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Böckmann Lab

@biomemphys.bsky.social

BioMemPhys – Theoretical & Computational Membrane Biophysics, Professor at Friedrich-Alexander University Erlangen-Nürnberg, Germany – loving biomembranes - immunology - immune domains - plasma membranes - molecular dynamics

53 Posts1021 Follower476 Folgt
Böckmann Lab@biomemphys.bsky.social · 3mo ago

Huge congratulations to Matthias Pöhnl on successfully defending his thesis today🎉 An impressive achievement and the culmination of a tremendous amount of hard work, persistence, and scientific curiosity. Supported by @fau.de and NHR@FAU

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FAU Erlangen-Nbg@fau.de · 6mo ago

Das Video zeigt, wie sich die Hülle des Fetttröpfchens bei Änderung des Umgebungs-pH-Werts nach und nach umorganisiert. Positiv geladene Aminolipide sind blau dargestellt, ungeladene Aminolipide gelb. Mehr erfahren: www.fau.de/2026/01/news... (2/2)

Wie Impfstoff-gefüllte Fetttröpfchen ihre Fracht entlassen

Wenn die Lipidnanopartikel bei Aufnahme in die Zelle in eine saure Umgebung gelangen, organisieren sie ihre Hülle grundlegend um, zeigt eine Studie der FAU.

fau.de

FAU Erlangen-Nbg@fau.de · 6mo ago

Impfstoffe und andere Medikamente werden zum Schutz oft in kleinen Fetttröpfchen verpackt, den sogenannten Lipid-Nanopartikeln. So werden sie von den Zellen aufgenommen und entlassen erst dann ihre Fracht. Um diesen Prozess zu optimieren, haben FAU-Forschende den Vorgang am Computer simuliert. (1/2)

Nachhaltig bewegen@fau-go.bsky.social · 8mo ago

🥘🌍 Cooking for Climate bei der #PublicClimateSchool 🤓😋 Heute in der Mensa Langemarckplatz. Ihr werdet staunen, wer dort gerade für euch kocht! (Was?! Um 6:30 fangen sie an?) Echte Profs aus der Biologie @nat.fau.de, Essensausgabe ab 11:00 mit @biomemphys.bsky.social und @fuhrmannlab.bsky.social

Public Climate School 2025 @ FAU

Die Public Climate School (PCS) ist eine Aktionswoche, in der deutschlandweit vom 24. bis 30. November Bildungseinrichtungen Teile ihres Lehrprogramms so gestalten, dass sie Themen rund um die…

green-office.fau.de

Leonhard Möckl@lmoeckl.bsky.social · 11mo ago

Excited to see this one out in JACS! We analyzed how molecular interactions lead to self-organization of glycolipids down to microseconds and nanometer spatiotemporal scales. Amazing collaboration with the Sandoghdar lab, @biomemphys.bsky.social, and Thisbe Lindhorst! pubs.acs.org/doi/abs/10.1...

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy

Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology...

pubs.acs.org

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Marius Trollmann@m-a-r-i-u-s.bsky.social · 11mo ago

🔔 Excited to share our latest work on the dynamics of synthetic glycolipids in model membranes! 🤩 @biomemphys.bsky.social! Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy | Journal of the American Chemical Society pubs.acs.org/doi/full/10....

Bottom-up Investigation of Spatiotemporal Glycocalyx Dynamics with Interferometric Scattering Microscopy

Over recent decades, the glycocalyx, an extracellular organelle composed of a multitude of glycolipids, glycoproteins, proteoglycans, and glycoRNA, has gained considerable interest in cellular biology. While research in this field has revealed its tremendous importance in ever more aspects of physiological and pathological cellular processes, many of the principles that govern the role of the glycocalyx in these processes on a molecular level are still unknown. In order to unravel the fundamental laws underlying glycocalyx function, new technologies are required that enable the distinction between individual subprocesses within the intricate environment of the glycocalyx. Here, we establish an experimental platform to investigate the dynamics of the glycocalyx at the nanometer and microsecond length and time scales in a bottom-up fashion. We synthesized defined oligosaccharides and installed them on supported lipid bilayers. This way, synthetic glycolipids were assembled to glycocalyx model systems with tunable properties. By investigating these tunable model systems with interferometric scattering (iSCAT) microscopy, we gain access to the required spatiotemporal resolution. We found a strong correlation between the molecular structure of several investigated model glycans and global dynamics of the system. Our findings are corroborated by atomistic molecular dynamics simulations and coarse-grained Brownian dynamics simulations. Our results provide the first direct experimental evidence on the relationship between glycan structure, organization, and dynamics, offering a robust and versatile basis for a quantitative understanding of glycocalyx biology and physics at the molecular level.

pubs.acs.org