Caner Saygin, MD

@canersaygin.bsky.social

Leukemologist at the University of Chicago

Voting has started for #ASH26 elections. We are rooting for Dr Wendy Stock running for Vice President! She is an incredible hematologist, researcher, mentor, sponsor and advocate. She has made enormous impact on so many lives and careers, including mine. So please vote!

How should we incorporate molecular data in treatment decisions for ALL? It is time to pay more attention to genetic heterogeneity of adult ALL before we decide therapy. Targeted therapies are rapidly emerging, and replacing chemo in ALL. Our review at Blood Cancer Discovery is out today! Link👇

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We are very excited to share our work investigating menin inhibition in T-ALL, led by Kate Shimamoto and Arda Karaoglu, just published in Mol Cancer Therapeutics. We found that high p-MEF2C S222 can predict menin inhibitor response, better than HOX gene expression levels, in T-ALL. rb.gy/oroosm

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InO + TKI has robust activity but limited toxicity when drugs are given sequentially. Great option for older adults with Ph+ ALL in frontline.

Anand Patel@anand-88-patel.bsky.social · 9mo ago

Got to present our Ph+ ALL TKI plus inotuzumab study at #ASH25! Highlights: -all patients achieved MR4 or NGS negativity -VOD seen with initial schema, updated schema splitting InO and TKI had no VOD -80% OS and 76% EFS with no CNS relapse, one systemic relapse, and no allo-HCT

Very excited to share our paper investigating the evolution of therapy-related CH in myeloma pts treated w/ or w/o LEN. Can we predict the risk for second blood cancer in myeloma pts? Grateful for the collaboration with @uchicagocancer.bsky.social myeloma program. www.nature.com/articles/s41...

Evolution of clonal hematopoiesis on and off lenalidomide maintenance for multiple myeloma - Leukemia

Leukemia - Evolution of clonal hematopoiesis on and off lenalidomide maintenance for multiple myeloma

nature.com