Biosciences Area at Berkeley Lab

@biosci.lbl.gov

Official account of the Biosciences Area of @BerkeleyLab Solving challenges in energy, environment, health, and biomanufacturing. Re-post ≠ Endorsement

We are excited to see so many familiar faces among the recipients of the @jgi.doe.gov - @molecularfoundry.lbl.gov Critical Minerals & Materials call. We are looking forward to writing about all of your great discoveries! @berkeleylab.lbl.gov

Joint Genome Institute@jgi.doe.gov · 4w ago

Congrats to the 20 recipients of our first Critical Minerals & Materials call, in partnership with @molecularfoundry.lbl.gov! These projects integrate genomics with nanoscale science, aimed at developing transformative bio-based technologies involving critical minerals and materials.

Today we wrap up our retiree celebration by wishing Bill Jagust all the best as he embarks on a new chapter after 39 years on #TeamBioSci. He redefined the PET brain imaging program using new tracers to study aging and dementia and will continue as a professor at UC Berkeley. Congratulations, Bill!

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Hi, Jack here! I recently met #BioEGSB’s Peter Andeer for a tour of the EcoBOT self-driving lab. The latest in a line of evolving plant–microbe 🌱🦠 research tech developed at Berkeley Lab, EcoBOT autonomously manages small ecosystems, EcoFABs, that control growth conditions to the microbial level 🧫.

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Built by a team of Berkeley Lab biologists, mathematicians, and engineers, EcoBOT is a self-driving lab that uses advanced computer vision to track plant growth with unprecedented precision. It then applies algorithms to analyze that data and autonomously design and perform follow-up experiments.

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Hi all, Jack here! I recently toured Theia, the powerful custom cryo-EM project led by #BioMBIB scientist Holger Müller. Typical cryo-EMs sacrifice resolution for contrast; Theia uses a laser phase plate to increase contrast while maintaining a higher resolution thanks to its custom configuration.

Two people wearing protective glasses stand next to each other, smiling in front of a tall, complex lab instrument, a cryogenic electron microscope, with many cables and large metal parts.Cryogenic electron microscope interior with the tall microscope column, liquid nitrogen chamber, and numerous bundled cables and control modules. Text boxes on the image say, "Cryo-EMs start with an electron beam that passes through the specimen and into an objective lens. Theia uniquely has an abberation corrector and the laser phase plate." and "The liquid nitrogen freezes samples to about -190°C"A researcher points towards an array of mirrors inside a cryogenic electron microscope cabinet while looking towards someone asking a question. The array surrounds the microscope body, cables and control modules are present in the background.Lab laser optics with steel chamber holding a phase plate. In the background are cables, and an array of mirrors ends into an attached smaller chamber. Text boxes on the image say, "Here is where the laser enters to be focused by a pair of mirrors, building up the intensity to be the brightest continuous laser focus ever." And, "This chamber contains the laser phase plate."

Hi everyone, my name is Jack. I'm a SULI summer intern at Berkeley Lab. Over the next several weeks I’ll be creating posts sharing my experiences learning about cool research projects across the Biosciences Area. I hope you enjoy this series as I much as I enjoy making it!

Person with dark shoulder-length hair wearing a dark long-sleeve t-shirt and jeans stands near some large rocks in front of the facade of a building with a large number 92.

Congratulations to @jbei.lbl.gov's  Corinne Scown on being named one of the 2026 Top Agri-food Pioneers by the World Food Prize Foundation! Scown's work focuses on modeling the economic and environmental impacts of advanced pathways to bio-based fuels and products. Link to read more in comments. 👇

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Structural biology + AI-assisted computer modeling + Directed evolution = A faster path to protein design. By manipulating the “promiscuity” of a designed protein, a team including #BioMBIB faculty scientist James Fraser created two novel proteins with specialized functions. Link in comments. 👇

Colorful graphic with a photo of a researcher and a quote about how observing promiscuous protein binding enabled the creation of an enzyme 10x more active than previous designs.

Quantum tech is growing, but the industry faces a critical shortage of trained scientists and engineers. Berkeley Lab’s A-LIFT Office and Sandia National Laboratories are bridging this gap through the QCaMP program!  Read more about our impact and how to get involved: go.lbl.gov/QCaMP

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A pair of recent studies involving scientists from #BioBSE shed new light on the potential dangers of thirdhand smoke—not just for cancer risk, but for brain health as well. They provide compelling evidence that environmental exposures interact with genetic variation to shape health outcomes.

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