Paul Beales

@bealeslab.bsky.social

Professor of Soft Matter & Biophysics. Membranes, vesicles, medical applications, artificial cells. Interdisciplinary science education. Art-science interface.

In the run up to confirmation and clearing, the BBC will be running a series of feature articles that portray universities in a negative light, rubbing salt in the wounds of a sector suffering from underfunding and financial deficits. www.bbc.co.uk/news/article...

Should student mental health responsibility fall to universities?

The number of students reporting mental health concerns is rising. But to what extent should the onus be on universities?

bbc.co.uk

The Softcomp annual meeting is starting in Venice-Mestre. Looking forward to catching up with the community and making new connections. Already had very interesting and fruitful discussions over lunch.

BildBild

"Those travelling to the US need information on what customs and border protection staff are entitled to seize or search, including phone and laptop security; what to do if detained at customs; their rights if arrested; and risks of relocation to prisons within the US or El Salvador."

Research Professional News@resprofnews.bsky.social · last yr.

A safety manual for academics visiting America. Petra Boynton looks at what advice UK universities should give US-bound researchers and students. Trending on our site: www.researchprofessionalnews.com/rr-news-uk-v...

New paper led by the work of Darcey (experiment) and Anna (modelling) looking at how membrane transport and membrane potentials regulate an autocatalytic enzyme reaction confined within vesicles. We find that proton transport can be used to regulate reaction dynamics. doi.org/10.1021/acsn...

Membrane Transport Modulates the pH-Regulated Feedback of an Enzyme Reaction Confined within Lipid Vesicles

Understanding ion transport dynamics in reactive vesicles is pivotal for exploring biological and chemical processes and essential for designing synthetic cells. In this work, we investigate how proton transport and membrane potential regulate pH dynamics in an autocatalytic enzyme reaction within lipid vesicles. Combining experimental and numerical methods, we demonstrate that compartmentalization within lipid membranes accelerates internal reactions, attributed to protection from the external acidic environment. In experiments, we explored how proton movement significantly impacts internal reactions by changing bilayer thickness, adding ion transporters, and varying buffers. Numerical investigations incorporated electrical membrane potential and capacitance into a kinetic model of the process, elucidating the mechanisms that dictate the control of reaction time observed in the experiment, driven by both electrical and chemical potential gradients. These findings establish a framework for controlling pH clock reactions via membrane changes and targeted manipulation of proton movement, which could aid in the design of synthetic cells with precise, controlled functionalities.

doi.org

With all the talk of Elon Musk's fellowship of the Royal Society, there's not enough focus on how he's an FRS in the first place. Is financing companies a “substantial contribution to the improvement of natural knowledge”? He clearly hasn't been the intellectual driver of all these technologies!

Research intensive UK universities would collapse in no time at all if UKRI overhead rates were capped at 15%. Some US universities have considerable endowment funds to fall back on, but I bet many outside the top tier of institutions don't.

Carl T. Bergstrom@carlbergstrom.com · 2y ago

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

Clearly, I'm a leader in my institution, having moved 2 weeks before them! 😆 In reality, I'm well behind the wave of trend-setters and should have done it several months earlier... As should every academic institution. Surprised RP aren't using his formal academic title though... Elon Musk FRS. 😬

Research Professional News@resprofnews.bsky.social · 2y ago

The University of Leeds has become the first Russell Group university to officially announce that it is quitting Elon Musk’s social media site X. It will, however, be alive and well on Bluesky. www.researchprofessionalnews.com/rr-news-uk-u...