Our study on medically important antibacterial binding to a ribosomal small subunit is on the cover of this issue of Biochemistry! pubs.acs.org/bichaw/issue...

Volume 65 Issue 14 | Biochemistry | ACS Publications

Biochemistry publishes exceptional rigorous high-impact research across all of biological chemistry.

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Had a great time presenting my work today at the Boston Bacterial meeting! Stop by my poster tomorrow #152 #BBM2026

JB Editor's Choice: Pope, Paczkowski et al. find RhlR ligand-binding pocket mutants that enhance sensitivity to C4HSL w/o changing selectivity & see specific effects on phenazine gene expression, uncovering a new means to tune QS systems. journals.asm.org/doi/10.1128/... @asm.org #JBacteriol

Our paper is out today as an ASAP web publication in Biochemistry! Congrats to Swati Manjari and @calebmallery.bsky.social! pubs.acs.org/doi/10.1021/...

How Medically Important Antimicrobials Bind to the 30S Ribosomal Subunit in a Bacterial Pathogen

Ribosomes translate the genetic code in mRNA to synthesize proteins in all living organisms. Decoding of mRNA occurs in the small subunit of the ribosome and is mediated by tRNA anticodons. Regions ne...

pubs.acs.org

In other exciting news, I am beyond excited to share that I officially received a notice of award for my F31 fellowship! Really grateful for the support from my mentor and look forward to continuing this work.

Quorum sensing regulation is no joke! Had a great time writing this review, learning from the past and thinking about the future of LuxR-type receptor research.

Jon Paczkowski🌹@paczkowskilab.bsky.social · 6mo ago

A true labor of love for @calebmallery.bsky.social is out now in PLOS Pathogens: a review article where we highlight current and emerging examples of key protein-protein interactions with LuxR-type receptors that control community behaviors and pathogenesis. journals.plos.org/plospathogen...

Very excited about this, really cool work! Glad I was able to contribute during my rotation with @nilesh-banavali.bsky.social

Nilesh Banavali@nilesh-banavali.bsky.social · 9mo ago

1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...

What started out as a structure-function project for an undergraduate researcher morphed into something bigger w/ @popea.bsky.social leading the way. Check out how RhlR fine tunes its response to its autoinducer to avoid producing too much pyocyanin. www.biorxiv.org/content/10.6...

RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes in Pseudomonas aeruginosa

Bacteria control individualistic and group behaviors using a form of cell-cell communication called quorum sensing. Quorum sensing relies on the production of chemical signals called autoinducers and ...

biorxiv.org

First submission of the BlueSky era. @calebmallery.bsky.social & @ksimanek.bsky.social team up to figure out why some LuxR-type receptors might need accessory proteins to regulate gene expression. www.biorxiv.org/content/10.1...

Evolution of PqsE as a Pseudomonas aeruginosa-specific regulator of LuxR-type receptors: insights from Pseudomonas and Burkholderia

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that poses a significant public health threat, particularly in healthcare settings. A key determinant of P. aeruginosa virulence is the...

biorxiv.org