Our new paper published online early in Microbiome On long-term impact of #CFTRmodulators on the lung #microbiome across adults living with #cysticfibrosis from centres in UK, USA, and Canada @hgavillet.bsky.social link.springer.com/article/10.1...

Remodelling of cystic fibrosis respiratory microbiota in response to extended elexacaftor–tezacaftor–ivacaftor therapy - Microbiome

Background Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of th...

link.springer.com

Another new paper. This time a mini review on the gut-lung axis in #CF just published in the Journal of #CysticFibrosis www.sciencedirect.com/science/arti...

Towards a gut-lung axis role in pwCF on CFTR modulators: rationale, clinical evidence and perspectives

Recent data support the existence of a “gut-lung axis” (GLA), yet it’s role in chronic respiratory diseases, like cystic fibrosis (CF), is under inves…

sciencedirect.com

New paper focusing on the oral microbiome as part of a new collaboration with Chris Nile at Newcastle University School of Dental Sciences onlinelibrary.wiley.com/doi/10.1002/...

Investigations into the aetiopathogenesis of orofacial granulomatosis using multiple omics technologies reveal a potential role for B cells

Click on the article title to read more.

onlinelibrary.wiley.com

Our mini-review - The gut microbiome: Recent findings and future opportunities in #CF - now out in the Journal of #CysticFibrosis The gut microbiome: Recent findings and future opportunities in cystic... www.sciencedirect.com/science/arti...

The gut microbiome: Recent findings and future opportunities in cystic fibrosis

The gut microbiome is a key modulator of human health throughout life, from infancy to old age. Within this relatively young field, microbiome charact…

sciencedirect.com

PhD studentship @manmetuni.bsky.social applications now open! Interested in the mechanisms of microbial invasion in respiratory disease? This @cysticfibrosis.org.uk match funded PhD might be for you! www.findaphd.com/phds/project...

Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University on FindAPhD.com

PhD Project - Interrogating microbiomes and metabolomes during P. aeruginosa infiltration and colonisation in CF respiratory tract infection at Manchester Metropolitan University, listed on FindAPhD.c...

findaphd.com

I have an open BBSRC PhD position in my lab at @northumbriauni.bsky.social to start Oct 2026 This exciting project will focus on the Resistance, resilience, & redundancy in the human gut microbiome This is part in collaboration with the fantastic @stewartlab.bsky.social Project details ⤵️ 1/2

Excited to share our new work comparing the impact of long-term CFTR modulator therapy on #CF lung pathogens & respiratory microbiome within a large, multi-centre & multi-national cohort of adults living with #cysticfibrosis www.medrxiv.org/content/10.1...

Remodelling of cystic fibrosis respiratory microbiota in response to extended Elexacaftor/Tezacaftor/Ivacaftor therapy

Background: Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of t...

medrxiv.org

Our new paper out on influence of chronic pancreatitis on the gut microbiome. What makes this more special is it is Ryan Marsh’s 1st as corresponding author. doi.org/10.1186/s128...

Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants - BMC Gastroenterology

Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal micr...

doi.org

Got an invite to review a paper on Friday night from a well-known clinical journal. Followed by an abrupt & demanding reminder early Sunday morning I wonder why it is increasingly difficult to get willing quality reviewers these days?🤷‍♂️ Unsurprisingly I declined the offer to review

Great to be in Queen's Univerity Belfast for the GRAMPUS-CF conference This @cysticfibrosis.org.uk funded Strategic Research Centre is exploring ‘clusters’ of gut symptoms in #CysticFibrosis to see if they have common causes More details on GRAMPUS #CF ⬇️ www.grampus-cf.org

GRAMPUS-CF | Discover Gut Insights Today

Join the GRAMPUS-CF study to explore gut symptoms in cystic fibrosis and help develop personalized treatments. Enroll online or via CF centers.

grampus-cf.org

Our new paper out in Microbiology Spectrum: Nontuberculous mycobacteria remodel lung microbiota in #cysticfibrosis associated respiratory infections Driven by @dwrivett.bsky.social and Michelle Hardman. From Michelle’s @cysticfibrosis.org.uk funded PhD work #CF doi.org/10.1128/spec...

Nontuberculous mycobacteria remodel lung microbiota in cystic fibrosis-associated respiratory infections | Microbiology Spectrum

The influence of NTM infection in pwCF is still debated, and the extent of their contribution to mortality and morbidity is still questioned. Findings in this study highlight a link between the presen...

doi.org

Our new paper out now in Microbiome: Species turnover within #cysticfibrosis lung microbiota is indicative of acute pulmonary exacerbation onset doi.org/10.1186/s401... #CF #microbiomeecology #microbiome

Species turnover within cystic fibrosis lung microbiota is indicative of acute pulmonary exacerbation onset - Microbiome

Background Acute pulmonary exacerbations (PEx) are associated with increased morbidity and earlier mortality for people living with cystic fibrosis (pwCF). The most common causes of PEx in CF are by b...

doi.org

Our very own @hgavillet.bsky.social giving her talk today at #ECFS2025 in Milan on the impact of #kaftrio CFTR modulator therapy on the #CysticFibrosis lung microbiome Our KAFPATH-CF study is a multi-national (UK, USA, & Canada) multi-centre long-term longitudinal study of adults with #CF

Our very own Ryan Marsh presenting his #CysticFibrosis gut microbiome & metabolomics data at the #ECFS2025 meeting in Milan This is part of the wider @cysticfibrosis.org.uk funded GRAMPUS-CF strategic research centre 👀 here for more details www.grampus-cf.org

Fascinating and important study. May well be transformative in treatment of stubborn chronic lung infections such as by Pseudomonas aeruginosa in #cysticfibrosis and beyond rdcu.be/ekdWf

Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis

Nature Medicine - A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of...

rdcu.be

Ryan Marsh from my group giving a great talk on our initial #CysticFibrosis gut microbiome findings from our GRAMPUS-CF strategic research centre @ the #ECFS Basic Science meeting in Italy

Final day of the European Young Investigators Meeting #EYIM for #cysticfibrosis in Paris Delighted to be supporting as a ‘senior’ scientist The #EYIM2025 presentations have been outstanding The talent displayed at this meeting bodes well for future of #CF research

Helen giving her Rising Star talk @ the #RTI2025 meeting in Glasgow ⭐️ @hgavillet.bsky.social #CF #CysticFibrosis

What a a great place to meet & talk on new #cysticfibrosis respiratory & gut studies with the lovely folk from Manchester Paediatric #CF centre Feeling genuinely inspired Whitworth Art Gallery - Manchester

Helen a PDRA in my lab @northumbriauni.bsky.social has been recognised with the Rising Star award @ the upcoming Respiratory Infections Forum #RTI2025. Well done Helen, what a great recognition! rti-forum.org/2025/ @lenagroup4resp.bsky.social

Ah, the glamour of international travel. This red eye flight is so early I had to get up half an hour before I went to bed.

Microbiome ecology approaches reveal bacterial interactions underpin worse lung function in #CysticFibrosis #CF Lung infections are not caused by 1 pathogen in isolation but instead by interplay of complex lung microbiota of many different microbes interacting with each other & the lung environment

Chris van der Gast@chrisvandergast.bsky.social · 2y ago

Fantastic to see our latest paper now published in mBio on how species interactions impact #cysticfibrosis respiratory infections ⤵️ #microbiomeecology #cf Lovely way to finish the week doi.org/10.1128/mbio...

Fantastic to see our latest paper now published in mBio on how species interactions impact #cysticfibrosis respiratory infections ⤵️ #microbiomeecology #cf Lovely way to finish the week doi.org/10.1128/mbio...

Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections | mBio

Research studies have repeatedly demonstrated that chronic lung infection in cystic fibrosis is polymicrobial and consequently does not adhere to the single microbe-based Koch’s postulates. Despite th...

doi.org

After editing, this very short letter to New Scientist is even shorter now. But I think it gets the point across! @faecalmatters.bsky.social

Our latest paper now published in Journal of #cysticfibrosis Impact of extended Kaftrio therapy on the gut #microbiome in #cf Great work from Ryan Marsh (not yet in this place) sciencedirect.com/science/arti...

Impact of extended Elexacaftor/Tezacaftor/Ivacaftor therapy on the gut microbiome in cystic fibrosis

There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator therapies upon the gut microbiom…

sciencedirect.com