I'm proud that this work is published and thankful for the excellent computational biology program I am a part of @csbpitt.bsky.social and @cmupittcompbio.bsky.social!

@robineclee.bsky.social · 12mo ago

In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF

bioZone isn't just the name of your favorite educational youTube channel, its also an important strategy for geologists watch on YouTube to support us 👇 youtube.com/shorts/lBfg6...

Thrilled to see our latest work online in Nature Communications rdcu.be/ezTxF! Congratulations and thanks to @cmupittcompbio.bsky.social PhD student Steven Smeal and all the co-authors for their critical contributions.

Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics

Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...

rdcu.be

New publication alert! 🧬 A team of Pitt computational biologists and virologists built a detailed model of how Eastern equine encephalitis virus rapidly hijacks host cells to replicate. Check it out in PLOS Computational Biology. 🔗 tinyurl.com/EasternEquine #virology #computationalbiology

A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell

Author summary Eastern equine encephalitis virus (EEEV) is a positive-sense RNA virus transmitted via mosquitoes. It can cause lethal disease in humans with a high mortality rate, exceeding 30%. There...

tinyurl.com

Congrats to all our 2025 CPCB grads! 🎓

Computational & Systems Biology Dept. at Pitt @csbpitt.bsky.social · last yr.

Congratulations to our graduates who attended the School of Medicine Class of 2025 Graduation yesterday! 🎓 💛

Was proud and honored to hood Dr. Drew McNutt at the Pitt School of Medicine Diploma Ceremony. Here we are rocking both the blue and gold and tartan colors representing our joint Pitt-CMU CompBio PhD program. Congratulations to Drew and the other @cmupittcompbio.bsky.social graduates!

When a bovine cytokine talks to a human cell: Lessons from cross-species signaling experiments. 😊 🐱 🐰 🐁 🐀 🐄 www.biorxiv.org/content/10.1...

Happy Pi Day from CPCB! We can't have our pie and eat it too, but we'll always have pi 🟡🥧❤️

Congratulations to Dr. Drew McNutt who last month successfully defended his thesis, Efficiency through Abstraction: Representation Learning for Cost-Effective Drug Discovery! Drew next plans to hike the Appalachian Trail -Can't wait to hear about this next exciting achievement! 🧪🧑‍💻➡️🥾🏕️

Celebrating our Fall 2024 grads as we roll into 2025 🥳 Congrats to all our newest alumni! Can't what to see what you do next 🧪🎓

When Ali Tugrul Balci moved from Istanbul to Pittsburgh, he didn’t expect to find a second home. But through his PhD program, he discovered both a supportive community and a passion for #computationalbiology research. Read more in our graduate spotlight story: tinyurl.com/AliTugrulBalci

What makes a queen bee a queen? 🐝🧬 shout out to @maliqa.bsky.social for narrating her first bioZone video! watch on YouTube to support us 👇 youtube.com/shorts/0X8Iq...

Congratulations to Joint CMU-Pitt PhD Program in Computational Biology student Achyudhan Kutuva, who received an award to attend the 2025 Systems Approaches to Cancer Biology (SACB) Conference in February. Good luck!

Congratulations to PhD candidate Sophia Hu, who recently delivered a talk at the International Conference on Systems Biology in Bombay, India. This was Hu’s first experience at an international conference, but she left feeling excited for the future of the field. 🔗Read more: tinyurl.com/SophiaHu

Last week several of our students presented their research at NeurIPS 2024 in Vancouver. We are so proud of the excellent work that they've accomplished and shared with the scientific community! 🧪 Check out each of their papers below:

Some of our faculty and students met up in Vancouver for @neuripsconf.bsky.social this past week to share and learn the latest in ML research - CPCB student poster pictures coming soon 👀

I'm presenting a new paper "Exploring Discrete Flow Matching for 3D De Novo Molecule Generation" at @workshopmlsb.bsky.social this week! More info in this thread but reach out if want to chat at NeurIPS about generative models or molecular design. arxiv.org/abs/2411.16644

We love to see a student-led collaboration 🧪👩‍💻 Look out for this work at @workshopmlsb.bsky.social!

David Ryan Koes@dkoes.compstruct.org · 2y ago

We're looking forward to presenting this @workshopmlsb.bsky.social . This work was conceived and led by a group CPCB (@cmupittcompbio.bsky.social) students and learns a co-embedding of proteins and ligands to support ultra fast virtual screening. arxiv.org/pdf/2411.15418