Bach Lab | TUM
@bach-lab.bsky.social
Photocatalysis, Supramolecular Catalysis, Total Synthesis, and C-H Activation (student run account)
We were delighted to welcome Professor Robert J. Phipps from @cam.ac.uk as a speaker in the @crc-325.bsky.social lecture series on "Exploring New Catalysts and Strategies for Enantioselective Photocatalysis." Thank you for your insights and fruitful discussions! #CRC325 #Photocatalysis #Catalysis
Welcome to the newest members of our group! 🎉 Dr. Shiksha Deswal has joined us as a postdoc, while Laura Berner, Sara Zilly, and Stephan Kirschner have started their Master’s theses. We wish you the very best for your projects! 💡🧪 #TUM #Chemistry #Research #Postdoc #WomenInSTEM
We have a freshly minted PhD! Congratulations to Dr. Maximilian Iglhaut! 🎉 We are incredibly proud of you and wish you all the best for your next career step in the Garg lab at UCLA @uclacb.bsky.social We will miss you and look forward to your future successes! 🎓 #TUM #graduation #photochemistry
It was a pleasure having Professor Guangbin Dong @gd5696.bsky.social as a speaker in the CRC 325 lectures series @crc-325.bsky.social. Thank you for your excellent talk on "Simple Looking but Non-Obvious Transformations" and for the engaging discussions! 🙌🌟 #crc325 #TUM
Check out our newest publication on the photochemical deracemization of aza-1-isoindolinones! Out now in @jacs.acspublications.org 🌟Congratulations to Philip and all thecollaborators from the @hauer-lab.bsky.social and @bannwarthlab.bsky.social group💡🧪
Photochemical Deracemization of Aza-1-isoindolinones: Critical Influence of Catalyst Substitution and the Nature of Its Resting State
The photochemical deracemization of aza-1-isoindolinones has been investigated. A chiral para-methoxy-substituted phenyl ketone was discovered that promotes the conversion of racemic 4-aza-1-isoindoli...
doi.org
🎓 Congratulations to our freshly minted PhD, Dr. Johannes Hofer! We’re incredibly proud of you and will truly miss having you around. All the best for your future journey and career! 👏✨ Miau 🐈 #PhDLife #Graduation #photochemistry
Congratulations to our freshly minted PhD Dr. Christoph Buchelt👏 Wishing you all the best for your future 🎓✨ #PhD #graduation
Excited to share our newest ACS Catalysis paper @pubs.acs.org from Benny, jointly from our lab and @cathleenzeymer.bsky.social on the enantiodivergent evolution of a de novo protein for [2+2] photocycloadditions! 💡🙌 #photochemistry #photoenzyme #biocatalysis 💡🙌
Enantiodivergent Evolution of a De Novo Protein for Enzymatic [2 + 2] Photocycloaddition Activity
The design of artificial photoenzymes by incorporating synthetic chromophores into proteins represents a promising strategy to achieve non-natural biocatalytic transformations with high levels of ster...
pubs.acs.org
Our new paper on the dearomatization of aromatic carbonyl compounds by photocycloaddition is out now in Organic Letters @pubs.acs.org Congratulations, Luis, for your excellent work 💡🙌💫 #photochemistry pubs.acs.org/doi/10.1021/...
Dearomatization of Aromatic Carbonyl Compounds by Photocycloaddition Reactions to 1,1-Dimethylallene
The photocycloaddition of 1,1-dimethylallene to various aromatic carbonyl compounds was found to occur exclusively at the benzene core. While the reaction with methyl 2-methoxybenzoate resulted in a mixture of products resulting from ortho, meta, and para photocycloaddition, acetophenone and its 4-substituted derivatives delivered the respective para photocycloaddition products in 50–58% yields. For 2-methoxyacetophenone, an ortho photocycloaddition initiated a reaction cascade, which led to bicyclic products by the incorporation of a nucleophile in 29–74% yields.
pubs.acs.org
We're very proud to announce our newest publications on the photochemical cyclization of tertiary buta-2,3-dienamides to β-lactams! A big thanks to the collaborators from the Kerzig Group (@ckerzig.bsky.social) @angewandtechemie.bsky.social #photochemistry 💡🙌🧑🔬 onlinelibrary.wiley.com/doi/10.1002/...
Photochemical Cyclization of Tertiary Buta‐2,3‐dienamides to β‐Lactams Upon Triplet Energy Transfer
Energy transfer is the key to the successful photocyclization of the title compounds to 3,4-disubstituted 2-azetidinones. If the substituent at the nitrogen atom is primary (R2 = H), trans products a...
onlinelibrary.wiley.com
We're very happy to welcome our new Postdoc Dr. Rachel Cantrell! We wish you best of luck for your research 🌟💡👩🔬 #photochemistry #WomeninSTEM
Check out our newest publication on the photochemical deracemization of chromanes! Amazing work @bikig6.bsky.social Out now in @angewandtechemie.bsky.social 💡🌟 #photochemistry #deracemization doi.org/10.1002/anie...
Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds
Various substituted chromane-2-carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was ...
doi.org
Congratulations to the Bach group (@bach-lab.bsky.social) for this very nice Co-catalyzed asymmetric C-H alkylation, to which we contributed a few DFT calculations: pubs.acs.org/doi/10.1021/...
Enantioselective Intramolecular C–H Alkylation Catalyzed by a Nonsymmetric Chiral Cobalt Porphyrin
Upon catalysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor underwent an enantioselective C–H alkylation at carbon atom C4. Formation of five-, six-, a...
pubs.acs.org
We're very excited to announce our new publication on enantioselective intramolecular C-H Alkylation with Nonsymmetric Chiral Cobalt Porphyrin! Out now in @jacs.acspublications.org 💡🧪https://pubs.acs.org/doi/10.1021/jacs.5c19047
Enantioselective Intramolecular C–H Alkylation Catalyzed by a Nonsymmetric Chiral Cobalt Porphyrin
Upon catalysis (1 mol %) by a chiral cobalt porphyrin, quinazolinones with a tethered diazo alkane precursor underwent an enantioselective C–H alkylation at carbon atom C4. Formation of five-, six-, a...
pubs.acs.org
We kicked off the season with an early Christmas party this year and truly enjoyed the evening together with some of our alumni 🌟 Wishing everyone a smooth December and cozy winter days ahead 🎁🎄 #chemistry #alumni #holidays
Congratulations to our newly minted PhD Dr. Max Stierle! We are very proud of you and we will miss you! 🧪💡🎓 #phd #graduation #photochemistry
We were very happy to have Todd Hyster from Princeton University as a speaker for the CRC325 lecture series yesterday. Thank you for your inspiring talk about photoenzymatic catalysis! 💡🧪 #crc_325 #enzyme #princeton
Another contribution to photochemical deracemization! Check out Max' outstanding work on chiral phosphoric acids, out now in @chemicalscience.rsc.org! 💡🧑🔬🧪 #photochemistry #CPA #deracemization doi.org/10.1039/D5SC...
Photochemical deracemization of 2,3-allenoic acids mediated by a sensitizing chiral phosphoric acid catalyst
Photochemistry opens the possibility to convert a racemic mixture of a chiral compound into a distinct enantiomer in a single operation. Seven chiral phosphoric acids with a pendant thioxanthone chrom...
doi.org
Another recent most read article, from @bach-lab.bsky.social 'Photocatalytic reductive incorporation of carbon dioxide into double bonds' 🔓
Photocatalytic reductive incorporation of carbon dioxide into double bonds
Carbon dioxide (CO2) is a challenging molecule to incorporate into olefins due to its inherent inert properties. Silanes have now been shown to rapidly react selectively with CO2, catalysed by the…
buff.ly
Great news! Check out our latest paper on the co-catalytic photochemical kinetic resolution by dehydrogenation. Amazing work, Chao! 💡🙌🧪 #photochemistry #dehydrogenation #kineticresolution doi.org/10.1021/jacs.5c07524
Kinetic Resolution of Heterocyclic Lactams by a Photocatalytic Cobalt-Catalyzed Dehydrogenation
Chiral heterocyclic lactams have been kinetically resolved in a photochemical process that involves selective hydrogen abstraction by a chiral benzophenone catalyst. Recognition of one enantiomer is ...
doi.org
What an amazing day at the Campus Run 2025! 🏃♀️🏃♂️ So proud of everyone who took part! Huge participation and great energy all around. Special shoutout to Simone for finishing 3rd fastest woman over 11 km! 🔥 Big thanks to our awesome cheer squad 🫶 You really made a difference! 💙💪 #CampusRun #Race #TUM
Amazing work, Johannes! Check out his contribution to the work of the Green Group from @uommib.bsky.social on ennatioselective photoenzymatic C-H insertion of quinolones, out now in @natchem.nature.com! #photochemistry #photoenzyme #enantioselective💡🧬🥳 www.nature.com/articles/s41...
Efficient and selective energy transfer photoenzymes powered by visible light - Nature Chemistry
Recent studies have shown that energy transfer photoenzymes can be engineered to promote stereocontrolled [2 + 2] cycloadditions; however, existing systems rely on ultraviolet light and display limite...
nature.com
First defense of the year: Congratulations to freshly minted Dr. Niklas Pflaum! Excited to have you for a few more months with us #PhD #graduation 🎓👏💡
Excited to share the news: Niklas' paper on enantiopure oxetanes is out now in @jacs.acspublications.org. Great work by all and big thanks to all collaboration partners! 💡👏 #photochemistry #enantioselectivity doi.org/10.1021/jacs...
Oxetane Cleavage Pathways in the Excited State: Photochemical Kinetic Resolution as an Approach to Enantiopure Oxetanes
Chiral spirocyclic oxetanes [2-oxo-spiro(3H-indole-3,2′-oxetanes)] were subjected to irradiation in the presence of a chiral thioxanthone catalyst (5 mol %) at λ = 398 nm. An efficient kinetic resolut...
doi.org
Happy 60th birthday, Thorsten! 🎂🍾🎈 Thank you for being an amazing PI, for all your support and motivation. We hope there will be many more happy occasions to celebrate with you in the future. We wish you all the best for your next 60 years 😇😁 #birthday #celebration #60years
Interested in photochemical activation of carbon dioxide? Check out Mark's work by using sequential silylation/HAT of CO2! Out now in Chem. Commun. by @rsc.org. #photochemistry #carbondioxide 💡🫧 pubs.rsc.org/en/content/a...
Photocatalytic Reductive Incorporation of Carbon Dioxide into Double Bonds
Carbon dioxide (CO2) is a challenging molecule to incorporate into olefins due to its inherent inert properties. Silanes have now been shown to rapidly react selectively with CO2, catalysed by the presence of a caesium base, to form formate salts which can undergo a hydrogen atom transfer (HAT) to give the d
pubs.rsc.org
New paper out now in @angewandtechemie.bsky.social! Congratulations Max on your successful project on photochemically induced Diels-Alder reactions of twisted cycloheptenones. Big thanks also to all collaboration partners! #photochemistry #enantioselective 💡👏 onlinelibrary.wiley.com/doi/10.1002/...
Enantioselective Photochemical Generation of a Short‐Lived, Twisted Cycloheptenone Isomer: Catalytic Formation, Detection, and Consecutive Chemistry
Cyclohept-2-enone-3-carboxylic acid undergoes a photochemical isomerization from its cis- to its trans-form either upon direct irradiation (λ = 366 nm) or in the presence of a triplet sensitizer (λ =...
onlinelibrary.wiley.com
Welcome Veronika to our group! 🙌 Good luck for your Master's thesis on borylations. 👩🔬💫 #WomeninSTEM #catalysis
