Evaluating the Clinical Impact of CYP2C19 and CYP2D6 on Amitriptyline Outcomes in a Real-World Chronic Pain Cohort | Giovanni Ferreira

Pharmacogenomics is often promoted as a way to personalise treatment, but how useful is it for medicines commonly used in chronic pain? In a new preprint, we examined whether variation in the CYP2C19...

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Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

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Human assembloid model of the ascending neural sensory pathway - Nature

A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.

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Twenty years of genome-wide association studies

The first robust association between a genetic variant and disease risk.

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Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease - Nature

After transplantation into the brain of patients with Parkinson’s disease, allogeneic dopaminergic progenitors derived from induced pluripotent stem cells survived, produced dopamine and did not form tumours, therefore suggesting safety and potential clinical benefits for Parkinson’s disease.

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Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature

The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

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How the brain remembers what gave you food poisoning

We've all been there: one bad oyster ruins seafood forever. Now, Princeton neuroscientists have pinpointed how the brain stores memories for these powerful food aversions in mice. The new results reve...

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First map of human brain mitochondria is ‘groundbreaking’ achievement

Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

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Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing

Ageing is a scientifically fascinating and complex biological occurrence characterised by morphological and functional changes due to accumulated molecular and cellular damage impairing tissue and org...

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RPubs - Using Linear Models with the Algal Bloom Data

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Assistant/Associate Professor in Computational Biology - Job Opportunities - University of Cambridge

Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.

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Unit researchers contribute to the Food Foundation Broken Plate 2025 report - MRC Epidemiology Unit

The Broken Plate Report 2025 has found that too many people in the UK do not have the finances to access healthy, quality food. The report also evidences the fact […]

mrc-epid.cam.ac.uk

Funding needed to study potential link between bushfire smoke and dementia Funding needed to study potential link between bushfire smoke and dementia

QIMR Berghofer is appealing for donations from the community to help researchers conduct an Australian-first study into the potential link between bushfire smoke exposure and dementia.

qimrberghofer.edu.au