Michael Betts
@bettsupenn.bsky.social
Professor of Microbiology at the University of Pennsylvania, expert in human immunology.
Happy to announce publication of our first therapeutic mRNA-LNP paper! In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs | Science Immunology www.science.org/doi/10.1126/...
In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs
Fractalkine-conjugated mRNA-LNPs effectively target cytotoxic effector CD8 T cells for transient in vivo reprogramming.
science.org
link.growkudos.com/1edup3p8u80
Lymph node CD8+ T cells cannot effectively prevent HIV rebound after therapy interruption
We tested whether CD8+ T cells trapped in lymph nodes of SIV infected rhesus macaques during antiretroviral therapy interruption were able to prevent reactivation of viral replication and prevent rebo...
link.growkudos.com
Hello all- we have a new paper on bioarchives, a massive study of lymph node HIV reservoirs at the single cell level. We show that T follicular helper cells are not the major HIV reservoirs during ART. This should prompt reevaluation of curative strategies www.biorxiv.org/content/10.6...
Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART
The multifaceted and long-lived nature of HIV-1 reservoirs has proven to be a formidable obstacle in the development of a therapeutic cure of HIV-1. One of the major dimensions of the HIV-1 reservoir ...
biorxiv.org
Our latest research preprint demonstrating chemokine- based targeting of mRNA-LNPs to cytotoxic CD8 T cells and NK cells. A first in class gene therapy strategy. www.biorxiv.org/content/10.1...
In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP
Selective in vivo reprogramming of cytotoxic effector CD8+ T (Teff) cells holds tremendous promise as a therapeutic tool but has not yet been accomplished. Here, we demonstrate that fractalkine-conjug...
biorxiv.org