Structural basis for monobody OP-4 binding to open-form adenylate kinase https://www.biorxiv.org/content/10.64898/2026.08.04.742914v1

Waltz, AlphaFold and ESMfold Predictions on a Human Prion Protein Tiled Peptide Library Highlight a C-Terminal Region with Strong Conformational Sensitivity https://www.biorxiv.org/content/10.64898/2026.07.31.742043v1

Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle https://www.biorxiv.org/content/10.64898/2026.08.03.742530v1

A Poly(rC)-Binding Protein Mediates Iron Delivery to Ferritin in Anopheles stephensi https://www.biorxiv.org/content/10.64898/2026.08.04.742707v1

A latent hydrazone switch turns SP2509 into an optical timer of cell fate https://www.biorxiv.org/content/10.64898/2026.08.04.742687v1

Differential induction of 14-3-3 paralogs expression during early and late adipogenesis https://www.biorxiv.org/content/10.64898/2026.08.03.742103v1

Calibrated ADAMTS13 inhibition prevents cardiovascular shear coagulopathy https://www.biorxiv.org/content/10.64898/2026.08.03.742456v1

Discovery of a Cell-Permeable Gi-Signaling Inhibitor https://www.biorxiv.org/content/10.64898/2026.08.02.742274v1

Microtubule Lattice Spacing Governs MAP-Motor Regulation https://www.biorxiv.org/content/10.64898/2026.08.03.742653v1

Structural dynamics underlying agonist activation of a GLP-1R-Gs precoupled complex https://www.biorxiv.org/content/10.64898/2026.08.03.742488v1

Humanized Anti-PD-1 Antibodies Generated Using The Conditional Kernel-Elastic Autoencoder https://www.biorxiv.org/content/10.64898/2026.08.03.742579v1

Improved cross-presentation enabled by fusion-dependent mini-proteins that efficiently reach the dendritic cell cytosol https://www.biorxiv.org/content/10.64898/2026.08.01.742242v1

An architectural switch in the evolution of the γ-tubulin ring complex https://www.biorxiv.org/content/10.64898/2026.08.03.742184v1

Combining Machine Learning and Directed Evolution for Optimization of a Monooxygenase https://www.biorxiv.org/content/10.64898/2026.07.31.742090v1

The structure of the Salmonella phage epsilon15 tailspike reveals multiple O-antigen binding sites and a protruding esterase domain https://www.biorxiv.org/content/10.64898/2026.07.31.742079v1

N-Terminal Alkylation of Proteins with Triazole-4-carbaldehyde for Targeted Liposome Engineering https://www.biorxiv.org/content/10.64898/2026.07.31.742023v1

Compartmentalized oxygen generation from hydrogen peroxide enables anaerobic oxidative phosphorylation and confers a fitness advantage https://www.biorxiv.org/content/10.64898/2026.08.01.742219v1

FAF1 cofactor enhances UFD1/NPL4-p97 unfolding efficiency across ubiquitin chain lengths independent of SUMO2 https://www.biorxiv.org/content/10.64898/2026.07.31.742138v1

Human PHOSPHO2 exhibits Mg2+-dependent phospholipid phosphatase activity https://www.biorxiv.org/content/10.64898/2026.07.31.742009v1

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mapping https://www.biorxiv.org/content/10.64898/2026.08.01.742232v1

Sequence-Dependent DNA Base Selection Fidelity: A Kinetics-based Model and its validation https://www.biorxiv.org/content/10.64898/2026.07.30.741821v1

Electrostatic Complementarity at the ClpX Substrate-EntryChannel Governs ATP-Driven Protein Unfolding https://www.biorxiv.org/content/10.64898/2026.07.31.739446v1

Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization https://www.biorxiv.org/content/10.64898/2026.07.31.742112v1

Enhancing Recombinant Vector Assembly Efficiency: A Novel Methodological Approach https://www.biorxiv.org/content/10.64898/2026.07.30.741931v1

A modular platform for scalable recombinant production of highly toxic bacterial proteins https://www.biorxiv.org/content/10.64898/2026.07.31.742022v1

Discovery of a regulatory node that coordinates cell envelope assembly in mycobacteria https://www.biorxiv.org/content/10.64898/2026.07.31.741936v1

The HSP-90 co-chaperone CDC-37 regulates oomycete immunity in C. elegans through a membrane-associated pseudokinase https://www.biorxiv.org/content/10.64898/2026.07.31.741986v1

Errors in peptide synthesis are a source of discrepancies in Aβ42 studies https://www.biorxiv.org/content/10.64898/2026.07.30.741826v1

Nitrogen metabolic map of Escherichia coli mediated by multi-functional aminotransferases https://www.biorxiv.org/content/10.64898/2026.07.30.740019v1

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions https://www.biorxiv.org/content/10.64898/2026.07.30.741859v1