Hypoxia induces cytotoxicity and suppresses cytokine production by CD8⁺ T cells in cutaneous leishmaniasis. https://www.biorxiv.org/content/10.64898/2026.07.30.741849v1

Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization https://www.biorxiv.org/content/10.64898/2026.07.30.741516v1

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework https://www.biorxiv.org/content/10.64898/2026.07.30.741432v1

Tfh dysfunction underlies poor responses to HBV vaccination https://www.biorxiv.org/content/10.64898/2026.07.30.741822v1

HER2 mutation-derived neoantigens in NSCLC as actionable targets for TCR therapy https://www.biorxiv.org/content/10.64898/2026.07.30.741830v1

Direct measurement and reconstruction of intact polyclonal IgG repertoires to preserve molecular and functional connectivity https://www.biorxiv.org/content/10.64898/2026.07.30.741668v1

Epithelial-Intrinsic Alterations and Maladaptation to Luminal Metabolites Underlie Persistent Crohn's Disease Pathogenesis https://www.biorxiv.org/content/10.64898/2026.07.29.741535v1

Antibody feedback limits specific B-cell entry and alters germinal center repertoires by antibody-antigen complexes https://www.biorxiv.org/content/10.64898/2026.07.29.741558v1

Non-canonical Oncostatin M Signaling Provides Protection during Respiratory Viral and Bacterial infections https://www.biorxiv.org/content/10.64898/2026.07.30.741615v1

2B4 co-engagement promotes serial degranulation and killing by human NK cells https://www.biorxiv.org/content/10.64898/2026.07.31.741999v1

IL1 blockade attenuates E. coli induced intrauterine inflammation and preterm labor in Rhesus macaques https://www.biorxiv.org/content/10.64898/2026.07.30.741586v1

Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma https://www.biorxiv.org/content/10.64898/2026.07.30.741694v1

Comprehensive transcriptomic profiling uncovers an inflammatory maturation program conserved in human and mouse dendritic cells https://www.biorxiv.org/content/10.64898/2026.07.30.741848v1

Determinants in gammaretroviral Env dictate the production of neutralizing antibodies https://www.biorxiv.org/content/10.64898/2026.07.30.741819v1

CX3CR1 And MHCII Define Distinct Synovial Macrophage Populations With Conserved Inflammatory Response Across Mouse Models Of Rheumatoid Arthritis. https://www.biorxiv.org/content/10.64898/2026.07.30.741914v1

PSMε controls skin commensal CD8+ T cell activation https://www.biorxiv.org/content/10.64898/2026.07.30.741773v1

Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumor https://www.biorxiv.org/content/10.64898/2026.07.30.741721v1

Spatial remodeling of the thymic stroma with age disrupts niches for T cell selection and tolerance https://www.biorxiv.org/content/10.64898/2026.07.29.741472v1

Single-dose Efficacy of a Next-Generation Mpox Vaccine Harnessing an Immunomodulatory Peptide https://www.biorxiv.org/content/10.64898/2026.07.31.742137v1

The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome https://www.biorxiv.org/content/10.64898/2026.07.29.741502v1

SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes https://www.biorxiv.org/content/10.64898/2026.07.29.741363v1

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy https://www.biorxiv.org/content/10.64898/2026.07.28.741328v1

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy https://www.biorxiv.org/content/10.64898/2026.07.28.741325v1

FITdb, an Integrated Functional Immunogenomics and Transcriptomics Database https://www.biorxiv.org/content/10.64898/2026.07.28.741304v1

Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation https://www.biorxiv.org/content/10.64898/2026.07.28.741182v1

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults https://www.biorxiv.org/content/10.64898/2026.07.28.741158v1

Copper chelation reprograms the tumour microenvironment to enhance immune checkpoint blockade therapy in preclinical mesothelioma https://www.biorxiv.org/content/10.64898/2026.07.28.740857v1

Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis https://www.biorxiv.org/content/10.64898/2026.07.28.740434v1

Modular counterplays shape condensation and signaling of chimeric antigen receptor https://www.biorxiv.org/content/10.64898/2026.07.27.741008v1

Immunometabolic Reprogramming by Thyroid-Stimulating Antibodies Drives Orbital Adipogenesis via Histone Lactylation in Thyroid Eye Disease https://www.biorxiv.org/content/10.64898/2026.07.27.741014v1