Cell therapy successful in treating severe rheumatoid arthritis – BioNews Central

A first-of-its-kind clinical trial found that CAR T-cell therapy substantially reduced disease activity in six patients with severe rheumatoid arthritis, with three requiring no medication by the end of the observation period. ...

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A rogue neuronal signal lies at the root of Alzheimer’s disease – BioNews Central

New findings suggest that abnormal ERBB4 expression—a cell-signaling protein—in excitatory neurons may contribute to several hallmarks of Alzheimer’s disease, including synapse loss, amyloid accumulation, and memory impairment. ...

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Thymus radiation is linked to worse outcomes in patients with non-small cell lung cancer – BioNews Central

Thymus radiation during lung cancer treatment is linked to a higher risk of metastasis and death. ...

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Immune remodeling in supercentenarians: Insights into healthy aging – BioNews Central

Researchers uncover an unusual immune cell that expands in supercentenarians and may help protect against cancer and other age-related diseases. ...

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Oligodendrocyte dysfunction and altered myelin may drive age-related cognitive decline – BioNews Central

Age-related dysfunction in oligodendrocytes, the brain cells that produce myelin, may damage nerve fibres and contribute to cognitive decline. ...

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Experimental synthetic mRNA platform could improve cancer and infectious disease treatments – BioNews Central

An experimental synthetic mRNA platform could help deliver next-generation mRNA therapeutics—including vaccines for infectious diseases, cancer, and autoimmune conditions—more quickly and efficiently than current industry standards. ...

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Mouth and gut microbes could help detect gastrointestinal cancers – BioNews Central

Study finds that analyzing the oral microbiome may detect signals associated with gastrointestinal cancers, potentially enabling less invasive screening. ...

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Gut bacteria convert dietary nitrate and iron into protective molecules – BioNews Central

New research finds that gut bacteria can convert dietary nitrate and iron into protective molecules that may reduce the risk of cardiometabolic diseases. ...

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Newly found ‘immune organ’ inside skull directs brain immunosurveillance – BioNews Central

Researchers have discovered lymph node–like structures in the skull bone marrow of mice that rapidly respond to brain cancer, potentially offering a new approach to treating brain cancer and neurodegenerative diseases. ...

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Why you move — not just how often — could affect dementia risk – BioNews Central

Physically strenuous work may not offer the same brain protection as voluntary leisure-time exercise and may even increase dementia risk. ...

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New stem cell treatment improves vision in patients with aniridia-related keratopathy – BioNews Central

A first-in-human clinical trial reported improved vision after stem cell treatment in patients with aniridia-related keratopathy (ARK), a rare genetic eye condition. ...

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Cannabis use linked to earlier onset of psychosis – BioNews Central

A new meta-analysis shows that cannabis users develop psychosis an average of two-and-a-half years earlier than non-users. ...

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A few minutes of high-intensity exercise may have a greater impact than 90 minutes of moderate running – BioNews Central

Three minutes of all-out sprinting produced far greater and faster blood and fat-cell changes than 90 minutes of moderate exercise, potentially offering stronger benefits for cardiometabolic health. ...

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Drug that targets an inflammatory enzyme could help prevent lung cancer – BioNews Central

Researchers found that blocking the inflammation-related enzyme caspase-1 with a small-molecule drug reduced lung tumor development in mice, suggesting a possible strategy to prevent some lung cancers. ...

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Coffee consumption linked to metabolic health and sex hormones – BioNews Central

Finnish study found that habitual coffee consumption was associated with lower total and visceral fat, greater skeletal muscle mass, healthier metabolic markers, and sex-specific hormone patterns in middle-aged adults. ...

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A simple, low-cost blood test on a chip diagnoses lung cancer without DNA sequencing – BioNews Central

A low-cost blood test on a chip detects lung cancer with over 90 percent accuracy by identifying the tumor's biological fingerprint, offering a potential complement to CT scans for monitoring treatment response. ...

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Ultra-processed foods linked to significantly increased prostate cancer risk – BioNews Central

New research shows that men who consume more ultra-processed foods have a higher risk of prostate cancer, which is the most common cancer and second leading cause of cancer death among men in the U.S. ...

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Pre-cancerous link uncovered between air pollution exposure and lung cancer risk – BioNews Central

A recent study identified measurable molecular changes in blood linked to air pollution exposure that appear years before lung cancer diagnosis, offering potential insights for future cancer research, detection, and prevention. ...

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D-serine promotes tumor growth in gastric cancer – BioNews Central

D-serine, a non-standard amino acid involved in cellular signaling, suppresses cytotoxic T-cell activity in gastric cancer tumors and may contribute to resistance against immune checkpoint inhibitors. ...

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Why the body's inflammatory alarm misfires in hereditary autoinflammatory disease – BioNews Central

Two studies reveal that certain mutations enhance the interaction between a regulatory protein and its partner, causing the immune system to overreact and leading to the hereditary autoinflammatory disease familial Mediterranean fever. ...

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Alzheimer’s-implicated tau protein disrupts mitochondria in nerve cells – BioNews Central

Scientists have shown that abnormal tau proteins, altered by enzymatic changes, infiltrate mitochondria in nerve cells, disrupting energy production and triggering a harmful cycle linked to Alzheimer's and other neurodegenerative diseases. ...

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Obesity drug tirzepatide significantly reduces the risk of infections and serious cardiovascular events – BioNews Central

Tirzepatide, a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes and obesity, can reduce the risk of heart attacks and hospitalizations due to infections by about one-third compared to conventional diabetes treatments. ..

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How good bacteria from fecal transplants reduce peanut allergies – BioNews Central

A small clinical trial showed that some participants with peanut allergies had increased tolerance months after receiving a fecal transplant from healthy donors without food allergies, suggesting microbiome-based therapy may improve food allergy trea

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Immune therapy for Alzheimer's disease takes a step forward – BioNews Central

Phase 1 trial reports positive results for a brain-protective immunotherapy in early Alzheimer's disease. ...

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Common microplastic may increase risk of fatty liver disease – BioNews Central

Researchers have found that polyethylene microplastics may contribute to fatty liver disease and exacerbate its effects when combined with an unhealthy diet. ...

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Immune cells in human lung tissue may drive the development of autoimmune disease – BioNews Central

A comprehensive study analyzing over 1.1 million lung tissue-resident immune cells reveals insights into how their dysfunction may contribute to lung inflammation and autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. ...

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Cell therapy slows muscle decline in young people with Duchenne muscular dystrophy – BioNews Central

A phase 3 clinical trial found that the cell therapy deramiocel may slow muscle weakening and heart damage in boys and young men with advanced Duchenne muscular dystrophy. ...

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Combination of targeted therapies could help overcome treatment resistance in advanced prostate cancer – BioNews Central

New research has identified a strategy to make antibody-drug conjugates more effective against metastatic castration-resistant prostate cancer, potentially overcoming treatment resistance. ...

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Protein restriction: Reducing protein intake could promote healthy aging – BioNews Central

A review of more than 350 studies suggests that protein restriction may promote healthy aging by improving metabolism, reducing cellular damage, and preserving cell function. ...

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Boosting potassium intake: A new strategy for controlling hypertension – BioNews Central

A new report suggests that effectively managing hypertension requires a combined strategy of increasing potassium intake while reducing sodium, prompting a shift in public health recommendations. ...

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