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Statistical Consistency in Artificial Intelligence-Assisted Computations: A Comparison of SPSS 31.0 and GPT-5.5

Background Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT, is increasingly being used for statistical interpretation and research support. While traditional s...

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Using Polygenic Risk Scores to Evaluate Definitions of Self-Reported Sleep Phenotypes Across Cohorts

Sleep disorders are associated with a variety of health outcomes, including cardiovascular disease, diabetes, and Alzheimer’s disease. Previous studies hav

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Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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Evaluation of argatroban to warfarin transition process in heparin-induced thrombocytopenia - Journal of Thrombosis and Thrombolysis

The argatroban to warfarin transition in heparin-induced thrombocytopenia (HIT) is complicated as argatroban falsely elevates the international normalized ratio. The evaluation aims were to assess compliance with institutional guidelines for this transition and transition success. This was a retrospective, single-system, observational cohort study of confirmed HIT patients receiving argatroban with the goal of warfarin transition between January-2019 and June-2024. Data collection included demographics, anticoagulant dosing, venous and arterial thromboses, major and clinically relevant non-major bleeding (CRNMB), and laboratory data. The primary endpoint was compliance with all eight steps of institutional guidelines. Secondary endpoints included individual compliance steps and transition success (defined as completion within seven days and absence of bleeding, thrombosis, non-therapeutic international normalized ratios (INRs) and argatroban restarts). A Fisher’s Exact test assessed the relationship between compliance and outcomes, significance at p < 0.05. Thirty-two argatroban to warfarin courses were evaluated in 29 patients. Compliance occurred in 10/32 (31.3%) of courses. Non-compliance was often due to failure to perform a two-step argatroban discontinuation process with doses > 2 mcg/kg/min (6/14, 42.9%). Transition success occurred in 50% (16/32) of courses. An extended bridge (argatroban and warfarin co-therapy) beyond seven days was the most common reason for failure in 29% (9/31). Bleeding (major and CRNMB) and thrombosis occurred in 18.8% and 6.3% of courses, respectively. There was no relationship between compliance and outcomes. The process for transitioning HIT patients from argatroban to warfarin is complex. The low rate of compliance and transition success highlights the challenging nature of this transition. Graphical Abstract A single center retrospective study assessed outcomes in 32 argatroban to warfarin transition courses in heparin-induced thrombocytopenia. Compliance with institution guidelines for the transition and transition success were low. Bleeding was a greater concern than thrombosis. Future areas of research were identified.

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Practice patterns of DOAC high-intensity period following parenteral lead-in treatment for venous thromboembolism - Journal of Thrombosis and Thrombolysis

In the acute care setting, consensus is lacking on whether patients initially treated with parenteral anticoagulation for venous thromboembolism (VTE) should complete the full high-intensity period (HIP) of apixaban or rivaroxaban. This study examines HIP prescribing patterns following parenteral anticoagulation and assesses the influence of patient, provider, and facility characteristics. Patients initiating rivaroxaban or apixaban for VTE after parenteral anticoagulation were identified from the Michigan Anticoagulation Quality Improvement Initiative (MAQI2) database between November 2015 and March 2024. Those with an indeterminate duration of parenteral treatment were excluded. Patients were categorized into full HIP and shortened HIP cohorts based on DOAC dose and duration. Demographics and comorbidities were compared using Student’s t-test and Chi-squared or Fisher’s exact tests. Variables with p < 0.3 were included in a logistic regression model, with stepwise selection at a 0.1 significance threshold. Among 816 patients, 687 (84.2%) received the full HIP, while 129 (15.8%) had a shortened HIP. Patients with private insurance (OR 0.3 [0.11–0.82], p = 0.02) or Medicare (OR 0.31 [0.11–0.92], p = 0.04) were less likely to receive a shortened HIP than Medicaid patients. Higher HAS-BLED scores were associated with increased odds of receiving a shortened HIP (OR 1.32 [1.1–1.59], p = 0.003). Provider type did not significantly impact HIP prescribing patterns. Despite prior parenteral anticoagulation, most patients completed the full DOAC HIP. Further research is needed to assess how patient, provider, and facility factors influence decision-making and to evaluate the impact of these decisions on clinical outcomes. Graphical abstract

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Optimizing transitions from direct factor Xa inhibitors to unfractionated heparin therapy

AbstractPurpose. Hospitalized patients taking direct factor Xa inhibitors (DFXaIs), such as apixaban and rivaroxaban, often need to be transitioned to unfr

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Determining the Validity of 2D Motion Capture for Estimating Lower Extremity Joint Quasi-Stiffness During Gait in Chronic Stroke Survivors - Sierra A Foley, Andrew F Moul, Chandramouli Krishnan, Edwar...

Altered joint stiffness is common after stroke, yet clinically feasible tools to objectively quantify joint stiffness during walking are lacking. Quasi-stiffnes...

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Real-World Weight Loss With Injectable Semaglutide vs Dulaglutide for Diabetes | AJMC

In this real-world study of patients with type 2 diabetes, treatment with semaglutide resulted in greater reductions in body weight and hemoglobin A1c than dulaglutide.

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Beyond chronological age: biological aging and its relevance for motor and cognitive function in multiple sclerosis

The aging of the global population has profound implications for multiple sclerosis (MS), a disease increasingly affecting older adults. Motor and cognitive impairments are common in both aging and...

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Tumor stroma and its role in therapy resistance: mechanisms and therapeutic opportunities

The tumor microenvironment (TME), composed of cancer, immune, and stromal cells together with the extracellular matrix, plays critical roles in tumor initiation, progression, metastasis, and therap...

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A Bibliometric Analysis of Pharmacist‐Delivered Care: Global Trends, Outcomes, and Practice Settings (2000–2024)

Background As the health care landscape evolves rapidly, the demand for an expanded role of pharmacists is also growing. There is ample literature documenting the positive health outcomes of pharmac...

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Frontiers | No associations between blood pressure and brain volumes in a convenience sample of Hispanic/Latino middle-aged and older adults

BackgroundHigh blood pressure (BP) is a known risk factor for dementia, but the relationships between BP and gross brain volumes are mixed and are understudi...

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Promise to Practice: Reimagining Artificial Intelligence for Equitable Global Health Impact | Annals of Global Health

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Navigating mental health conversations: Student pharmacists complete Mental Health First Aid Training and apply it through experiential learning in a community pharmacy depression screening program

Background: Community pharmacies offer a unique and accessible opportunity to close the existing mental health care gap. Many pharmacists and student pharmacists, however, lack the confidence to effec...

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Life's Essential 8 and cerebrovascular disease among Hispanic/Latino adults: findings from the Hispanic Community Health Study/Study of Latinos and Study of Latinos‐Investigation of Neurocognitive Agi...

INTRODUCTION Better cardiovascular health (CVH) is associated with better cognitive function, but limited data exist on its association with cerebrovascular disease (CVD) burden using the Life's Ess.....

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