Such a crucial question. We are trying to find ways that enable scaling at ~1000x with learning the fundamentals - this is an challenge but essential

Natalia Sampaio@drnatsampaio.bsky.social · 3w ago

#Biomni is amazing, but I am missing a critical point from the discussion: What is the long-term influence of these tools on trainees? Will trainees ever become experts if they never do the work? Autonomous biomedical research with an artificial intelligence agent www.science.org/doi/10.1126/...

Proud to contribute to a seminal study in #ScienceMagazine revealing the importance of #ILC2-#Pi16+ #Fibroblast interactions in the pancreas. Forever grateful to @timotheus_halim & congrats to the co-authors! tinyurl.com/fmypdbme buechlerlab.com

ILC2s regulate a fibroblast progenitor niche in the pancreas

Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...

tinyurl.com

The #buechlerlab is looking for #postdoc(s) to study how #fibroblasts control #inflammation and #immunity. Please see below and reach out if you are interested~ www.buechlerlab.com

Tour du force on how #fibroblast subsets can drive rheumatoid arthritis in #natureimmunology. Huge congrats to @arthritisbham, Mark Coles and team at #Oxford. Check it out: www.nature.com/articles/s41...

The embryonic origins of site-specific arthritis - Nature Immunology

Davidson et al. map the cellular and structural composition of developing joints and identify fibroblast populations that may predispose joints to inflammatory arthritis.

nature.com

Congrats to Drs. Shyer, Vander Heiden, Turley and team for leading an important study of #fibroblast development, diversification and function in fibrosis published in #PNAS. Happy to have contributed expertise from #UofT, #Sickkids and #UnityHealth in Toronto. Check it: www.pnas.org/doi/10.1073/...

We are looking for motivated scientists to join our team, please reach out if you feel you are a good fit~

We are interested in adding #postdocs. If you like a fabulous team, city and research environment and are interested in #cellularengineering / #sytheticbiology, #ILCfibroblast interactions or #skin #fibrosis, contact me with your CV & interest statement. www.buechlerlab.com

Thank you to Rundong Jiang & Johann E. Gudjonsson for their News and Views piece on our recent Nature Immunology article! Check it out~ www.nature.com/articles/s41...

So glad to share our new work in #NatureImmunology highlighting that #fibroblast-#macrophage dialogue is a cornerstone of skin integrity in health and disease. Big congrats to all the authors at #UofT and #Genentech for their tireless efforts. Looking for #PDs to continue this work~ rdcu.be/e50PJ

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity

Nature Immunology - Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is...

rdcu.be

Interested in utilizing novel genetic tools to unpack the #immunology of #fibroblasts in #regenmed, #cancer, #metabolism, #osteoarthritis or #fibrosis and hope to make a dent in the universe? We are looking for #postdocs and #Canada is offering amazing opportunities for funding. www.buechlerlab.com

Thanks for a wonderful session #iuis2025 and #csi for the fabulous session on #fibroblasts and #stroma in #immunity! See you all in 2028 in Toronto!

The Buechler and Kapoor labs are teaming up to find a talented postdoc to work jointly between our labs at UofT/UHN. If you want to make a dent in the universe, please DM. #Immunology #fibroblast www.buechlerlab.com and www.kapoorlab.ca

Happy to share a preprint on how #fibroblasts maintain a niche for #macrophages in the skin. A fab collaborative effort between PDs and trainees at #uoft and #genentech. www.biorxiv.org/content/10.1... www.buechlerlab.com

Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche

Fibroblasts are present in all tissues and are crucial for maintaining tissue homeostasis. We previously identified fibroblasts marked by Dermatopontin ( Dpt ) but their role in supporting macrophage ...

biorxiv.org