Not often you get to say two papers dropped the same day 😱🎉🥳🍾 Incredibly proud of both — great science, amazing collaborators, and a lot of hard work 💪 #Virology #Bunyavirus #EmergingViruses

Pre-print: our description of RZ affiliate ZNFX1 is now online. On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution. Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social www.biorxiv.org/content/10.1...

ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX...

biorxiv.org

Curious about tick virology? Read my latest piece in @uk.theconversation.com where I explain findings of my latest research article www.nature.com/articles/s41... Hope it will helps people to understand the importance of studying tick and their pathogens #ScienceforAll #WomenInScience #Arbovirose

The Conversation UK@uk.theconversation.com · 12mo ago

Research shows how ticks survive deadly passengers and what it means for stopping future outbreaks.

📢 Thrilled to share our NEW PREPRINT! SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠 🧫 NSs essential for tick but not mammalian infection 🧬 Binds 22-nt viral siRNAs to block RNAi 🕷️ Reveals host-specific viral immune evasion 📖 doi.org/p2vf #lovevirology #bunyavirus #tickborne

SFTSV NSs protein is a novel tick antiviral RNAi response suppressor

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...

doi.org

Thread: How Viruses Hijack Tick RNA Machinery 🧬🕷️ Post 1/5 🧵 We just published the first map of how viruses rewire tick cell RNA machinery! Led by Alexandra Wilson & Wael Kamel! We Found 283 proteins that change RNA-binding during Uukuniemi virus infection. 📄 Our paper: doi.org/10.1371/jour...

Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...

doi.org

Lovely time celebrating Andrew’s PhD Graduation last week 🎓🎉🍾 #nextsteps #lovevirology #bunyavirus

Scientists uncover how ticks fight off and carry a virus deadly to humans @virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social @uniofsurrey.bsky.social #SFTSV

Scientists uncover how ticks fight off and carry a virus deadly to humans

The study, published in Nature Communications, provides the most detailed picture yet of how cells from the tick species Rhipicephalus microplus respond to infection with severe fever with thrombocytopenia syndrome virus (SFTSV).SFTSV can cause high fever, internal bleeding and death in humans and currently has no licensed treatment or vaccine.

bit.ly

Finally A BIG THANK YOU to all my co-authors, they made this long journey started in 2021 a bit smoother! Thanks to Scaturro lab, Kohl lab, @brennanlab.bsky.social, @quangu.bsky.social, and Dundee proteomics! And of course thanks to the Tick cell Biobank and Lesley for those tiny cells!

OMG! I can finally share my joy to see my SFTSV work published in @natcomms.nature.com! This adventure started by the award of my MSCA grant and my move to the Kohl and @brennanlab.bsky.social at @cvrinfo.bsky.social. Let's chat about how we discovered novel tick anti-viral effectors!

Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications

Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...

nature.com