tumor antigen presentation where T cells can recognize and kill tumor cells bit.ly/3J8g42v  @ayaludin.bsky.social

🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social. Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)

That's true! We had to develop quite a bit of new technology to be able to see what we report (big thanks to @asaftal.bsky.social !). Thank you, Yi!

Yi Feng@fengfishlab.bsky.social · 10mo ago

Timely and important👇zebrafish cancer models provide unprecedented mechanistic insights on immune-cancer interaction 👏👏👏 solid work takes years to mature!!!

🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social. Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)

Now online! CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success

CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success

CD8+ T cells preferentially engage tumor cells in pockets termed CRATERs, which are rich with antigen presentation molecules and breach into the tumor mass from the stromal compartment. CRATERs expand and become the major site of tumor killing during immune-stimulatory treatment, and their expansion parallels clinical benefit in patients undergoing immunotherapy.

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