IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. vist.ly/5dp9p

Altered B-cell homeostasis and elevated IL10/TNFA expression in #CIDP suggest chronic humoral immune activation. Immune markers also correlated with nerve fiber loss and disability, highlighting potential biomarkers of disease activity. vist.ly/5d68e #Neurology #Neuroimmunology

Disease activity in chronic inflammatory demyelinating polyneuropathy: association between circulating B-cell subsets, cytokine levels, and clinical outcomes

B-cell homeostasis is significantly altered in chronic inflammatory demyelinating polyneuropathy (CIDP) and is not reversed by immunomodulatory treatments.

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T-cell integrins play a central role in immune cell trafficking, tissue retention, and inflammation. This review examines how targeting these molecules is shaping treatments for autoimmune and inflammatory diseases, including IBD, multiple sclerosis, and psoriasis. 🔗 vist.ly/5cycj

Targeting T-cell integrins in autoimmune and inflammatory diseases

Activated T cells bind to the endothelium using activated integrins as part of the multi-step process of extravasation. The expression of specific repertoi

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🔬 New research suggests that individuals exposed to Mycobacterium tuberculosis without developing active disease have stronger IgA and IgG antibody responses than TB patients. High salivary IgA levels also point to an important role for mucosal immunity in TB protection. vist.ly/5cuf7

🔬 New evidence suggests β-tubulin 5 (TBB5) is unlikely to be the pANCA target in primary sclerosing cholangitis (PSC), narrowing the search for the underlying autoantigen. 📖 vist.ly/5c73w #Immunology #Autoimmunity

🧬 New insight into rituximab resistance: CD40L and IL-4 shield B cells from NK cell-mediated killing via the HLA-E/NKG2A and HLA/KIR inhibitory pathways. Targeting these checkpoints could enhance B-cell depletion in autoimmune disease. 📖 vist.ly/5c37t

🧬 Targeting TIM pathways in RA? In a murine arthritis model, blockade of TIM-1 or TIM-3 reduced disease severity, inflammatory cytokines (IL-6, IL-17A, TNF-α), and joint damage, highlighting both receptors as promising therapeutic targets in rheumatoid arthritis. 📖 vist.ly/5btfj

Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ. Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target. 📄vist.ly/5bipi

Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis. 📄 vist.ly/5ba6v

Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 vist.ly/5b74h

This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target. 📄 vist.ly/5aser

🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 vist.ly/5ag5y

Type 1 Diabetes arises from a loss of immune tolerance. Our article explores how hyperglycaemia and immunometabolic changes may influence regulatory T cell function, offering new insights into disease mechanisms and therapeutic opportunities. 🔗 vist.ly/5adnr

IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. vist.ly/59xti

🔬 LPA drives macrophages toward an anti-inflammatory M2-like phenotype via LPAR1, reducing inflammatory signals and promoting oxidative metabolism, highlighting a potential target for inflammatory and autoimmune diseases. 🔗 vist.ly/59uqq #Immunology #Macrophages

Lysophosphatidic acid regulates macrophage polarization via LPAR1 by suppressing inflammatory responses and promoting M2-like characteristics

Lysophosphatidic acid (LPA) is a crucial bioactive lipid mediator involved in various physiological processes. However, its role in macrophage polarisation

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IFNγ from activated CD4⁺ T cells plays a key role in driving lupus by promoting B‑cell differentiation and autoantibody production. Mice lacking IFNγ showed reduced symptoms, highlighting these cells as a potential therapeutic target. vist.ly/59qty #Immunology #SLE #LupusResearch

Phase 3 vaccine trials are moving beyond traditional designs, with adaptive methods and modern analytics helping to improve efficiency and decision-making in vaccine research. 📖 vist.ly/595z4 #Vaccines #ClinicalTrials #Biostatistics

Past, present, and future of Phase 3 vaccine trial design: rethinking statistics for the 21st century

This paper provides an overview of the evolution of Phase 3 vaccine trial design and statistical analysis methods from traditional to more innovative conte

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🔬 Organoids are transforming immunology research. By incorporating immune and microbial cells, these increasingly complex 3D models are helping uncover new immune–epithelial interactions, disease mechanisms, and therapeutic opportunities. 🔗 vist.ly/593kk

Expanding organoid complexity to advance immunology research

Historically, immunological research, especially when involving human cells, has relied heavily on the use of in vitro cultures. While this has led to coun

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🚀 Excited to announce the Immunometabolism Section in @ceijournal.bsky.social led by Dr Lizzy Rosser (UCL) A dedicated home for cutting-edge research exploring how metabolism shapes immune function in health and disease. Learn more: vist.ly/58wxd #Immunometabolism #Immunology

Discover the benefits available when peer reviewing for the @britsocimm.bsky.social journals, including a chance to work with immunology experts to advance research. 🔗 oxford.ly/4fWq6kZ #ImmunoSky | @ceijournal.bsky.social | @imtadvances.bsky.social | @discovimmunol.bsky.social

🩸 Could blood-based immune markers help monitor treatment response in eosinophilic oesophagitis (EoE)? Using CyTOF, researchers identified immune cell changes following orodispersible budesonide treatment, including shifts in T cells and eosinophil populations. 🔗 vist.ly/588me

Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide

(A) Minimum spanning tree of eosinophil populations present in the blood of 10 patients with EoE before and after treatment with orodispersible budesonide

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Primary humoral immunodeficiencies (sIgAD, CVID, THI) remain complex, overlapping conditions with diagnostic challenges & evolving management. The field continues moving toward more personalised approaches to care. 🔬 vist.ly/584aq #Immunology #RareDiseases

Clinical and experimental treatment of primary humoral immunodeficiencies

Comparison of the most common forms of primary antibody deficiencies: THI, CVID, and sIgAD, including main characteristic features and the possibility of p

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Huge congratulations to Prof Stephen Jolles on his OBE in the King’s Birthday Honours for services to immunology & rare diseases 👏 A leader in the field and valued CEI editorial board member! 🎉 #Immunology

🔬 New for #DiabetesWeek2026: Insulin or proinsulin, what’s the first autoimmune target in #T1D? Study shows similar potency for both, highlighting heterogeneity in early immune responses & age/sex differences. 🔗 vist.ly/57irp #DiabetesResearch #Immunology

Heterogeneity between insulin and proinsulin in the potency for insulin autoantibodies in newly diagnosed type 1 diabetes children

Displacement of IAA binding by increasing log10 concentrations (0–100 nM) of unlabeled insulin (green; actual concentrations 0–86 nM) or proinsulin (purple

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📢 Explore the #FOCIS2026 Virtual Issue A curated virtual issue from Clinical & Experimental Immunology highlighting advances in immune microenvironments, immune evasion, and bioengineering 🧬 Discover the research shaping translational immunology: vist.ly/57h5j #Immunology

Exosomes are emerging as key regulators of immune communication, shaping responses in cancer, infection, and immunotherapy 🧬 Featured in the #FOCIS2026 Virtual Issue, this review explores their roles in immune signalling, evasion, and therapeutic potential 🔗 vist.ly/57eab #Immunology

Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies

Exosomes are nanoscale extracellular vesicles that integrate molecular cues to modulate immune responses across cancer and infection contexts. This review

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NK cell receptors play a key role in viral immunity, shaping activation, exhaustion, and immune evasion pathways 🧬 Featured in our #FOCIS2026 Virtual Issue, this review explores how viruses including SARS-CoV-2 modulate NK cell responses 🔗 vist.ly/579eq #Immunology #InfectiousDisease

NK-cell receptor modulation in viral infections

This review summarizes recent knowledge on NK cell receptor alterations mediated by viral infections, along with the mechanisms responsible for this modula

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Part of our Clinical & Experimental Immunology FOCIS 2026 Virtual Issue: New research on thymic myoid cells reveals their role in shaping immune microenvironments and driving tumour-associated myasthenia gravis. vist.ly/575h9 #FOCIS2026 #Autoimmunity

Deletion of thymic myoid cells regulates the thymic microenvironment involved in the progression of tumor-associated myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease commonly associated with immune disorders in thymoma. The role of thymus myoid cells (TMCs) in the pathogen

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Environmental pollution may worsen asthma 🌍 This research shows that 3-methyl-4-nitrophenol (MNP) promotes ER stress in airway epithelial cells, driving oncostatin M → macrophage TNF-α → increased allergic inflammation. 🔗 vist.ly/56ra4 #Immunology #Asthma #AirPollution

Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation

The objective of this study is to elucidate the role of 3-methyl-4-nitrophenol (MNP), an environmental pollutant, in asthma exacerbation. In this study, an

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Long non-coding RNAs are emerging as key drivers of neuroimmune interactions in oral cancer, shaping immune evasion and nerve invasion and pointing to new therapeutic targets 🧬 🔗 vist.ly/55mgj #Immunology #CancerResearch #Neuroimmunology

LncRNAs at the frontline of neuroimmune crosstalk in oral cancer

This review examines the current role of long non-coding RNAs (lncRNAs) in the neuroimmune crosstalk in oral squamous cell carcinoma and specifically their

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