Huge thanks to Elisa, a PhD student from Prof. Vittoria Colotta's lab (University of Florence), who finished her internship with us last week! 👋 Elisa joined us to test their CK1δ/ε inhibitors in our cell-based assays. It was a pleasure to have you, and we'll miss you in the Western blot room! 🎉

We love collaborations - especially across the campus! 🧬🙏 Our alumnus Miroslav Micka shares the story behind our long-standing collaboration with Konstantinos Tripsianes' lab @ceitec.eu that led to our recent Science Advances paper on Dishevelled protein 🎤👇 www.ceitec.eu/two-worlds-o...

Hallo from Belgium! 🧇 Our student @antoniamikulova.bsky.social sends greetings from her internship in the lab of @meningojan.bsky.social at VIB-KU Leuven Center for Cancer Biology where she studies immune cells in context of CNS pathologies.🧠 Many thanks to Jan and his group for their warm welcome 🙌

Walks, sports, cooking, singing around the campfire, and much more 🌿 That was our last week’s labretreat deep in the woods. Highly recommending the reset in nature. 💆‍♀️🌲

Thrilled to see our study out in Science Advances 🔥 www.science.org/doi/10.1126/...

A Wnt-induced conformational phospho-switch in DVL3 controls association with Frizzled receptors and Wnt/β-catenin signaling

A threshold-based phospho-switch of DVL mediates Wnt signaling and rationalizes DVL’s domain architecture.

science.org

Bryjalab@bryjalab.bsky.social · 11mo ago

Excited to share our new preprint on bioRxiv. 🎉 We uncovered a Wnt-induced phospho-switch of Dishevelled. This intramolecular coupling is mutually exclusive with FZD engagement and functionally required for the Wnt/β-catenin signaling. 🧵 doi.org/10.1101/2025...

👋Greetings from Plön, where our master’s student Nela Kolčáková is doing an internship at @mpi-evolbio.bsky.social, diving into dev bio and evo-devo! Huge thanks to @marketa-kau.bsky.social and her lab for showing her the diversity of model organisms - from mice, fish to even lizards and sharks! 🐭🦎🦈

A look back at the 2nd EHA-SWG Scientific Meeting on MDS/MPN/AML, where our lab members Pavlína Janovská and Patrik Matušů presented their research on CK1 inhibition in AML and discussed its potential with leading hemato-oncologists. 🙏Thanks to everyone for the great meeting and valuable feedback!💊🥼

Big congrats to @petrakompanikova.bsky.social and Štěpán Čada on defending their PhDs last Friday 🎓 Thanks to everyone who came to celebrate their big day with us! 🍾🎉

Proud to share our new paper! 🎉🍾 To cure chronic lymphocytic leukemia (CLL), it might be hard to determine what to target first - the intrinsic machinery of CLL cells or the pro-leukemic microenvironment? This study shows that casein kinase 1δ/ε inhibition does both, leading to CLL suppression.👀👩‍🔬🧵

Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell‐intrinsic and microenvironmental mechanisms

Chronic lymphocytic leukemia (CLL) is a consequence of pathological B-cell accumulation in blood and lymphoid organs. Due to high refractoriness, CLL is still incurable in many cases; therefore, ther...

onlinelibrary.wiley.com

🎤 Another day, another interview (cz) This time our PI Víťa appears in the latest issue of @vesmir.bsky.social - a Czech popular science journal - talking about his academic journey and focus on cell signalling and leukemia research. 🧑‍🔬 👇 vesmir.cz/cz/casopis/a...

Jen počkej, leukemie!

Řidičů tramvaje nebo popelářů jsou plné mateřské školky. Čas tuhle ranou romantiku setře, díky čemuž občas patentový úřad zaznamená nový vynález nebo lidstvo obohatí své poznání o dosud neznámou zákon...

vesmir.cz

Something a bit different for the weekend 🎥 🎤 An interview from French BFMTV (EN) featuring our PI Víťa, this time as a founder of CasInvent - a company developing selective Casein Kinase 1 inhibitors 🔬 Worth a watch 👇 www.bfmtv.com/pratique/ent...

CasInvent : la biotech tchèque qui ouvre une nouvelle voie contre les cancers résistants

Depuis Brno, en République tchèque, CasInvent se distingue par une approche inédite dans la lutte contre les cancers les plus agressifs. Issue de l’Université Masaryk, la jeune biotech développe une n...

bfmtv.com

Big congrats to our PhD student Patrik Matušů on winning the Brno PhD Talent award for his project on CK1 and AML 🎉 Very well deserved 👏 www.jcmm.cz/projekt/brno...

Big Bryjalab delegation at the 13th International Conference on Analytical Cytometry in beautiful Mikulov! Many thanks to the organizers for such a wonderful meeting & Bike scientific discussion. 🚴‍♀️ Proud of our PhD students @antoniamikulova.bsky.social and Štěpán Čada for their great talks! 🤗🧵

🎉 Pleased to collaborate again with Buchtová lab, where @petrakompanikova.bsky.social’s bioinformatics skills contributed to uncovering new roles of LGR5 in the formation of teeth 👩‍💻🐁

Petra Kompanikova@petrakompanikova.bsky.social · 10mo ago

Ever wondered how molars are formed? 🦷 Check out this new preprint from Marcela Buchtova’s lab on the role of LGR5 in sequential tooth development 🐁👩‍🔬 www.researchsquare.com/article/rs-7...

Excited to share our new preprint on bioRxiv. 🎉 We uncovered a Wnt-induced phospho-switch of Dishevelled. This intramolecular coupling is mutually exclusive with FZD engagement and functionally required for the Wnt/β-catenin signaling. 🧵 doi.org/10.1101/2025...

A Wnt-induced conformational phospho-switch in DVL3 controls interaction with Frizzled receptors and Wnt/β-catenin signaling

When Wnt ligands bind to Frizzled (FZD) receptors, Dishevelled protein (DVL) gets multiphosphorylated by Casein kinase 1 (CK1). Although, it is well known that DVL phosphorylation relays Wnt signals f...

doi.org

Big day for Bryjalab yesterday! Mirek Micka & Tomáš Gybeľ nailed their defences — welcome to the PhD club! 🎓🔥 Thanks to everyone who supported them along the way and came to celebrate! 🎉🤗

The science marathon continues. 🏃 Straight off #EBBM2025, BryjaLab is co-organizing with Tripsianes’ lab at @ceitec.eu the Milestone Minisymposium on Cell Signalling, kicking off today with great talks by @chriswaudby.bsky.social & @michaelranes.bsky.social. More talks & two PhD defenses tomorrow 🎓

Grind stays real – Víťa and @petrakompanikova.bsky.social went straight from the V4SDB Meeting 2025 to the European Brain Barrier Meeting in Bern, where Petra presented her work on the hindbrain choroid plexus. 🐁 Big thanks to the organizers and community for the warm first-time welcome! 😇 #EBBM2025

Last week we joined the @v4sdb.bsky.social Meeting 2025 in the beautiful High Tatras 🌄 with an amazing lineup of speakers and posters 🔥 So good to see this society still rocking!

First-ever CK1 Protein Kinase Family conference took place in Brno, bringing together nearly 80 researchers from around the world to share the latest findings on CK1 biology, disease links, and therapeutic potential. Thanks for the inspiring talks, posters & great networking – see you next time! 🎉🥳

🎉 We’re thrilled to announce that the MILESTONE International CK1 Conference is happening July 21–23, 2025, in Brno, CZ! 🫛 Join us to explore CK1 kinases in cell signaling, cancer, neurodegeneration, therapy & more! Registration’s open now! Looking forward to meeting you all there! 🤗 ck1.sci.muni.cz

MILESTONE International Conference | MILESTONE International Conference CK1 | MUNI SCI

CK1 protein kinase family: From cell signaling to therapeutic targets in human disease

ck1.sci.muni.cz

🍾 New preprint alert! We were happy to methodologically participate in the project that targets the regulation of RNA Polymerase II transcription by RECQ5-mediated LLPS. 🧊🔬 Huge thanks to the Richard Štefl Lab and @labvacha.bsky.social for this opportunity! 🤗 www.biorxiv.org/content/10.1...

Mechanisms of transcription attenuation and condensation of RNA polymerase II by RECQ5

The elongation rates of RNA polymerase II (RNAPII) require precise control to prevent transcriptional stress, which can impede co-transcriptional pre-mRNA processing and contribute to many age- or dis...

biorxiv.org

🥳New paper from the lab!🍾 Excited to share our work with the Stefan Knapp lab (Goethe Uni, @thesgc.bsky.social & DKTK), published in J. Med. Chem. @pubs.acs.org. Here, we present the first degraders (PROTACs) targeting CK1 δ/ε—highly selective across the kinome & within the Casein kinase 1 family. 🧵

Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε

Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit from isoform...

pubs.acs.org

📢 Greetings from Dundee! Our PhD student Tomáš Gybeľ sends his best from his internship in the Sapkota lab at the University of Dundee, where he is studying CK1 and the Fam83 protein family in Wnt signaling. 🌍🔬 Big thanks to Prof. Sapkota and his team for their warm welcome and support! 🤗

Bryjalab attended the 25th Prague Hematology Days 🩸, presenting our work on ROR1+ B cells in CLL, CK1 inhibitors in AML, and the effect of CK1 inhibition + Venetoclax on specific AML clones. 👩‍⚕️👩‍🔬 Huge thanks to the organizers for the chance to share our research with scientists and clinicians! 🤗

Our PhD student @petrakompanikova.bsky.social is helping organize this amazing conference with a really impressive lineup of invited speakers. Follow her and @v4sdb.bsky.social for updates, and hope to see you all in the High Tatras!

Petra Kompanikova@petrakompanikova.bsky.social · 2y ago

The V4SDB Meeting 2025 is heading to the stunning High Tatras! 🌄 The website is live—discover our stellar speakers, exciting program (including a student workshop), and unforgettable surroundings. Don’t miss this top event happening in September—registration opens March 1! 🤗 @v4sdb.bsky.social

Today, during the Open Day at the Faculty of Science, Masaryk University, I had the chance to help my department showcase our research and guide prospective bachelor students through our labs. 🔬🧪 I hope we sparked some interest and inspired a future scientist! ✨👩‍🔬👨‍🔬

🚨Preprint alert🚨 We're excited to share our latest findings on the Wnt/planar cell polarity (Wnt/PCP) pathway, a critical signaling cascade for cell biology, development, and disease. 🧵👇 www.biorxiv.org/content/10.1...

Proximity interactomics identifies RAI14, EPHA2 and PHACTR4 as essential components of Wnt/planar cell polarity pathway in vertebrates

Wnt/planar cell polarity (Wnt/PCP) pathway is an evolutionarily conserved signaling cascade playing an inevitable role in cell biology. Deregulation of Wnt/PCP leads to severe developmental defects or...

biorxiv.org

Hi Bluesky! 🌌 We are Bryjalab – the Laboratory of Cellular Communication 🧬 at Masaryk University, Brno, Czech Republic. From development 🐣 to disease 🩺, we explore the mechanisms and effects of Wnt signaling cascades. 🧵 Follow us for more Wnt updates! 🚀