How does catalysis emerge from non-catalytic domains? In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead. A striking case of catalysis evolving from binding.
Molecular Biology and Evolution@molbioevol.bsky.social · 10mo ago@claudele.bsky.social et al. studied the fundamental question of how enzymatic activity emerges by focusing on type B dihydrofolate reductases, suggesting DfrB domains evolved rudimentary catalysis from a binding capacity. 🔗 doi.org/10.1093/molbev/msaf215 #evobio #molbio
