Melissa Bowerman

@bowermanlab.bsky.social

Professor of Neuromuscular & Skeletal Disorders, Keele University. I research pathologies and new treatments in rare neuromuscular & skeletal disorders. www.thebowermanlab.com

A huge congrats to our member Ali Aries for her NIHR Senior Clinical and Practitioner Research Award! This will support her work leading a Roundtable on somatosensation post-stroke for the ISRRA and to develop a Patient and Lived Experience Advisory Team (PLEAT) in The Royal Wolverhampton NHS Trust!

📖 45 of 2025 (10/10): Parable of the Talents by Octavia E. Butler. What a sequel! The story takes an unexpected turn mid-way through. I found it very disturbing that although first published in 1998, its storyline is not a far stretch from what is happening in the USA at the moment. #Booksky

Book cover of Parable of the Talents by Octavia E. Butler showing a red bird

Excited to share Emma Sutton's recently published Ph.D. research! By using cells, worms and mice, we report that mifepristone, a glucocorticoid receptor anatagonist, alone and in combination with an approved SMN-dependent therapy, has the potential to improve SMA disease pathology. rdcu.be/eQpXG

Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice

Scientific Reports - Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice

rdcu.be

📖 44 of 2025 (10/10): Parable of the Sower by Octavia E Butler. A dystopian novel that is not too far from current world events. Beautifully written with an array of characters that display the best and worse of what humanity has to offer. Can’t wait to read the sequel! #Booksky

Book cover of Parable of the Sower by Octavia E Butler showing a black woman in a red dress.

📖 43 of 2025 (10/10): Patriot by Alexei Navalny. More than a memoir: a powerful account of an individual that fought for a free, peaceful, happy and non-corrupt country. Knowing he dies makes it a difficult. Knowing that corruptions openly persists worldwide makes it even more difficult… #Booksky

Book cover of Patriot by Alexei Navalny showing his face.

📖 41 of 2025 (10/10): Normal People by Sally Rooney. This book left me with a ball of mixed intense emotions in the pit of my stomach. And I had to sit with them for a while because I was not ready to say goodbye to Marianne & Connell just yet… #Booksky

Book cover of Normal People by Sally Rooney showing two people cuddling in a can of sardines.

📖 40 of 2025 (8/10): This is Big by Marisa Meltzer. Part biography of the founder of Weight Watchers, part reflection on the author’s relationship with her body weight, it forces you to reflect on a society that too often associates how you look to your worth. #Bluesky

Book cover of This is Big by Marisa Meltzer showing a picture of the founder of Weight Watchers.

Congrats to Ian Holt, a Research Associate in our member Heidi Fuller's group, who won first prize at the Neuromuscular Study Group meeting in Stresa (Italy) for his poster on Characterising PMP22 proximal partners in a Schwann cell model of CMT1A. Well done!

Academic research poster

Our members Sharon Owen & Heidi Fuller were at the Neuromuscular Study Group meeting in Stresa (Italy) last week where Sharon delivered an excellent flash talk presentation on using omics to identify severity-specific differences in spinal muscular atrophy!

Research meeting attendees facing speaker Sharon Owen at the podium and title presentation slide.Research meeting attendees facing speaker Sharon Owen at the podium and introduction slide on spinal muscular atrophy.

This weekend I had the honour of attending the SMA UK's Big Weekend: Forty & Forward to update families on current pre-clinical research priorities in SMA. Clinical trials, exercise, newborn screening, access to education, sex & relationships were also discussed, showing there is still a lot to do!

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📖 39 of 2025 (8/10): Poor by Katriona O’Sullivan. A raw and honest account of a very difficult childhood and how our societal structures and behaviours make it difficult for kids that are born randomly in such circumstances don’t get afforded the same opportunities as others. #Booksky

Book cover of Poor by Katriona O’Sullivan showing a young female child climbing up a wall.

A huge congratulations to Katie, who has successfully passed her MPhil! Her research was aimed at understanding the role of authophagy in SMA and its potential as a therapeutic target. It was a real joy having her join our lab and we already miss her!

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