Intestinal stem cells count to eight divisions to maintain cell ratios

In the fly gut, stem cells keep the balance of cell types by undergoing eight rounds of cell division to form absorptive cells, then one round to form secretory cells.

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Intestinal stem cells count self-renewal divisions to switch multipotency - Nature

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

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Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

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Tertiary lymphoid structures harbour stem-like tumour-specific T cells - Nature

Renal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced...

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Prior therapy defines mutation profiles in childhood cancer at relapse - Nature

Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, hig...

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Rare contagious cancer discovered in wild catfish

Transmissible tumours have been found in only a few types of animal, but there might be many more out there.

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Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma - Nature

Chimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced...

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Modular in vivo antibody–ADC click to reverse drug resistance in tumours - Nature

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant ...

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A high-fat, low-carbohydrate diet can feed intestinal tumours

A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

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Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones - Nature

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketoge...

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Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy - Nature

Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models&...

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Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia - Nature

An ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, cli...

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Aneuploidy selects for the acquisition of driver genes in breast cancer - Nature

Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity ...

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Casdatifan shows durable response linked to HIF-2α biology in kidney cancer - Nature

Monotherapy with the HIF-2α inhibitor casdatifan achieves meaningful, durable responses linked to HIF-2α biology with manageable safety in the treatment of individuals with clear cell renal cell ...

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Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells - Nature

Integrated multi-omic profiling of glioblastoma reveals GPNMB as a shared antigen in tumour cells and the surrounding microenvironment, and GPNMB-targeted chimeric antigen receptor T cells demonstrate...

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Liver fat steers the outcome of advanced colorectal cancer

Individuals with fatty-liver diseases have a heightened risk of aggressive secondary tumours in colorectal cancer.

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Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC - Nature

Liver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen production.

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A prognostic human brain network for diffuse midline glioma - Nature

Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...

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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

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Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

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Ecotypes of triple-negative breast cancer in response to chemotherapy - Nature

Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...

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Non-invasive profiling of the tumour microenvironment with spatial ecotypes - Nature

Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...

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Two decades of PARP inhibitor synthetic lethality in cancer - Nature

The past two decades of PARP inhibitor synthetic lethality in cancer is explored.

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Male sex hormone loss aids brain tumour growth

Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours.

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Androgen loss accelerates brain tumour growth via HPA axis activation - Nature

Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.

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Evolutionary characterization of lung cancer metastasis - Nature

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

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EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk - Nature

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

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Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers - Nature

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...

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A mechanism for adaptive genome regulation in cancer - Nature

In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.

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