SAVE THE DATE! The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026. Exciting line up of talks and an amazing location! Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro. Registration open soon.

Exciting @biorxivpreprint.bsky.social by the groups of @pjcossar.bsky.social and @alessiociulli.bsky.social. They use a molecular glue between 14-3-3 and an intrinsically disordered domain of ERα to develop a molecular glue-based PROTAC recruiting VHL. doi.org/10.1101/2025... #TPD #ChemSky #ChemBio

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design

Proteins lacking defined ligandable pockets remain challenging drug targets. Here, we develop a molecular glue-based PROTAC (MGPROTACs) approach that chemically conjugates a molecular glue stabilizer ...

doi.org

Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design www.biorxiv.org/content/10.1101/2025.11.17.688825v1 #cryoEM

From degradation to stabilisation! Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex. 🔗https://www.biorxiv.org/content/10.1101/2025.11.18.689129v1.full.pdf

House of VHL meets house of 14-3-3 🤝 Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design” 🔗https://www.biorxiv.org/content/10.1101/2025.11.17.688825v1

After the Krios I's 10-year birthday earlier this year (full story can be found here: lnkd.in/eCKF3vBF), it was awesome to visit the eBIC facilities at @diamondlightsource.bsky.social and see that the epic party hat still lives on 🥳

My first 🦋 post! Awesome view over the haar (fog) over the river Tay yesterday afternoon, on the train heading down to @diamondlightsource.bsky.social for the CCP-EM Icknield workshop - looking forward to a great week of cryo-EM data processing and model building 🔬