Clemens Schulte
@clemensschulte.bsky.social
MSc. Biochemistry, Dr. rer. nat. | former grad student @hmariclab Peptides & Biophysics
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco
Our eSylites are on the cover of the current #JACS issue! Check it out 👇
Journal of the American Chemical Society (JACS)@jacs.acspublications.org · last yr.On the cover of this week's #JACS: "eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses" Read it here 🔗 buff.ly/tunBPI2 #ChemSky
Make sure not to miss our latest paper out now in #JACS - presenting eSylites - small, peptide-based probes for precise mapping of neurons, etc.! Microscale thermophoresis (MST) played a huge part in optimizing the probes structure and sequence for binding affinity. #ChemicalBiology #Synapse
Maric Lab@hmariclab.bsky.social · last yr.🚀 Excited to share our latest work in #JACS on eSylites! —Synthetic, high-affinity #ChemicalBiology probes for #SuperResolution #Synapse visualization & precise mapping in neurons and brain slices—without the need for antibodies, tags, or transfection! 📢 Read more: pubs.acs.org/doi/10.1021/...
🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!
Bettina Böttcher@boettchercryoem.bsky.social · 2y agoOur joined effort with the the Maric Lab @hmariclab.bsky.social @uniwuerzburg.bsky.social on how to aggregate capsids of Hepatitis B virus inside cells is now out in Elife doi.org/10.7554/eLif... . #cryoEM 🧪❄️🔬
#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky
Super excited to finally see the final version of this paper online 😁 Great team effort combining biophysics and #CryoEM for development of HepB aggregating compounds! Huge thx to everyone involved!
Maric Lab@hmariclab.bsky.social · 2y ago🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!
