Cohesin and CTCF jointly fold genomes, but why do their depletion affect few genes, with minimal overlap? Do all regulated genes require looping and enhancers? In our new paper in Nature Genetics we disentangle their functions in gene regulation. www.nature.com/articles/s41...

Do enhancers often skip active genes? Our other recent preprint revises current models, that enhancers frequently and by design skip active genes to activate distal targets. Instead simple rules can predict enhancer and GWAS targets. www.biorxiv.org/content/10.1...

Mammalian enhancers and GWASs act proximally and seldom skip active genes

Enhancers play a critical role in regulating transcription. Nearly 90% of human genetic variants identified in genome-wide association studies (GWAS) are located in distal regions, underscoring the im...

biorxiv.org

How do cohesin and CTCF control gene expression and what are their links to enhancers? Our new preprint unravels their shared and unique roles: from precise enhancer targeting to direct transcriptional activator functions of CTCF! #Genomics #CTCF #Cohesin www.biorxiv.org/content/10.1...

A unified model of gene expression control by cohesin and CTCF

Cohesin and CTCF fold vertebrate genomes into loops and topologically associating domains (TADs). The genome folding by cohesin and CTCF is considered crucial for enhancer-promoter communication and g...

biorxiv.org