Blood Journals Portfolio

@bloodjournals.hematology.org

Portfolio of peer-reviewed journals from ASH including Blood, Blood Advances, Blood Global Hematology, Blood ICT, Blood Neoplasia, Blood RCI, and Blood VTH https://linktr.ee/bloodjournalsportfolio

New in Blood @bloodjournals.hematology.org lenalidomide (maintenance tx in myeloma) raises B-ALL risk. We show WHY in a subset of cases IDH2 R140Q clonal hematopoiesis + lenalidomide-driven IKAROS loss cooperate to arrest B-cell dev., seeding a distinct leukemia subtype. 🧵 doi.org/10.1182/bloo...

IDH2 clonal hematopoiesis and IKAROS loss cooperate in a B-ALL subtype after lenalidomide therapy for multiple myeloma

Key PointsIDH2 R140Q mutations define a distinct B-ALL subtype that is highly enriched in LenB-ALL.IDH2mt LenB-ALL emerges from IDH2-mutant clonal hematopo

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