Psychedelics and women’s mental health: the effects of female sex hormones on psychedelics’ efficacy and tolerability - Molecular Psychiatry

Molecular Psychiatry - Psychedelics and women’s mental health: the effects of female sex hormones on psychedelics’ efficacy and tolerability

doi.org

Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics - Molecular Psychiatry

Molecular Psychiatry - Next-generation precision medicine for mood disorders: reproducible blood biomarkers enable objective diagnostics, subtyping, and targeted therapeutics

nature.com

Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks - Nature Communications

LSD, Psilocybin and 2C-B are different serotonergic psychedelic drugs with slightly different pharmacology. Here, authors show that while they all share the power to reshape neuronal communication acr...

nature.com

Predictive dysfunction: toward a unifying mechanism-based framework for psychiatry - Translational Psychiatry

Translational Psychiatry - Predictive dysfunction: toward a unifying mechanism-based framework for psychiatry

nature.com

Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification - Nature Neuroscience

Researchers discover a transient inhibitory cell type, and reveal that the developing cortex builds inhibitory diversity through three routes—early commitment, gradual diversification and selective el...

nature.com

Single-neuron resolution mapping of dopaminergic connectivity across development, adulthood, and degeneration

Using a novel intersectional genetic strategy for sparse neuronal labeling, Grossouw, Heijmink, et al. reconstruct individual midbrain dopamine neurons throughout development, adulthood, and degenerat...

cell.com

An Update on the Model of Connectivity of the Hippocampal Formation (I): The Perforant Pathway to the Dentate Gyrus

The hippocampus participates in crucial functions such as memory consolidation, spatial processing and emotional regulation that require diverse input from multiple cortical areas that is funneled th...

onlinelibrary.wiley.com

Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

elifesciences.org

Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry

Top down signaling from the cortex to the hypothalamus is critical to link cognitive and emotional processing to homeostasis and motivation. This study investigates signaling from the medial prefronta...

jneurosci.org

Circuit transitions from fear and anxiety to suicidal brain states

Fear, anxiety, and suicidality are often conceptualized along a severity continuum; however, this view fails to capture critical mechanistic differenc…

sciencedirect.com

Cannabinoid neuropharmacology across the lifespan: how aging recalibrates risk and benefit - Neuropsychopharmacology

Neuropsychopharmacology - Cannabinoid neuropharmacology across the lifespan: how aging recalibrates risk and benefit

nature.com

Redirecting

doi.org

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

The hidden logic of emotion

Internal emotion models unify research across species and spark fresh ideas for treating anxiety and trauma

science.org

Redirecting

doi.org

Frontiers | Sex-dependent effects of psychedelics: review of evidence from rodent models

Classic psychedelics, including psilocybin, LSD, DMT, 5-MeO-DMT, mescaline, and phenethylamines such as DOI, exert their core effects through 5-HT2A receptor...

doi.org

Toward a definition of treatment-resistant posttraumatic stress disorder: A systematic review | Journal of Military, Veteran and Family Health

Introduction: Posttraumatic stress disorder (PTSD) is a complex disorder that often persists despite the use of evidence-based treatments. This systematic review aims to synthesize existing definitions of treatment-resistant PTSD (TR-PTSD) and examine ... Lay Summary Posttraumatic stress disorder (PTSD) is a serious mental health condition, and for some individuals, standard treatments such as medication or therapy do not lead to significant improvement. When PTSD remains unresponsive to treatment, it is ...

doi.org

Frontiers | Systems-based psychiatry: insights from psychedelic research on mechanisms of healing

Current psychiatric models, while clinically valuable, remain limited in their ability to account for the complexity, variability, and context dependence of ...

doi.org

doi.org

Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics - Molecular Psychiatry

Molecular Psychiatry - Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics

doi.org

Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health - Molecular Psychiatry

Molecular Psychiatry - Towards a neurobiology of early intervention: the importance of critical periods for preventive psychiatry and youth mental health

nature.com

Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity

Cholecystokinin release from CA3 inputs to CA1 links local excitatory circuitry to hippocampal plasticity and spatial memory.

elifesciences.org

Medial Prefrontal Cortex Innervation of the Basal Forebrain Regulates Behavioral Activation with Prelimbic and Infralimbic Projections Contributing to Distinct Affective Functions in Rats

The medial prefrontal cortex (mPFC) regulates affective and motivational behaviors through its projections to subcortical targets, yet the functional contribution of its innervation of the basal foreb...

jneurosci.org

BPS Publications

Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplastici...

bpspubs.onlinelibrary.wiley.com

sciencedirect.com

CB1R-dependent mitochondrial biogenesis may contribute to the antidepressant effects of esketamine in a chronic variable stress male mouse model

Major depressive disorder (MDD) is a leading cause of disability worldwide, and current antidepressants are limited by delayed onset and incomplete ef…

sciencedirect.com

Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders - Molecular Psychiatry

Molecular Psychiatry - Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders

nature.com

Long- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex - Psychopharmacology

Rationale Psilocybin (PSI) microdosing, defined as a repeated administration of sub-perceptual doses, has gained increasing attention as a potential therapeutic strategy for affective and anxiety diso...

link.springer.com

doi.org

Dorsolateral prefrontal cortex circuitry at the intersection of cognition and disease

Schizophrenia, major depressive disorder (MDD), and Alzheimer’s disease (AD) involve dysfunction of distributed cortical–subcortical networks that support complex cognitive processes and emotion regul...

biologicalpsychiatryjournal.com