Said a final goodbye to my bench at the MPI for Terrestrial Microbiology today. What a feeling @mpimicrobiomarburg.bsky.social
Elisabeth Bobkova
@bobez.bsky.social
PostDoc at Erb Lab, science policy enthusiast, scientific illustrator, metalhead. Yay to using ML, physics and molecular biology to engineer new synbio systems
Very happy to share my first preprint from my PhD 🎉 doi.org/10.64898/202... We develop an αHL-based framework to engineer and quantify selective diffusion across synthetic membranes using controlled nanopore chemistry. 1/7
doi.org
Really enjoyed the 77th #MosbacherKolloquium ! Thanks to the organizers @gbmev.bsky.social for putting together such an amazing program and for giving me the chance to present my poster. To quote André Nadler: Membranes are great, science is great, and let's continue making discoveries! ;)
Just realized, that I have never posted my artwork on bluesky! So here are some of my favorite pieces I got to create during my PhD for different projects from @mpimicrobiomarburg.bsky.social What a journey it has been :)
🚨 Fully funded PhD positions in #microbiology! Join IMPRS Principles of Microbial Life in Marburg,Germany 🌱 Interdisciplinary research 🧬 World-class mentoring 🧪 State-of-the-art research infrastructure 🗓️ Apply until Jan 31, 2026 🔗 imprs-marburg.mpg.de/3197/JOIN-US #PhDposition #WomenInSTEM
Very excited to finally share my PhD paper, about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas. Huge thanks to the whole team! www.nature.com/articles/s41...
A modular high-throughput approach for advancing synthetic biology in the chloroplast of Chlamydomonas - Nature Plants
This study reports a modular-cloning-based platform for high-throughput chloroplast engineering in Chlamydomonas reinhardtii that allows large-scale characterization of genetic parts and prototyping o...
nature.com
Turbo platform for plant research 🚀🪴 Extreme weather events due to #climatechange reduce crop yields. @reneinckemann.bsky.social & team led by Tobias Erb @synmikro.bsky.social has now developed a microalgae platform for fast and efficient tests of chloroplast gene variants s.gwdg.de/hznfNe
With this, the last bit of my PhD at @embl.org is finally out! We developed salad (sparse all-atom denoising), a family of blazing fast protein structure diffusion models. Paper: nature.com/articles/s42256-… Code: github.com/mjendrusch/salad Data: zenodo.org/records/14711580 1/🧵
‘Salad’ – a new AI model from EMBL scientists – offers major improvements in synthetic protein design. Salad is significantly faster than comparable methods, and designing proteins that don't exist in nature can have applications in many scientific fields. www.nature.com/articles/s42...
Just submitted my PhD thesis. Feeling kinda empty now...
www.biorxiv.org/content/10.1...
Modular Engineering of Thermo-Responsive Allosteric Proteins
Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membra...
biorxiv.org
Excited to share a main project from my PhD, out now in @naturecomms.bsky.social! 📝 We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱 nature.com/articles/s41... Take a look! Thread below... 🧵
Thrilled to have been part of the 76th Mosbacher Kolloquium! Huge thanks to @gbmev.bsky.social for organizing such an engaging conference! @anastasiagtz.bsky.so and I were excited to share our insights on differential transport across membranes, and we're truly honored to receive the poster award!
Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! 🔥 Read below to see how we developed the sensors and what they are good for 🥳. www.nature.com/articles/s41...
Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection - Nature Communications
Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for ...
nature.com
Super excited to see my main PhD project finally out in @naturemicrobiol.bsky.social www.nature.com/articles/s41.... We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.
One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle - Nature Microbiology
An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.
nature.com
New protein ML preprint from my PhD project. We describe salad (sparse all-atom denoising), a family of efficient protein structure diffusion models and show that it works well on a bunch of protein design task previously described in the literature. Preprint: www.biorxiv.org/content/10.1... (1/N)