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Nicholas Ball

@ballnchemist.bsky.social

Synthetic chemist and Associate Professor of Chemistry at Pomona College @pomonacollege. Son of TN, fan of fluorine, Black, and QPOC 🌈. My opinions are my own.

8 Posts476 Follower173 Folgt
Nicholas Ball@ballnchemist.bsky.social · last yr.

SuFEx welcomes new coupling partners - carbon pronucleophiles now in @chemicalscience.rsc.org . Congrats to Ball Lab students Joe Novicku and Matt Teeter and Pfizer colleagues Alistair, Tom, Neil, ans @chrisamende.bsky.social on the great work! #MyFirstChemSci pubs.rsc.org/en/content/a...

Sulfur fluoride exchange with carbon pronucleophiles

Aryl alkyl sulfones are an important class of compounds in drug discovery; thus, new methods toward their synthesis are desirable. A general sulfur fluoride exchange (SuFEx) method to couple aryl sulf...

pubs.rsc.org

Nicholas Ball@ballnchemist.bsky.social · last yr.

With great thanks to NIGMS, the Ball Lab has had our R15 renewed! It took 19 months, but very thankful to the NIH for their support. I am looking forward to training undergraduates with Prof. Ogba @HMC and Dr. am Ende at Pfizer to conduct excellent research in SuFEx!

Nicholas Ball@ballnchemist.bsky.social · last yr.

Check out our new paper with the Stieber Lab @calpolypomona providing evidence that Ni can activate sulfonyl fluorides, resulting in a new binding modality of sulfur dioxide to nickel. Such a privilege to be a part of this work! pubs.acs.org/doi/10.1021/...

Flash Communication: Sulfonyl Fluoride Activation via S–F and C–S Bond Cleavage by a Ni(0) Bis-Bidentate N-Heterocyclic Carbene Complex

This work investigates possible mechanisms and intermediates in the reactivity of p-toluenesulfonyl fluoride with a new bidentate N-heterocyclic carbene (NHC) nickel complex, (MesNHC2oXy)Ni(COD) (Mes ...

pubs.acs.org

Nicholas Ball@ballnchemist.bsky.social · last yr.

Check out the new preprint we have with the Stieber lab featuring Nickel activation of sulfonyl fluorides! The team at @calpolypomona are extraordinary! chemrxiv.org/engage/chemr...

Sulfonyl fluoride activation via S-F and C-S bond cleavage by a Ni(0) bis-bidentate N- heterocyclic carbene complex

This work investigates possible mechanisms and intermediates in the reactivity of p-toluenesulfonyl fluoride with a new bidentate N-heterocyclic carbene (NHC) nickel complex, (MesNHC2oXy)Ni(COD) (Mes ...

chemrxiv.org

Nicholas Ball@ballnchemist.bsky.social · 2y ago

Check out the latest from our lab's @theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange. pubs.acs.org/doi/10.1021/...

Lewis Acid-Catalyzed Sulfur Fluoride Exchange

A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into S–N bond-containing compounds via sulfur fluoride exchange. The reaction successfully employs Ca(NTf2)2 as a catalyst to form sulfonamides, sulfamates, and sulfamides using in situ-generated or commercially available silyl amines in 35–99% yields. Other metal Lewis acids are also demonstrated to be catalysts in SuFEx, forming sulfonamides and sulfamates in yields comparable to those of Ca(NTf2)2.

pubs.acs.org