Timmers et al. examined brain metabolism in myoclonus-dystonia patients with and without SGCE mutations using 18-fluorodeoxyglucose-PET. Findings revealed altered metabolic activity in motor & sensory brain regions, with symptom severity linked to specific areas. 👉 doi.org/10.1093/brai...

Whitmarsh et al. report that deeper non-rapid eye movement sleep increases interictal epileptiform discharge rates, amplitudes, and neuronal firing rate modulation. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Krieger et al. reported longitudinal changes in two MRI biomarkers of early multiple sclerosis: choroid plexus volume increased, while lesional tissue integrity (T1w/FLAIR ratio) decreased, and both were associated. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

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D’Amelio et al. used a mouse model in which herpes simplex virus type-1 reactivations drive the development of Alzheimer’s disease–like phenotype. Mice with mild cognitive impairment showed network hyperconnectivity correlating with motor deficits. Read it at 👉 doi.org/10.1093/brai...

Kalyani et al. report that 7 Tesla functional MRI reveals altered sensorimotor functional connectivity patterns in patients with amyotrophic lateral sclerosis. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Owashi et al. report that craniospinal compliance measured under physiological and infusion conditions differs significantly but remains moderately correlated. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Liu et al. report that intracranial atherosclerosis (ICAS) severity is independently associated with cognitive impairment, whereas plasma biomarkers of neurodegeneration and neuroinflammation show limited explanatory value. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Toyofuku et al. investigated cortical morphology in adolescents with congenital heart disease. Surface area & gyrification were widely altered and strongly associated with cognitive function, whereas cortical thickness showed minimal changes & weak functional associations. 👉 doi.org/10.1093/brai...

Che et al. demonstrated that combining brain computed tomography with synthetic magnetic resonance imaging generated by a deep learning model significantly improved the prediction of traumatic brain injury outcomes, compared to computed tomography alone. 👉 doi.org/10.1093/brai... #neuroscience

Häuselmann et al. report that chronic primary pain patients show altered anterior insula-based brain-state dynamics. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Lin et al. found that isolated dystonia patients show unstable cerebellar, motor and visual cortex activity with increased functional connectivity variability. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Castelhano et al. report that inhibitory neuromodulation over the parietal cortex in stroke patients led to increased homogeneity of GABA and receptor binding levels, along with their augmented positive association. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Kandasamy et al. show that heartbeat-evoked potential (HEP) changes predict the semiology of functional seizures (FSs). An increased and reduced HEP precedes non-motile and motile FSs, respectively. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Hilger et al. found that preserved structural network topology after hypoxic-ischaemic brain injury was associated with recovery of consciousness, whereas reduced network efficiency and hub disruption predicted poorer outcomes. 👉 doi.org/10.1093/brai... #neuroscience

Meet Dr Ivan Kirov, Associate Professor of Radiology and Neurology at New York University (NYU) 👋 His research focuses on the application of magnetic resonance imaging and spectroscopy to neurological disorders, such as Traumatic Brain Injury/Concussion, Multiple Sclerosis and Alzheimer's Disease.

Denève et al. report that detailed language testing distinguishes behavioural frontotemporal degeneration from AD and PPD, highlighting the clinical value of multi-level language assessment. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Ho, Adrie-Afriyie et al. investigate the therapeutic potential of muscle-specific kinase antibody treatment in AGRN and COLQ genetic subtypes of congenital myasthenic syndromes, a rare neuromuscular disease. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Liu et al. report that focal impaired consciousness seizures ≥3 min predict drug-resistant epilepsy, with a model incorporating seizure duration, frontal origin, aetiology, seizure types, and subclinical seizures identifying high-risk patients. Read it at 👉 doi.org/10.1093/brai... #neuroscience

Hseuh et al. developed a machine learning–based quantification platform for intraepidermal nerve fibres on skin biopsies to diagnose small-fibre neuropathy in diabetes. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Liu et al. found that lesions causing post-stroke cognitive impairment map to a common network, with left thalamus–dorsomedial prefrontal cortex connectivity linked to cognitive decline. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Kannan et al. report that the pharmacological inhibition of the c-Jun-NH2 terminal kinase pathway using three drug compounds with distinct chemical scaffolds ameliorates spinal muscular atrophy disease in mice without altering survival motor neuron protein levels. 👉 doi.org/10.1093/brai...

Liu et al. report that patients with migraine show accelerated brain ageing compared with healthy individuals. Regionally, the prefrontal, frontal, cingulate, parietal, temporal and limbic areas are involved. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

In this review, Pesämaa et al. collect and present evidence of ferroptosis-related pathways in activated microglia. They compile an expanded list of ferroptosis-relevant proteins and compare it with reported microglial activation signatures. Read it at 👉 doi.org/10.1093/brai... #neuroscience

Sulkava et al. report association of insomnia symptoms and their genetic liability with incident Parkinson's disease in a Finnish population cohort with a mean follow-up time of 25 years. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Struck et al. applied individualized Z-maps to MRI in 62 juvenile myoclonic epilepsy patients versus 41 controls, revealing motor thalamic/subcortical reductions and three imaging endophenotypes. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Zhang et al. report that language therapy in patients with post-stroke aphasia enhances coupling between global blood oxygen level–dependent brain activity and cerebrospinal fluid dynamics, particularly within language-related brain systems. Read it at 👉 doi.org/10.1093/brai... #neuroscience

Agarwal et al. report that brain connectivity within olfactory networks, together with anxiety, predicts vulnerability to alcohol dependence. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Torraco et al. report that variants in NDUFAF6 cause a heterogeneous mitochondrial disease characterized primarily by bilateral striatal necrosis and reduced complex I activity. Read it at 👉 doi.org/10.1093/brai... #neuroscience #braincommunications

Congratulations to our former Editor-in-Chief, Prof Tara Spires-Jones, the newly elected President-Elect of Federation of European Neuroscience Societies (FENS)! 👏🧠 #neuroscience #braincommunications #FENS