For the first time, we hosted a CNRS Unusual Visits event: 290 applications → 24 visitors→ A tremendous enthusiasm!! Highlights included immune system talks & hands-on workshops on skin, cholesterol, IgE, and DNA extraction.

CNRS Provence et Corse@cnrs-dr12.bsky.social · 10mo ago

🧫 Immersion totale au @ciml.bsky.social ! Dans les labos, les scientifiques dévoilent comment les êtres vivants traquent et neutralisent virus et bactéries 🦠 Un voyage fascinant au cœur des défenses naturelles 💥 #FDS2025 #FDSSud #CNRSinsolite @univ-amu.fr @insermpacacorse.bsky.social @inserm.fr

🔬 A look back at the 2025 Science Festival in CIML! On Thursday 9 October, we had the pleasure of opening the doors of our laboratories to middle and high school students as part of the 2025 Science Festival. A day rich in discoveries and exchanges! #FêteDeLaScience #FDS2025

🔬 The CIML is proud to be an academic partner of the 11th edition of #MiFoBio2025, the Functional Microscopy in Biology school organized by @gdrimabio.bsky.social taking place from October 10–17, 2025. The CIML Imaging Platform and researchers will be sharing our expertise in immune system imaging.

A new study led by Sandrine Henri is out now in OncoImmunology. Authors characterized the prostate's immune landscape in healthy inidviduals and during cancer progression. Congratulations to 1st author Despoina Pervizou and all collaborators.

Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression

The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis...

tandfonline.com

A new study led by Elena Tomasello & Marc Dalod is out now in @natimmunol.nature.com. Through the generation of a novel system lacking plasmacytoid DCs, authors show that pDCs are dispensable or deleterious in respiratory viral infections. Congrats to 1st author Clemence Ngo and all collaborators!

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections - Nature Immunology

Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

nature.com

Today we had the great honor to welcome Dr Michela Locci from the University of Pennsylvania in our CIML seminar series. Michela gave an outstanding seminar entitled "Defense decoded: how mRNA vaccines train germinal center responses" and had great exchange with CIML scientists.

It was a pleasure to have Ang Cui presenting her work at CIML.

CENTURI - Turing Centre for Living Systems@centuri-ls.bsky.social · 10mo ago

Ang Cui, from @harvardmed.bsky.social , invited by @ciml.bsky.social and CENTURI is now holding her talk "Dictionary of immune responses to cytokines at single-celle resolution"!

Today we had the great honor to welcome Dr Florent Ginhoux from Gustave Roussy Institute in our CIML seminar series. Florent gave an outstanding seminar entitled "Harnessing Tumor Macrophage Heterogeneity" and had great exchange with CIML scientists.

Today we had the great honor to welcome Dr Megan MacLeod from the University of Glasgow School of Infection and Immunity. Megan gave a great talk on"Different faces of immune memory in the lung following influenza virus infection" and had great exchange with CIML scientists. Thanks for visiting us!

Today we had the great honor to welcome Dr Ed Roberts from the Cancer Research UK-Scotland Institute @cruk-si.bsky.social. Ed gave a great talk on"Time dependent impact of viral infection on lung tumour development" and had great exchange with CIML scientists. Thanks Ed for visiting us!

Today we had the great honor to welcome Dr Francesca Granucci from the University of Milano-Bicocca in our CIML seminar series. Francesca gave an outstanding seminar entitled "Microbial adhesion promotes mechanotransduction to initiate innate immunity" and had great exchange with CIML scientists.

🗞️ La Provence newspaper dedicated an article to Réjane Rua's work and career on August 6th, highlighting her expertise and remarkable studies at CIML. Check here:

À Marseille, la scientifique Réjane Rua rêve de faire avancer la recherche contre Alzheimer

À Marseille, la scientifique Réjane Rua rêve de faire avancer la recherche contre Alzheimer

laprovence.com

Big congratulations to Achille Broggi @achillebro.bsky.social, team leader at CIML, who has been awarded the 2025 CNRS Bronze Medal! This distinction honors his research on innate immunity, particularly his discoveries on the role of interferons in tissue protection and repair.

The CIML mourns the loss of its founding father, Michel Fougereau. In 1976, he founded our institute to bring immunology researchers in France together on one site. Generations of immunologists were shaped by what he built. His legacy lives on in the curiosity and collaboration that define CIML.

Last week we had the great honor to welcome Dr Maria Rescigno from Humanitas Research Hospital in our 2025 CIML seminar series. Maria gave an outstanding seminar on "The microbiota in pregnancy outcome and risk of sepsis in the newborn" and had lots of great exchange with CIML scientists.

Last week we had the great honor to welcome Dr Nuria Martínez-Martín from Severo Ochoa Molecular Biology Centre in our 2025 CIML seminar series. Nuria gave a brillant seminar on "Mitochondria as Gatekeepers of B Cell Function: Internal Regulators and External Gifts" Thanks Nuria for visiting !

Yesterday, we had the pleasure to welcome Dr. Vera Pancaldi from Centre de Recherche en Cancérologie de Toulouse in our CIML seminar series. Vera gave a brillant seminar on "Data-driven mathematical models for simulating the tumour microenvironment" Thanks for visiting @verapancaldi.bsky.social !

Last week we had the great honor to welcome Pr. Ping-Chih Ho from University of Lausanne and Ludwig Cancer Research in our 2025 CIML seminar series. Ping-Chih gave a brillant seminar on "Mitochondria-tailored T cell dysfunction and opportunity for cancer immunotherapy" Thanks for visiting !

Last week we had the great honor to welcome Pr. Tal Arnon from University of Oxford in our 2025 CIML seminar series. Tal gave an outstanding seminar on "Humoral immunity in the infected lung" and had lots of great exchange with CIML scientists. Thanks for visiting !

Check this last paper from the Malissen's lab👇. A gain-of-function CARMIL2 variant can substitute for CD28 costimulation, enabling T cells to bypass PD-1 and CTLA-4 checkpoints. This discovery revisits the architecture of the CD28 costimulatory pathway and opens avenues for next-gen immunotherapies.

Journal of Experimental Medicine@jem.org · last yr.

Zhang, Celis-Gutierrez, Malissen, Malissen et al. @ciml.bsky.social‬ demonstrate that the expression of a mutated CARMIL2 protein in CD28-deficient mice induces most of the developmental and functional consequences known to result from CD28 costimulation rupress.org/jem/article/...

🦠 Check the last study from the team of Philippe Pierre in PNAS @pnas.org. The authors show how a bacterial toxin can hijack our cells’ stress response to trigger immune signals linked to inflammation and infection. Congratulations to all authors!

Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation | PNAS

We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononucle...

pnas.org

Last week we had the great honor to welcome Dr. Eliane Piaggio from Institut Curie in our 2025 CIML seminar series. Eliane gave an interesting seminar on "Single-Cell Treg Profiling: New Cancer Therapies and Insights into Tumor-Treg Biology" and had great exchanges with CIML scientists.

🧠🦠 Check this Review written by the team of Sophie Ugolini @ugolinis.bsky.social on how sensory neurons modulate immune responses. Just out in Immunity @cp-immunity.bsky.social.

Role of specialized sensory neuron subtypes in modulating peripheral immune responses

The immune and sensory nervous systems work in concert to defend against threats and maintain homeostasis. In this issue of Immunity, Ugolini and colleagues review how immune signals activate speciali...

cell.com

🔬 🦠 Check this great scientific meeting organized by Carolyn King and CIML's team leader Mauro Gaya. @immunologyking.bsky.social @maurogaya.bsky.social

Mauro Gaya@maurogaya.bsky.social · last yr.

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues

🧠🛡️ CIML celebrates the International Day of Immunology 2025: When Brain Meets Immunity. This year, we spotlight two Inserm researchers whose research is transforming our understanding of how the nervous and immune systems interact, paving the way for new therapies for neurological diseases.

🎉 We're thrilled to share that Dr. Anaïs Rogier, trained at CIML in Sophie Ugolini’s team, has received the Aix-Marseille University Thesis Award for her outstanding work on neuro-immune regulation during viral infections. Bravo Anaïs! 🧠🦠

In a study led by Jean-Pierre Gorvel and Sylvie Mémet, CIML researchers found that SLAMF receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria. Congrats to 1st author Joaquin Pellegrini and collaborators. www.jci.org/articles/vie... @jclinical-invest.bsky.social

We are proud to announce that Prof. Eric Vivier @ericvivier.bsky.social, team leader at CIML and former director (2008–2017), has been awarded the prestigious Léopold Griffuel Prize for "Translational and Clinical Research" by the ARC Foundation for Cancer Research. @univ-amu.fr @inserm.fr @cnrs.fr

Today, we had the pleasure of welcoming Dr. Iñaki Martin Subero from Fundació de Recerca Clínic Barcelona in Spain as part of the 2025 CIML seminar series. Iñaki gave an incredible seminar: “An epigenetic journey to the origin, pathogenesis and evolution of chronic lymphocytic leukemia”.

Yesterday we organized the CIML Scientific Day dedicated to "Immunology Meets Oncology" The day featured outstanding presentations on the intersection between immunology and cancer research from Bruno Quesnel, Pierre Milpied, Nathalie Auphan-Anezin, Eric Vivier, Carole Siret, and Rafael Argüello.