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SCIENTIFIC JOURNAL group by @SpringerNature Cell Death & Differentiation, Cell Death & Disease, Cell Death Discovery
“Associative memory plays a role in ER-1α positive breast cancers” This timely Perspective raises the question of whether concepts from neural networks and machine learning can provide a unifying framework for understanding gene regulatory networks ⤵️ www.nature.com/articles/s41...
“LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming” This study defines LSD1 as a critical epigenetic-metabolic regulator in #PDAC whose therapeutic targeting requires subtype stratification ⤵️ www.nature.com/articles/s41...
LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming - Cell Death & Disease
Cell Death & Disease - LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming
nature.com
“Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer” The dual inhibition unleashes rapid, irreversible, and p53-independent #Apoptosis in #NSCLC ⤵️ nature.com/articles/s41...
Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer - Cell Death & Differentiation
Cell Death & Differentiation - Dual targeting of BCL-XL and MCL-1 exposes a rapid and exploitable apoptotic vulnerability in non-small cell lung cancer
nature.com
“Rewiring cell death, metabolism and immunity in precision medicine: insights from the CDDisease 12th Meeting” Find the Meeting Report here ⤵️ www.nature.com/articles/s41...
Rewiring cell death, metabolism and immunity in precision medicine: insights from the CDDisease 12th Meeting - Cell Death & Disease
Cell Death & Disease - Rewiring cell death, metabolism and immunity in precision medicine: insights from the CDDisease 12th Meeting
nature.com
“Cooperation and constraint: the complex association of caspase-8 and cFLIP” Explore this insightful editorial by Dr Bibo-Verdugo and Prof Salvesen ⤵️ nature.com/articles/s41... Read more about the related research article in the thread below 1/2
Cooperation and constraint: the complex association of caspase-8 and cFLIP - Cell Death & Differentiation
Cell Death & Differentiation - Cooperation and constraint: the complex association of caspase-8 and cFLIP
nature.com
🎗️World Head and Neck Cancer Day🎗️ Explore our collection of related research articles in: Cell Death and Disease: nature.com/subjects/hea... Cell Death and Discovery: nature.com/subjects/hea... #HeadAndNeckCancerDay #CancerAwarness
“TMBIM6: at the intersection between proteostasis dysregulation and Parkinson’s disease” New editorial by Claudio Hetz & Béatrice Bailly-Maitre ⤵️ nature.com/articles/s41... Read more about the related research article, published in Cell Death & Disease, in the thread below 1/2
“The mechanism of 45S5 bioactive glass-mediated, cell-type-specific death of bone tumor cells” These findings may contribute to the design of suitable BG-particles, paving the way for novel therapeutic strategies to treat #BoneTumour ⤵️ www.nature.com/articles/s41...
The mechanism of 45S5 bioactive glass-mediated, cell-type-specific death of bone tumor cells - Cell Death Discovery
Cell Death Discovery - The mechanism of 45S5 bioactive glass-mediated, cell-type-specific death of bone tumor cells
nature.com
“Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation” This work establishes a mechanistic and functional connection between #InnateImmunity aging and systemic #Aging ⤵️ www.nature.com/articles/s41...
Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation - Cell Death & Differentiation
Cell Death & Differentiation - Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation
nature.com
“Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis” This study demonstrates that #dexamethasone exerts temporally divergent effects on #ferroptosis during #AcuteKidneyInjury ⤵️ www.nature.com/articles/s41...
Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis - Cell Death & Disease
Cell Death & Disease - Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis
nature.com
"The landscape of the ubiquitin-proteasome system in cancer" An elegant editorial written by Prof. Amir Orian and #Nobel laureate Aaron Ciechanover ⤵️ nature.com/articles/s41... Read more about the two related research articles in the thread below 1/3
The landscape of the ubiquitin-proteasome system in cancer - Cell Death & Differentiation
Cell Death & Differentiation - The landscape of the ubiquitin-proteasome system in cancer
nature.com
A new way to modulate #ImmuneSuppression in NSCLC: Tumour-infiltrating regulatory #Tcells in #LungCancer rely on the pro-survival protein MCL-1. Blocking MCL-1 can weaken Tregs and briefly boost anti-tumour CD8+ T cells ⤵️ www.nature.com/articles/s41...
Repurposing BH3 mimetics to deplete tumour-infiltrating regulatory T cells and enhance anti-tumour immunity in non-small cell lung cancer - Cell Death & Differentiation
Cell Death & Differentiation - Repurposing BH3 mimetics to deplete tumour-infiltrating regulatory T cells and enhance anti-tumour immunity in non-small cell lung cancer
nature.com
“Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy” New insights into the role of Gpx8 in modulating the tumor microenvironment ⤵️ www.nature.com/articles/s41...
Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy - Cell Death & Differentiation
Cell Death & Differentiation - Targeting of Gpx8-CSF1 axis resets the immune milieu of lung tumor and overcomes resistance to anti-PD-1 therapy
nature.com
“Multi-omic single nuclei profiling of murine pancreas shows dynamic epigenetic heterogeneity of acinar cells” Paired sequencing of cell #Transcriptome and #Epigenome reveals surprising tissue heterogeneity and mechanisms of tissue homeostasis ⤵️ www.nature.com/articles/s41...
Multi-omic single nuclei profiling of murine pancreas shows dynamic epigenetic heterogeneity of acinar cells - Cell Death & Differentiation
Cell Death & Differentiation - Multi-omic single nuclei profiling of murine pancreas shows dynamic epigenetic heterogeneity of acinar cells
nature.com
“Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation” Don't miss this new Comment by Prof Boyi Gan and colleagues in CDD ⤵️ www.nature.com/articles/s41...
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
nature.com
“SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma” Beyond their canonical role, snoRNAs can modulate chromosomal localization of epigenetic factors to regulate gene expression ⤵️ www.nature.com/articles/s41...
SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma - Cell Death & Differentiation
Cell Death & Differentiation - SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma
nature.com
Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis” BDNF/TRKB axis as a viable #TherapeuticTarget in #TNBC ⤵️ www.nature.com/articles/s41...
Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis - Cell Death & Differentiation
Cell Death & Differentiation - Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis
nature.com
“SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice” This study positions SETD7 as a novel negative regulator of iWAT thermogenesis ⤵️ www.nature.com/articles/s41...
SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice - Cell Death & Differentiation
Cell Death & Differentiation - SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice
nature.com
“Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation” Read how this kinase may serve as a molecular gatekeeper against #TumorProgression by promoting #CellDeath ⤵️ www.nature.com/articles/s41...
Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation - Cell Death & Differentiation
Cell Death & Differentiation - Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation
nature.com
“Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy” This review on #Ferroptosis offers insights into #PrecisionOncology strategies to overcome #TherapeuticResistance and enhance clinical outcomes ⤵️ www.nature.com/articles/s41...
Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy - Cell Death & Disease
Cell Death & Disease - Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy
nature.com
“Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer” A new research from Prof Jochen's lab is now online in CDD ⤵️ www.nature.com/articles/s41... (1/5)
Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer - Cell Death & Differentiation
Cell Death & Differentiation - Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer
nature.com
🎗️Sarcoma Awareness Month🎗️ Access our updated collection of Sarcoma-related research papers in: Cell Death & Disease nature.com/subjects/sar... Cell Death Discovery nature.com/subjects/sar... #Sarcoma #SarcomaAwarenessMonth #CancerResearch
“Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson’s disease” Explore how ATP6V0C overexpression can restore lysosomal function in #ParkinsonDisease ⤵️ www.nature.com/articles/s41...
“Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis” These findings position FAPs as amplifiers of #inflammation in Idiopathic inflammatory myopathies ⤵️ www.nature.com/articles/s41...
“ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution” ZFP36L1:ZFP36L2 #RNAbindingProteins pair: a critical determinant of the TEC #microenvironment’s integrity ⤵️ www.nature.com/articles/s41...
“Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration” A macrophage-dependent pathway that links #Efferocytosis to #VascularRegeneration ⤵️ www.nature.com/articles/s41...
Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration - Cell Death & Differentiation
Cell Death & Differentiation - Efferocytosis enhances macrophage pro-angiogenic functions for bone marrow regeneration
nature.com
“Fas acts as a T cell co-stimulatory receptor via both death domain-independent and -dependent mechanisms” Fas is not just about #CellDeath but a key player in #Tcells activation ⤵️ www.nature.com/articles/s41...
“Adipocyte-specific ablation of Gadd45b exacerbates obesity-associated cellular senescence and metabolic disorders via Fgf1b promoter hypermethylation” A mechanistic link between #obesity, #DNAmethylation, and #metabolism ⤵️ www.nature.com/articles/s41...
Mechanism identified in targeted therapy for metastatic #colorectalcancer ⤵️ Researchers at #MedUniVienna have shown that the EGFR receptor influences #immunecells in the #tumour microenvironment – and thus the body’s own defence against #metastaticcolorectalcancer. ⬇️ 📰 @cddpress.bsky.social
Colorectal cancer research is placing greater emphasis on immune cells
More about the study!
meduniwien.ac.at
