Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Astrocyte-specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1-dependent CXCL10 expression. These changes synergistically promote periph...

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Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identi....

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Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Ferroptosis modulation enhances astrocyte-to-neuron conversion induced by a novel chemical cocktail in the hemorrhagic brain

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An Orthogonal Near-Infrared Optical Switch for Wireless Neuromodulation in Freely Behaving Mice

Abstract. Modulating neuronal activity with light is a powerful tool for neuroscience research. However, currently available technologies often require inv

pubs.acs.org

Hippocampal neuronal progranulin mediates estrogen‑deficiency‑induced affective vulnerability and lysosomal-autophagic dysfunction - Molecular Psychiatry

Molecular Psychiatry - Hippocampal neuronal progranulin mediates estrogen‑deficiency‑induced affective vulnerability and lysosomal-autophagic dysfunction

nature.com

The basolateral amygdala decodes visceral pain and itch via distinct circuits and molecules - Nature Communications

The authors find that the basolateral amygdala acts as a critical sorting hub, segregating visceral pain and itch through distinct circuits and molecular markers. This discovery provides a basic frame...

nature.com

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy

Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid immunoth...

science.org

HCN1 channels in GABAergic amygdalar neurons underpin male-biased aggressive behaviors

By elucidating the intricate molecular and functional architecture of the pSI, Li et al. reveal that testosterone hyperexcites pSIVgat neurons via HCN1 upregulation to drive male-biased aggression in ...

cell.com

Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus - Nature Neuroscience

Bright light reduces feeding and weight gain in mice by activating a specific retina-to-brain pathway that signals through the visual thalamus to inhibit appetite-regulating neurons in the hypothalamu...

nature.com

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

RLIM-mediated SLC7A11 polyubiquitination is required for SPTBN2-mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis...

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A cortical-hypothalamic neural circuit for compulsive eating in mice

Binge-eating disorder (BED) is the most common eating disorder and is strongly associated with obesity. The medial prefrontal cortex (mPFC) has been i…

sciencedirect.com

cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy - Nature Neuroscience

Huang et al. found that stressed neurons release DNA that activates the immune sensor cGAS, driving inflammatory responses that worsen seizures and mortality in Dravet syndrome. Blocking cGAS interrup...

nature.com

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell-type–specifi...

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Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit - Nature Communications

The role of mediodorsal thalamus inputs to the orbitofrontal cortex in learning remains unclear. Here authors show that these inputs are required for associative learning and regulate learning-depende...

nature.com

AAV9-mediated GAA gene therapy following enzyme replacement therapy discontinuation in children with infantile-onset Pompe disease

While our previous research showed that a single infusion of recombinant AAV9-mediated GAA gene therapy enabled infants (<1 year) with infantile-onset…

sciencedirect.com

MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants - Molecular Psychiatry

Molecular Psychiatry - MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants

nature.com

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy

Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid immunoth...

science.org

A sync state in the midbrain dopamine network for interoceptive nutrient learning

Yang et al. show that a subpopulation of VTA dopamine neurons enters a distinct low-frequency synchronous state during novel food consumption. Emerging during oral-gastric overlap, this state mediates...

cell.com

Dyscoordination of thalamic reticular spindles is associated with social memory deficits in mice and humans with autism spectrum disorder - Nature Communications

The relationship between sleep spindles and social memory is not fully understood. Here authors identify a thalamic sleep spindle circuit that supports social memory consolidation and is disrupted in ...

nature.com

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging

Fang et al. show that BBB leakage during aging begins in midlife and results from increased endothelial caveolar transcytosis rather than tight junction disruption. Elevated TGF-β1 suppresses Mfsd2a v...

cell.com

WTR: A Toolkit for Functional Anterograde Transsynaptic Circuit Mapping

The brain coordinates animal physiology and behavior via neuronal circuits. To understand and simulate brain functions, it is essential to delineate the synaptic connectivity between neurons. Transsyn...

biorxiv.org

Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety - Molecular Psychiatry

Molecular Psychiatry - Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety

nature.com

Increased activity of DRD1-MSNs in dorsolateral striatum underlies Cry1Δ11 mutation-induced repetitive behaviors - Translational Psychiatry

Translational Psychiatry - Increased activity of DRD1-MSNs in dorsolateral striatum underlies Cry1Δ11 mutation-induced repetitive behaviors

nature.com

Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia

Distinct STN neuron populations differentially regulate LID via projections to EP and RtTg.

science.org

Multi-Omics Analysis Reveals Nono–Kcnq2 Regulation of Neuronal Excitability in Chronic Constriction Injury-Induced Neuropathic Pain | Research

Neuropathic pain, resulting from somatosensory nervous system damage or disease, is a debilitating condition marked by spontaneous pain, hypersensitivity, and sensory abnormalities. Neuropathic pain i...

spj.science.org

Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance - The Journal of Headache and Pain

Background Chronic pain can cause both hyperalgesia and cognitive impairment symptoms and involves long-term alterations in the neural circuits, leading to abnormal cortical activity. GABAergic signal...

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Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal–prefrontal synchrony - Nature Neuroscience

Yu, Zhang et al. show that repeated exposure to the psychedelic drug 25C-NBOMe in adolescent rats, but not in adult rats, reduces willingness to engaged in food resource competition in adulthood, due ...

nature.com