@Bernard-S-Lopez.bsky.social
@bernard-s-lopez.bsky.social
Research Director at CNRS. Cochin Institute. Genome Stability instability, DNA repair and recombination, replication stress. Nanomaterials, Clay mineral, silicates
Plot twist: homologous recombination actually promotes the development of cancer! This discussion has been started in the hope that it will be useful, see the link: doi.org/10.1038/s413...
RAD51-mediated homologous recombination is a pro-tumour driver pathway - Oncogene
Oncogene - RAD51-mediated homologous recombination is a pro-tumour driver pathway
doi.org
The LoL-DDR (doi.org/10.1038/s414...) is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner - Cell Death & Differentiation
Cell Death & Differentiation - A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
doi.org
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability. (A new role for the oncogene AKT1: the phosphorylation of MRE11). academic.oup.com/nar/article-...
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1
Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic
academic.oup.com
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
