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Carrie Sokol

@carriesokol.bsky.social

Immunologist & physician-scientist at Massachusetts General Hospital and Harvard Medical School interested in all things itchy and allergic.

38 Posts2093 Follower 957 Folgt

ImmuNoah's Ark (Noe Rodriguez)@immunoah.bsky.social · 2w ago

Really nice to see out this interesting study from @carriesokol.bsky.social Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity: Immunity www.cell.com/immunity/ful...

Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

cell.com

Jonathan Kagan @jkagan1.bsky.social · 2w ago

A metabolic regulator in neurons controls allergic inflammation. Fascinating and important study by Sokol and colleagues key insight to a growing health problem. Kudos to the authors. www.cell.com/immunity/ful... @carriesokol.bsky.social

Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

cell.com

Carrie Sokol @carriesokol.bsky.social · 2w ago

1/ Why can you encounter an allergen repeatedly before becoming allergic to it? In our new @cp-immunity.bsky.social paper, led by the wonderful Xueping Zhu, we asked whether the sensory neurons that first detect allergens might carry a record of earlier exposures. 🧵 www.cell.com/immunity/ful...

Sensory neuronal mTORC1 kinase signaling establishes neuroimmune memory that initiates allergic immunity

cell.com

Kumar Thurimella, PhD @00kumar.bsky.social · 8mo ago

1/ Our paper is out today in @cp-cellsystems.bsky.social. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome. www.cell.com/cell-systems...

Identifying microbial protease allergens through protein language model-guided homology

Thurimella et al. introduce a deep learning framework using protein language models to predict allergenic proteases in the microbiome. The model identified hundreds of candidate allergenic proteases i...

cell.com

Carrie Sokol @carriesokol.bsky.social · 8mo ago

What if we’ve dramatically underestimated the allergenic universe? Our new collaborative paper asks a simple but radical question: Can we teach AI what makes a protease an allergen — and then use it to discover new ones? (1/x) 🔗 www.sciencedirect.com/science/arti...

Identifying microbial protease allergens through protein language model-guided homology

Emerging research links the gut, skin, and oral microbiomes to allergies, with serine proteases (SPs) identified as potential allergens. This study le…

sciencedirect.com

Carrie Sokol @carriesokol.bsky.social · last yr.

Thanks for the highlight @immunoah.bsky.social ! I had an amazing time sharing our new science!

ImmuNoah's Ark (Noe Rodriguez)@immunoah.bsky.social · last yr.

Great insight by @carriesokol.bsky.social on why we may develop allergy after multiple exposures to allergens! #CSNeuroimmune25

Carrie Sokol @carriesokol.bsky.social · last yr.

Meet my lab, friends! www.linkedin.com/posts/mgbres...

🤧 Why do we get allergies, and why do they make us itch, sneeze and swell? | Mass General Brigham Research

🤧 Why do we get allergies, and why do they make us itch, sneeze and swell? Caroline Sokol, MD, PhD, an allergy researcher at Mass General Brigham and the Food Allergy Science Initiative, is uncoverin...

linkedin.com

Achille Broggi🧪👨🏼‍🔬🔬@achillebro.bsky.social · 2y ago

👨‍🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5

Carrie Sokol @carriesokol.bsky.social · 2y ago

In Rio for ACMI 2024! All barrier (or mucosal, but we can fight over it) all the time!

Carrie Sokol @carriesokol.bsky.social · 2y ago

Alert! New science from the lab is hot off the press! www.nature.com/articles/s41... Before I describe the findings, let’s set the stage. The lab has always been interested with how allergens are detected. They don’t infect us, so why do we detect them and who does the detecting? (1/x)

A γδ T cell–IL-3 axis controls allergic responses through sensory neurons - Nature

A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs sensory neuronal responses t...

nature.com

Carrie Sokol @carriesokol.bsky.social · 2y ago

Dusting off my social media profiles as we get ready to share some exciting new findings on the neuroimmune control of allergic immunity. Stay tuned for more updates!

snow white from snow white and the seven dwarfs is looking at a ghost .

ALT: snow white from snow white and the seven dwarfs is looking at a ghost .

media.tenor.com

Carrie Sokol @carriesokol.bsky.social · 3y ago

Science communication is not always easy, but part of being an academic is teaching everyone - not just our peers - about what and why we “science”. It was great to be a part of this and so excited to see future segments! immunologyexplained.aai.org

Immunology Explained - Home

The immune system intersects with almost every aspect of human health and disease. Its functions, both when things are going well and when things go wrong, are immensely complicated. The American Asso...

immunologyexplained.aai.org

Rod Rahimi @rodrahimi.bsky.social · 3y ago

Cool paper by Jason Griffith and the Luster lab on a novel mechanism of Treg suppression. IL-33 instructs ST2+ Tregs to produce the IL-1 antagonist IL-1Ra, which restrains IL-1-mediate innate immunity. #Immunosky www.nature.com/articles/s41...

Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection - Nat...

Luster and colleagues report that lung-resident ST2+ regulatory T cells secrete the IL-1 antagonist IL-1Ra to suppress neutrophils and early innate immune responses to influenza virus infection.

nature.com