🍟 When a cannabinoid receptor was removed from the gut lining, mice no longer preferred a high-fat, high-sugar diet. Dr. Nicholas DiPatrizio explains what this reveals about food choice. 🎧 https://f.mtr.cool/uitcdffjkp #High5Podcast
Center for Medicinal Cannabis Research (CMCR @ UCSD)
@cmcr-ucsd.bsky.social
Established in 2000, the Center for Medicinal Cannabis Research at UCSD I has been at the forefront of advancing science and policy relating to the potential clinical benefits, and limitations, of cannabis and cannabinoids as medicine. www.cmcr.ucsd.edu.
📊 New study: Adult cannabis use in California remained largely stable from 2017–2024, but combustible use declined while edible use increased. Observational study—cannot infer causality. ➡️ Stable use, shifting methods 🔗 https://f.mtr.cool/yoqmefnuaq #CannabisResearch
🔬 How can scientists pinpoint the gut’s role in overeating? Dr. Nicholas DiPatrizio explains how organ-specific mouse models reveal what cannabinoid receptors do in the intestinal lining. 🎧 https://f.mtr.cool/qdwkloxyof #High5Podcast #GutBrainAxis
🍔 Built for feast or famine, the endocannabinoid system can push us to seek and eat more high-energy food—an ancient survival advantage with modern metabolic consequences. 🎧 https://f.mtr.cool/xhompbelnt #High5Podcast #ObesityResearch
🧠 Phase II trial found that very low-dose THC–CBD extract was associated with a higher MMSE score than placebo after 26 weeks in Alzheimer disease–associated dementia. No significant differences in adverse events. Results: preliminary. 🔗 https://f.mtr.cool/avrlxpvbsq #CannabisResearch
🧠 What connects nutrient sensing in the gut to the brain? Dr. Nicholas DiPatrizio explains the endocannabinoid system’s role in gut movement, absorption, and signaling. 🎧 https://f.mtr.cool/hhxruzvari #High5Podcast #GutHealth
New research from CMCR validated an LC-MS/MS method for measuring 64 pesticides in cannabis-derived hemp oil. ➡️ Key takeaway: it produced highly linear, accurate and reproducible measurements. 🔗 https://f.mtr.cool/uldqrkpezf #CannabisResearch
🩺 Survey of 879 U.S. healthcare professionals: 74% were open to recommending medical cannabis, but objective knowledge scores were low. ➡️ Authors call for structured clinical training. 🔗 https://f.mtr.cool/nnumxeuliq #CannabisResearch
🧠 Phase 2 trial in Alzheimer’s disease dementia: daily low-dose THC-CBD extract for 26 weeks was linked to higher Mini-Mental State Exam scores vs placebo. ➡️ Larger, longer trials are needed. 🔗 https://f.mtr.cool/tyauzcdpxe #CannabisResearch
🌿 Missed the July CMCR Investigators’ Meeting? 🎙️ Watch Guido Frank, M.D., discuss how CBD may improve anxiety, weight restoration, and eating disorder symptoms in anorexia nervosa. 🧠🔬 🎥 https://f.mtr.cool/gwjgltjprb #CMCR #CBD #CannabisResearch
💨 Study of vaporised cannabis found THC+CBD produced higher THC and THC-metabolite plasma levels than THC alone. ➡️ No strong evidence of age-related differences. 🔗 https://f.mtr.cool/jcyyscfllw #CannabisResearch
❤️ TriNetX cohort study: AF incidence was 1.8% in the cannabis cohort vs 2.0% in the tobacco cohort, a small difference. ➡️ Retrospective ICD-10 data cannot show causality. 🔗 https://f.mtr.cool/ukregjcypi #CannabisResearch
🌿 Missed the July CMCR Investigators’ Meeting? 🎙️ Watch Guido Frank, M.D., discuss how CBD may improve anxiety, weight restoration, and eating disorder symptoms in anorexia nervosa. 🧠🔬 🎥 https://f.mtr.cool/jfhixvatge #CMCR #CBD #CannabisResearch
⚠️ U.S. survey study: multi-modal cannabis use had the highest cannabis use disorder prevalence at 40.5%, vs 4.4% for oral/mucosal-only use. ➡️ Cross-sectional data cannot show causality. 🔗 https://f.mtr.cool/cjmirxecdw #CannabisResearch
🗽 NY medical cannabis surveys found high product costs and distance to dispensaries were central barriers to program participation. ➡️ 49% said they could not afford enough product to manage symptoms. 🔗 https://f.mtr.cool/sfbkgptwln #CannabisResearch
🧠 One-year Australian observational study of 103 paediatric epilepsy patients: CBD was associated with sustained improvements among continuers, but 46% discontinued. ➡️ More research needed to identify likely responders. 🔗 https://f.mtr.cool/hqmvpmlkce #CannabisResearch
🧠 In obese mice, peripheral CB1 receptor blockade reduced food intake and shifted metabolism toward fatty acid oxidation. ➡️ Effects did not depend fully on the gut–brain vagal axis. 🔗 https://f.mtr.cool/eakpchhvvl #CannabisResearch
🧠 CARDIA cohort MRI study: cumulative cannabis exposure over 30 years was not associated with hippocampal volume, integrity, or blood flow in middle age. ➡️ Observational findings; causality cannot be inferred. 🔗 https://f.mtr.cool/rrrtqvsbft #CannabisResearch
🩺 In a 29-patient observational study, medical cannabis use was linked with lower opioid use, reduced pain scores, and improved physical functioning over 5 months. ➡️ Causality cannot be inferred. 🔗 https://f.mtr.cool/ltkjblscst #CannabisResearch
🧪 In a 24-adult pilot trial, 1:1 THC:CBD oil was feasible, well tolerated, and showed preliminary signals for pain, sleep, and fibromyalgia impact. ➡️ Larger trials are needed to confirm efficacy. 🔗 https://f.mtr.cool/slytklnsxe #CannabisResearch
🫁 New study of 5,211 U.S. young adults: cannabis smoking and dual vaping + smoking were linked to higher odds of new respiratory symptoms; causality cannot be inferred. ➡️ More detail needed on products and use patterns. 🔗 https://f.mtr.cool/ieibvoiumx #CannabisResearch
➡️ Key takeaway: In 164 adults analyzed, 12-week oral cannabinoid capsules were linked to improvements across chronic pain symptoms except cognitive function abilities. 🔗 https://f.mtr.cool/jkfzzusluq #CannabisResearch
➡️ Key takeaway: In 505 medical cannabis patients, adult-use laws were linked to less stress/legal concern, higher perceived quality/availability, higher prices, and reduced stigma. 🔗 https://f.mtr.cool/omxgwlymsb #CannabisResearch
➡️ Key takeaway: In 1,449 sleep-clinic adults, chronic daily cannabis use was linked to more nighttime wakefulness, lower sleep efficiency, and more N1 light sleep. Causality cannot be inferred. 🔗 https://f.mtr.cool/twvpuqcipb #CannabisResearch
🧪 In a Michigan pregnancy cohort, self-reported prenatal cannabis use was 14.2% vs 19.1% by urine toxicology. ➡️ Self-reports may underestimate exposure; biospecimens can improve validity. 🔗 https://f.mtr.cool/xukbzgwkpm #CannabisResearch
📆 Save the Date: Oct 1–2! The 2026 CMCR Symposium: Cannabis & Sport explores the science of performance & recovery. Virtual & Free! 🧠🏃♂️ Register: https://f.mtr.cool/lguyelqznq #CMCRSymposium
New study: cannabis users rated clear, factual impaired-driving messages as more credible than exaggerated, fear-based, stigmatizing, or punitive ones. ➡️ Key takeaway: harm-reduction messaging may support safer driving choices. 🔗 https://f.mtr.cool/eqpvrygdfn #CannabisResearch
🍃 In interviews with 169 adults aged 60+ in Colorado, motivations for edible cannabis included avoiding pharmaceuticals, exhausted options, new/increasing problems, and benefit claims. ➡️ Perceptions varied by THC/CBD profile. 🔗 https://f.mtr.cool/xilevuqhpo #CannabisResearch
📢 New study from Igor Grant & Jamie Corroon: In CA, doctor-recommended cannabis use among past-month users fell from 18.5% in 2019 to 8.5% in 2024, while overall use stayed stable. Suggests adult-use access may reduce medical oversight. https://f.mtr.cool/vzhqkcvxni
📊 U.S. survey data from 2008–2019 found past-30-day cannabis use rose across racial/ethnic groups and SPD status. ➡️ In 2019, use was 27.9% with SPD vs 10.7% without. 🔗 https://f.mtr.cool/mitganpkgy #CannabisResearch